Results 1 to 10 of about 475,797 (351)

Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice [PDF]

eLife, 2017
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates.
Stephanie A Bucks, Brandon C Cox, Brittany A Vlosich, James P Manning, Tot B Nguyen, Jennifer S Stone   +5 more
doaj   +3 more sources

prdm1a drives a fate switch between hair cells of different mechanosensory organs [PDF]

Nature Communications
Vertebrate inner ear mechanosensory hair cells detect sound and gravitational forces. Additionally, fishes have homologous lateral line hair cells in the skin that detect water vibrations for orientation and predator avoidance.
Jeremy E. Sandler, Ya-Yin Tsai, Shiyuan Chen, Logan Sabin, Mark E. Lush, Abhinav Sur, Elizabeth Ellis, Nhung T. T. Tran, Malcolm Cook, Allison R. Scott, Jonathan S. Kniss, Jeffrey A. Farrell, Tatjana Piotrowski   +12 more
doaj   +2 more sources

Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells [PDF]

Cell Reports, 2017
Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells.
Will J. McLean, Xiaolei Yin, Lin Lu, Danielle R. Lenz, Dalton McLean, Robert Langer, Jeffrey M. Karp, Albert S.B. Edge   +7 more
doaj   +4 more sources

Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells

Frontiers in Cellular Neuroscience, 2022
After a damaging insult, hair cells can spontaneously regenerate from cochlear supporting cells within the first week of life. While the regenerated cells express several markers of immature hair cells and have stereocilia bundles, their capacity to ...
Mitchell L. Heuermann, Sophia Matos, Sophia Matos, Deborah Hamilton, Brandon C. Cox, Brandon C. Cox   +5 more
doaj   +1 more source

Transcriptomic characterization of dying hair cells in the avian cochlea

Cell Reports, 2021
Summary: Sensory hair cells are prone to apoptosis caused by various drugs including aminoglycoside antibiotics. In mammals, this vulnerability results in permanent hearing loss because lost hair cells are not regenerated.
Nesrine Benkafadar, Amanda Janesick, Mirko Scheibinger, Angela H. Ling, Taha A. Jan, Stefan Heller   +5 more
doaj   +1 more source

Apicosome: Newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells

iScience, 2023
Summary: Cochlear and vestibular hair cells are highly specialized sensory receptors for hearing and balance. Here, we report a serendipitous identification of a hair-cell-specific organelle in neonatal mouse inner ear, which we name “apicosome.” The ...
Xiaofen Li, Qirui Zhao, Xiaojie Yu, Wenhan Cao, Yingyi Zhang, Wanying Feng, Liwen Jiang, David Z. He, Robert Z. Qi, Pingbo Huang   +9 more
doaj   +1 more source

Hair cell regeneration [PDF]

Current Opinion in Neurobiology, 2008
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell development and have suggested ways that the sensory epithelia could be manipulated to achieve hair cell ...
Albert Sb, Edge, Zheng-Yi, Chen
openaire   +2 more sources

Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]

PLoS ONE, 2013
In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati, Isabelle Roux, Elisabeth Glowatzki, Angelika Doetzlhofer   +3 more
doaj   +1 more source

Efferent control of the electrical and mechanical properties of hair cells in the bullfrog's sacculus. [PDF]

PLoS ONE, 2010
Hair cells in the auditory, vestibular, and lateral-line systems respond to mechanical stimulation and transmit information to afferent nerve fibers. The sensitivity of mechanoelectrical transduction is modulated by the efferent pathway, whose activity ...
Manuel Castellano-Muñoz, Samuel H Israel, A J Hudspeth   +2 more
doaj   +1 more source

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

eLife, 2022
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves   +15 more
doaj   +1 more source