Results 121 to 130 of about 50,414 (231)

Association of intracellular and synaptic organization in cochlear inner hair cells revealed by 3D electron microscopy

Journal of Cell Science, 2015
The ways in which cell architecture is modelled to meet cell function is a poorly understood facet of cell biology. To address this question, we have studied the cytoarchitecture of a cell with highly specialised organisation, the cochlear inner hair ...
Anwen Bullen, T. West, C. Moores, J. Ashmore, R. Fleck, Kirsty MacLellan-Gibson, A. Forge   +6 more
semanticscholar   +1 more source

An efficient strategy for establishing a model of sensorineural deafness in rats

Neural Regeneration Research, 2015
Ototoxic drugs can be used to produce a loss of cochlear hair cells to create animal models of deafness. However, to the best of our knowledge, there is no report on the establishment of a rat deafness model through the combined application of ...
Long Ma, Hai-jin Yi, Fen-qian Yuan, Wei-wei Guo, Shi-ming Yang   +4 more
doaj   +1 more source

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid [PDF]

, 2016
With their essential role in inner-ear function, stereocilia of sensory hair cells demonstrate the importance of cellular actin protrusions. Actin packing in stereocilia is mediated by crosslinkers of the plastin, fascin, and espin families.
Avenarius, Burkard, Chhabra, Claessens, Cox, Cox, Crawley, DeRosier, DeRosier, DeRosier, DeRosier, Drummond, Dumont, Ebrahim, Egelman, Eng, Erde, Francis, Gallien, Gardel, Gillespie, Grimm-Günter, Grüneberg, Gupton, Gustafsson, Hudspeth, Hwang, Jansen, Jones, Jones, Jones, Krey, Krey, Li, Merritt, Michelot, Mogensen, Perrin, Perrin, Purdy, Revenu, Rzadzinska, Salles, Sekerková, Shepherd, Shevchenko, Shin, Shin, Shin, Taylor, Tilney, Tilney, Tilney, Tilney, Tilney, Vignjevic, Volkmann, Waingeh, Wilmarth, Zheng   +59 more
core   +2 more sources

Cell type-specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis.

PLoS Genetics, 2011
Cellular heterogeneity hinders the extraction of functionally significant results and inference of regulatory networks from wide-scale expression profiles of complex mammalian organs.
Ronna Hertzano, Ran Elkon, Kiyoto Kurima, Annie Morrisson, Siaw-Lin Chan, Michelle Sallin, Andrew Biedlingmaier, Douglas S Darling, Andrew J Griffith, David J Eisenman, Scott E Strome   +10 more
doaj   +1 more source

Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem [PDF]

, 2013
Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity.
Andolfi, G., Avallone, B., Di Bonito, M., Franze, A. M., Mancuso, M., Narita, Y., Puelles, L., Rijli, F. M., Sequino, L., Studer, M.   +9 more
core   +5 more sources

LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice

PLoS ONE, 2015
The LKB1 gene, which encodes a serine/threonine kinase, was discovered to play crucial roles in cell differentiation, proliferation, and the establishment of cell polarity.
Yuqin Men, Aizhen Zhang, Haixiang Li, Tingting Zhang, Yecheng Jin, Huashun Li, Jian Zhang, Jiangang Gao   +7 more
semanticscholar   +1 more source

Functional anatomy of the middle and inner ears of the red fox, in comparison to domestic dogs and cats

, 2020
Anatomical middle and inner ear parameters are often used to predict hearing sensitivities of mammalian species. Given that ear morphology is substantially affected both by phylogeny and body size, it is interesting to consider whether the relatively ...
Burda, H., Malkemper, E., Mason, M.
core   +1 more source

The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns

Neural Plasticity, 2018
Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles ...
Shaofeng Liu, Yunfeng Wang, Yongtian Lu, Wen Li, Wenjing Liu, Jun Ma, Fuqin Sun, Mao Li, Zheng-Yi Chen, Kaiming Su, Wenyan Li   +10 more
doaj   +1 more source

RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones

Frontiers in Cellular Neuroscience, 2017
Ribbon synapses of inner hair cells (IHCs) mediate high rates of synchronous exocytosis to indefatigably track the stimulating sound with sub-millisecond precision.
Stefanie Krinner, Stefanie Krinner, Stefanie Krinner, Tanvi Butola, Tanvi Butola, Tanvi Butola, SangYong Jung, SangYong Jung, SangYong Jung, SangYong Jung, Carolin Wichmann, Carolin Wichmann, Carolin Wichmann, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +17 more
doaj   +1 more source

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells

EMBO Molecular Medicine, 2014
Protocadherin‐15 (Pcdh15) is a component of the tip‐links, the extracellular filaments that gate hair cell mechano‐electrical transduction channels in the inner ear.

semanticscholar   +1 more source