Results 1 to 10 of about 10,895,649 (358)

Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1 [PDF]

Nature, 2018
The mammalian cochlea contains two types of mechanosensory hair cell that have different and critical functions in hearing. Inner hair cells (IHCs), which have an elaborate presynaptic apparatus, signal to cochlear neurons and communicate sound ...
T. Wiwatpanit, Sarah M. Lorenzen, Jorge A Cantu, Chuan Zhi Foo, Ann K. Hogan, Freddie Márquez, John C. Clancy, M. Schipma, M. Cheatham, A. Duggan, J. García-Añoveros   +10 more
semanticscholar   +6 more sources

Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

eLife, 2017
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates.
Stephanie A Bucks, Brandon C Cox, Brittany A Vlosich, James P Manning, Tot B Nguyen, Jennifer S Stone   +5 more
doaj   +2 more sources

Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers

Biology Open, 2018
The utricle of the inner ear, a vestibular sensory structure that mediates perception of linear acceleration, is comprised of two morphologically and physiologically distinct types of mechanosensory hair cells, referred to as Type Is and Type IIs.
Stephen McInturff, Joseph C. Burns, Matthew W. Kelley   +2 more
doaj   +2 more sources

Cell-Specific Transcriptome Analysis Shows That Adult Pillar and Deiters' Cells Express Genes Encoding Machinery for Specializations of Cochlear Hair Cells

Frontiers in Molecular Neuroscience, 2018
The mammalian auditory sensory epithelium, the organ of Corti, is composed of hair cells and supporting cells. Hair cells contain specializations in the apical, basolateral and synaptic membranes.
Huizhan Liu, Lei Chen, Lei Chen, Kimberlee P. Giffen, Sean T. Stringham, Yi Li, Paul D. Judge, Kirk W. Beisel, David Z. Z. He   +8 more
doaj   +2 more sources

prdm1a drives a fate switch between hair cells of different mechanosensory organs [PDF]

Nature Communications
Vertebrate inner ear mechanosensory hair cells detect sound and gravitational forces. Additionally, fishes have homologous lateral line hair cells in the skin that detect water vibrations for orientation and predator avoidance.
Jeremy E. Sandler, Ya-Yin Tsai, Shiyuan Chen, Logan Sabin, Mark E. Lush, Abhinav Sur, Elizabeth Ellis, Nhung T. T. Tran, Malcolm Cook, Allison R. Scott, Jonathan S. Kniss, Jeffrey A. Farrell, Tatjana Piotrowski   +12 more
doaj   +2 more sources

Functional hair follicle regeneration: an updated review

Signal Transduction and Targeted Therapy, 2021
The hair follicle (HF) is a highly conserved sensory organ associated with the immune response against pathogens, thermoregulation, sebum production, angiogenesis, neurogenesis and wound healing. Although recent advances in lineage-tracing techniques and
Xiaobing Fu
exaly   +2 more sources

Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation.

Frontiers in Aging Neuroscience, 2015
The innervation of the inner ear critically depends on the two neurotrophins Ntf3 and Bdnf. In contrast to this molecularly well established dependency, evidence regarding the need of innervation for long-term maintenance of inner ear hair cells is ...
Jennifer eKersigo, Bernd eFritzsch
doaj   +2 more sources

Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle [PDF]

Nature Communications
Vestibular hair cells are mechanoreceptors critical for detecting head position and motion. In mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is nearly absent.
Tian Wang, Tian Yang, Amanda Kedaigle, Gabriela Pregernig, Ryan McCarthy, Ben Holmes, Xudong Wu, Lars Becker, Ning Pan, Kathy So, Leon Chen, Jun He, Ahmad Mahmoudi, Soumya Negi, Monika Kowalczyk, Tyler Gibson, Noah Druckenbrod, Alan G. Cheng, Joseph Burns   +18 more
doaj   +2 more sources

Pharmacological regeneration of sensory hair cells restores afferent innervation and vestibular function [PDF]

The Journal of Clinical Investigation
The sensory cells that transduce the signals for hearing and balance are highly specialized mechanoreceptors called hair cells that together with supporting cells comprise the sensory epithelia of the inner ear. Loss of hair cells from toxin exposure and
Hanae Lahlou, Hong Zhu, Wu Zhou, Albert S.B. Edge   +3 more
doaj   +2 more sources

Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells

Frontiers in Cellular Neuroscience, 2022
After a damaging insult, hair cells can spontaneously regenerate from cochlear supporting cells within the first week of life. While the regenerated cells express several markers of immature hair cells and have stereocilia bundles, their capacity to ...
Mitchell L. Heuermann, Sophia Matos, Sophia Matos, Deborah Hamilton, Brandon C. Cox, Brandon C. Cox   +5 more
doaj   +1 more source