Results 91 to 100 of about 5,371,069 (241)

Speech Recognition Deficits in Presbyacusis: Links to Cortical Structural and Functional Alterations

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To characterize speech recognition in presbyacusis and its associated neurophysiological and cortical structural features, and to explore structure‐function‐behavior relationships within the presbyacusis phenotype. Methods Thirty elderly patients with presbyacusis(HI) and thirty‐three healthy young controls(NH) completed a behavioral
Xiao‐Qian Ren, Lan Lan, Xiao‐Long Li, Xiang‐Bing Bian, Jin Li, Lan Yu, Dan‐Yang Li, Xin Lou, Qiu‐Ju Wang   +8 more
wiley   +1 more source

Viral-mediated Ntf3 overexpression disrupts innervation and hearing in nondeafened guinea pig cochleae

Molecular Therapy: Methods & Clinical Development, 2016
Synaptopathy in the cochlea occurs when the connection between inner hair cells and the auditory nerve is disrupted, leading to impaired hearing and nerve degeneration. Experiments using transgenic mice have shown that overexpression of NT3 by supporting
Min Young Lee, Takaomi Kurioka, Megan M Nelson, Diane M Prieskorn, Donald L Swiderski, Yohei Takada, Lisa A Beyer, Yehoash Raphael   +7 more
doaj   +1 more source

Conditional Tnfaip6-Knockout in Inner Ear Hair Cells Does not Alter Auditory Function

Neuroscience Bulletin
Noise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity. This condition is closely linked to inflammatory responses, and interventions targeting the inflammatory gene tumor necrosis factor-alpha (TNFα) are known to mitigate cochlear noise damage. TNFα-induced proteins (
Qiu, Yue, Gao, Song, Ding, Xiaoqiong, Lu, Jie, Ji, Xinya, Hao, Wenli, Cheng, Siqi, Du, Haolinag, Gu, Yajun, Yu, Chenjie, Cheng, Cheng, Gao, Xia   +11 more
openaire   +2 more sources

Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]

, 2013
Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core  

Decoding Dual Regulatory Layers: Integrating Differential Expression and Alternative Splicing Dynamics in the Evolution of Laryngeal Echolocation Across Chiropteran Lineages

Integrative Zoology, EarlyView.
We integrated short‐read and long‐read RNA‐seq data from cochlear tissues of echolocating and non‐echolocating bats to disentangle transcriptional and post‐transcriptional regulation. Echolocating bats showed neural‐function enrichment among differentially expressed genes, while alternatively spliced genes were linked to epigenetic regulation. Overlaps
Jianyu Wu, Daoyuan Hu, Min Chen, Xiuguang Mao   +3 more
wiley   +1 more source

Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss

Integrative Zoology, EarlyView.
The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng, Lu Wang, Runhan Li, Wenkai Lai, Chongkui Sun, Jianguo Cui, Bicheng Zhu, Jiang Zhang   +7 more
wiley   +1 more source

Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice

Neural Plasticity, 2018
The auditory function develops and matures after birth in many mammalian species. After hearing onset, environmental sounds exert profound and long-term effects on auditory functions.
Aoshuang Chang, Peng Chen, Shasha Guo, Nana Xu, Wenlu Pan, Hongzheng Zhang, Cuixian Li, Jie Tang   +7 more
doaj   +1 more source

Transplantation and survival of mouse inner ear progenitor/stem cells in the organ of Corti after cochleostomy of hearing-impaired guinea pigs: preliminary results

Brazilian Journal of Medical and Biological Research, 2016
In mammals, damage to sensory receptor cells (hair cells) of the inner ear results in permanent sensorineural hearing loss. Here, we investigated whether postnatal mouse inner ear progenitor/stem cells (mIESCs) are viable after transplantation into the ...
L.C.M. Barboza Jr., K. Lezirovitz, D.B. Zanatta, B.E. Strauss, R.C. Mingroni-Netto, J. Oiticica, L.A. Haddad, R.F. Bento   +7 more
doaj   +1 more source

Phylogenetic and ecological duality in the otoliths of Sciaenidae

Cladistics, EarlyView.
Abstract Teleost fishes have evolved taxon‐specific otoliths that vary greatly in size and shape and are primarily involved in hearing and balance. This study identifies the main drivers of otolith shape disparity in Sciaenidae, a clade of sound‐producing bony fishes, using three‐dimensional geometric morphometrics (3DGM).
Dominique Mediodia, Roland B. Sookias, Valentin Fischer, Chien‐Hsiang Lin   +3 more
wiley   +1 more source

Early Outer Hair Cell Dysfunction Associated With Educational Noise Exposure in Dental Students: Implications for Hearing Conservation in Dental Education

European Journal of Dental Education, EarlyView.
ABSTRACT Introduction Dental education involves continuous exposure to high‐frequency noise from clinical instruments, which may cause early outer hair cell damage even before professional practice begins. While noise‐induced hearing loss (NIHL) is a recognised occupational hazard among dentists, evidence regarding subclinical outer hair cell changes ...
Merve Yelken Kendirci, Mehtap Ungor, Handan Turan Dizdar, Ahmet Faruk Erturk, Ilknur Ozcan   +4 more
wiley   +1 more source