Results 101 to 110 of about 5,371,069 (241)

Age-related changes in olivocochlear efferent innervation in gerbils

Frontiers in Synaptic Neuroscience
IntroductionAge-related hearing difficulties have a complex etiology that includes degenerative processes in the sensory cochlea. The cochlea comprises the start of the afferent, ascending auditory pathway, but also receives efferent feedback innervation
Friederike Steenken, Friederike Steenken, Asli Pektaş, Christine Köppl, Christine Köppl, Christine Köppl   +5 more
doaj   +1 more source

Damage-induced signalling mechanisms in the neonatal rat cochlea. [PDF]

, 2007
Sound overstimulation and exposure to ototoxic drugs damage cochlear hair cells (HCs) and cause their death. The surrounding support cells maintain an epithelial barrier and the appropriate physiological environment for surviving HCs during pathological ...
Lahne, M.
core  

Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]

, 2015
Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Paromita Majumder, Majumder, P, Duchen, MR, Jonathan E. Gale, Michael R. Duchen, Gale, JE   +5 more
core   +1 more source

Tonotopically distinct OFF responses arise in the mouse auditory midbrain following sideband suppression

The Journal of Physiology, EarlyView.
Abstract figure legend Sounds of different frequencies elicit spatially distinct patterns of neural activity within the inferior colliculus aligned to the tonotopic organization of afferent projections. Sound‐evoked neural responses can be visualized in awake mice that express fluorescent Ca2+ sensors.
Patrick D. Parker, Amanda M. Lauer, Dwight E. Bergles   +2 more
wiley   +1 more source

Noise‐induced reduction and early recovery of superior paraolivary nucleus sound‐offset responses

The Journal of Physiology, EarlyView.
Abstract figure legend Acoustic over‐exposure transiently disrupts auditory temporal processing in mouse superior paraolivary nucleus neurons. In control conditions, neurons exhibit robust sound‐offset (OFF) responses, which are abolished immediately following noise trauma, indicating impaired temporal encoding.
Mihai Stancu, Ezhilarasan Rajaram, Joseph A. Kroeger, Benedikt Grothe, Conny Kopp‐Scheinpflug   +4 more
wiley   +1 more source

Defects in hair cells disrupt the development of auditory peripheral circuitry

Nature Communications
Deafness is the most common form of sensory impairment in humans and frequently caused by defects in hair cells of the inner ear. Here we demonstrate that in male mice which model recessive non-syndromic deafness (DFNB6), inactivation of Tmie in hair ...
Riley T. Bottom, Yijun Xu, Caroline Siebald, Jinsei Jung, Ulrich Müller   +4 more
doaj   +1 more source

Investigating the expression profiles of cysteine string proteins (CSPs) in cochlear tissue

Journal of Otology
Objective: This study aims to explore the expression patterns of cysteine string protein alpha (CSPα) and cysteine string protein beta (CSPβ) in the mammalian inner ear, with an emphasis on their temporal dynamics during the developmental stages of C57BL/
Shili Zhang, Caiji Wang, Yuehua Qiao, Xi Shi   +3 more
doaj   +1 more source

Developmental gene expression profile of Vmo1 in the mouse auditory system [PDF]

, 2013
Hearing loss (HL) is a sensory disorder that affects an estimated 250 million people worldwide and can greatly affect quality of life. In New Zealand, more than 10% of the population is affected by HL with the Māori population being overrepresented among
Forrester-Gauntlett, Blaise Kelly Erin
core  

Uncovering the Genetic Landscape of Pediatric Hearing Loss Along the Texas–Mexico Border

Clinical Genetics, Volume 110, Issue 5, Page 627-636, November 2026.
Project GIVE provided evaluations and genome sequencing to 23 children with hearing loss along the Texas–Mexico border. Seventy percent received a molecular diagnosis and 56% of those diagnosed had changes to medical management. In this region, underdiagnosis of genetic hearing loss is due to care barriers rather than lower genetic burden.
Desiree Lanehart, Michelle Gray, Roberta Sierra, Camille Maldonado, Daniel Brooks, Hongzheng Dai, Aaly Rahimtoola, Sandy Magallan, Sarah Rodriguez, Jose Gamez, Pattie Rosenlund, Surya N. Mulukutla, Alberto Allegre, Lori Berry, Brendan Lee, Daryl A. Scott, Blake Vuocolo, Seema R. Lalani   +17 more
wiley   +1 more source

Mechanosensitive Piezo channels and their potential roles in peripheral auditory perception

Brain-X
Hearing sound and responding to external and internal mechanical stimuli requires specific proteins as mechanotransducers that convert mechanical forces into biological signals.
Zhangyi Yi, Ge Yin, Chunjiang Wei, Yizhou Quan, Yu Sun   +4 more
doaj   +1 more source