Results 1 to 10 of about 10,744,390 (245)

Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1 [PDF]

Nature, 2018
The mammalian cochlea contains two types of mechanosensory hair cell that have different and critical functions in hearing. Inner hair cells (IHCs), which have an elaborate presynaptic apparatus, signal to cochlear neurons and communicate sound information to the brain.
Wiwatpanit, Teerawat, Lorenzen, Sarah M, Cantú, Jorge A, Foo, Chuan Zhi, Hogan, Ann K, Márquez, Freddie, Clancy, John C, Schipma, Matthew J, Cheatham, Mary Ann, Duggan, Anne, García-Añoveros, Jaime   +10 more
openaire   +6 more sources

Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

eLife, 2017
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates.
Stephanie A Bucks, Brandon C Cox, Brittany A Vlosich, James P Manning, Tot B Nguyen, Jennifer S Stone   +5 more
doaj   +2 more sources

Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers

Biology Open, 2018
The utricle of the inner ear, a vestibular sensory structure that mediates perception of linear acceleration, is comprised of two morphologically and physiologically distinct types of mechanosensory hair cells, referred to as Type Is and Type IIs.
Stephen McInturff, Joseph C. Burns, Matthew W. Kelley   +2 more
doaj   +2 more sources

Cell-Specific Transcriptome Analysis Shows That Adult Pillar and Deiters' Cells Express Genes Encoding Machinery for Specializations of Cochlear Hair Cells

Frontiers in Molecular Neuroscience, 2018
The mammalian auditory sensory epithelium, the organ of Corti, is composed of hair cells and supporting cells. Hair cells contain specializations in the apical, basolateral and synaptic membranes.
Huizhan Liu, Lei Chen, Lei Chen, Kimberlee P. Giffen, Sean T. Stringham, Yi Li, Paul D. Judge, Kirk W. Beisel, David Z. Z. He   +8 more
doaj   +2 more sources

Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle [PDF]

Nature Communications
Vestibular hair cells are mechanoreceptors critical for detecting head position and motion. In mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is nearly absent.
Tian Wang, Tian Yang, Amanda Kedaigle, Gabriela Pregernig, Ryan McCarthy, Ben Holmes, Xudong Wu, Lars Becker, Ning Pan, Kathy So, Leon Chen, Jun He, Ahmad Mahmoudi, Soumya Negi, Monika Kowalczyk, Tyler Gibson, Noah Druckenbrod, Alan G. Cheng, Joseph Burns   +18 more
doaj   +2 more sources

Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells

Frontiers in Cellular Neuroscience, 2022
After a damaging insult, hair cells can spontaneously regenerate from cochlear supporting cells within the first week of life. While the regenerated cells express several markers of immature hair cells and have stereocilia bundles, their capacity to ...
Mitchell L. Heuermann, Sophia Matos, Sophia Matos, Deborah Hamilton, Brandon C. Cox, Brandon C. Cox   +5 more
doaj   +1 more source

RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses

Frontiers in Molecular Neuroscience, 2021
The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time.
Stefanie Krinner, Stefanie Krinner, Stefanie Krinner, Friederike Predoehl, Dinah Burfeind, Christian Vogl, Christian Vogl, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +10 more
doaj   +1 more source

Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]

PLoS ONE, 2013
In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati, Isabelle Roux, Elisabeth Glowatzki, Angelika Doetzlhofer   +3 more
doaj   +1 more source

Efferent control of the electrical and mechanical properties of hair cells in the bullfrog's sacculus. [PDF]

PLoS ONE, 2010
Hair cells in the auditory, vestibular, and lateral-line systems respond to mechanical stimulation and transmit information to afferent nerve fibers. The sensitivity of mechanoelectrical transduction is modulated by the efferent pathway, whose activity ...
Manuel Castellano-Muñoz, Samuel H Israel, A J Hudspeth   +2 more
doaj   +1 more source

Hair cell regeneration [PDF]

Current Opinion in Neurobiology, 2008
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell development and have suggested ways that the sensory epithelia could be manipulated to achieve hair cell ...
Zheng-Yi Chen, Zheng-Yi Chen, Albert S.B. Edge   +2 more
openaire   +3 more sources