Eye &ENT Research, EarlyView.ABSTRACT Background Hearing loss affects 1.5 billion people globally, with sensorineural hearing loss (SNHL) linked to hypertension. Hypertension affects 1.39 billion people worldwide and its prevalence is rising sharply in Sub‐Saharan Africa. While 12% of Tanzanian population has cardiovascular diseases, including hypertension and recent studies ...
Johnson Shayo +3 more
wiley +1 more source
Short-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells [PDF]
, 2011 In the mammalian inner ear, the gain control of auditory inputs is exerted by medial olivocochlear (MOC) neurons that innervate cochlear outer hair cells (OHCs).
Ballestero, Jimena Andrea +5 more
core +1 more source
Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment
Exploration, EarlyView.This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng +11 more
wiley +1 more source
Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
Scientific Reports, 2017 The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback.
Nikola Ciganović +2 more
doaj +1 more source
Expression and Localization of CaBP Ca2+ Binding Proteins in the Mouse Cochlea. [PDF]
PLoS ONE, 2016 CaBPs are a family of EF-hand Ca2+ binding proteins that are structurally similar to calmodulin. CaBPs can interact with, and yet differentially modulate, effectors that are regulated by calmodulin, such as Cav1 voltage-gated Ca2+ channels ...
Tian Yang +5 more
doaj +1 more source
The coupling between Ca2+ channels and the exocytotic Ca2+ sensor at hair cell ribbon synapses varies tonotopically along the mature cochlea. [PDF]
, 2017 The cochlea processes auditory signals over a wide range of frequencies and intensities. However, the transfer characteristics at hair cell ribbon synapses are still poorly understood at different frequency locations along the cochlea.
Cho, S. +4 more
core +1 more source
Advanced flexible brain computer interface materials: From development to application
FlexMat, EarlyView.This review explores how novel materials coatings are advancing brain‐computer interface (BCI) technology. It describes how these materials help overcome key challenges in signal accuracy, biocompatibility, and device durability. The paper highlights BCI applications in medicine and entertainment, and discusses future trends that could transform human ...
Renquan Guan +5 more
wiley +1 more source
Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing
Cell Reports, 2019 Summary: Single-cell RNA sequencing is a powerful tool by which to characterize the transcriptional profile of low-abundance cell types, but its application to the inner ear has been hampered by the bony labyrinth, tissue sparsity, and difficulty ...
Paul T. Ranum +7 more
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Tsukushi is essential for the development of the inner ear
Molecular Brain, 2020 Tsukushi (TSK)—a small, secreted, leucine-rich-repeat proteoglycan—interacts with and regulates essential cellular signaling cascades. However, its functions in the mouse inner ear are unknown.
Toru Miwa +8 more
doaj +1 more source
Labyrinthine Abnormalities on MRI in Untreated Otosclerosis: Prevalence and Clinical Relevance
The Laryngoscope, EarlyView.In untreated otosclerosis with labyrinthine symptoms, delayed 3D FLAIR MRI rarely demonstrates endolymphatic hydrops but frequently reveals blood–labyrinth barrier (BLB) disruption. BLB enhancement is spatially associated with cochlear endosteal and round window involvement and increases with the severity of the hearing loss phenotype.
Héléna Pencroffi +7 more
wiley +1 more source