Results 81 to 90 of about 16,285 (195)

Defects in hair cells disrupt the development of auditory peripheral circuitry

Nature Communications
Deafness is the most common form of sensory impairment in humans and frequently caused by defects in hair cells of the inner ear. Here we demonstrate that in male mice which model recessive non-syndromic deafness (DFNB6), inactivation of Tmie in hair ...
Riley T. Bottom, Yijun Xu, Caroline Siebald, Jinsei Jung, Ulrich Müller   +4 more
doaj   +1 more source

Investigating the expression profiles of cysteine string proteins (CSPs) in cochlear tissue

Journal of Otology
Objective: This study aims to explore the expression patterns of cysteine string protein alpha (CSPα) and cysteine string protein beta (CSPβ) in the mammalian inner ear, with an emphasis on their temporal dynamics during the developmental stages of C57BL/
Shili Zhang, Caiji Wang, Yuehua Qiao, Xi Shi   +3 more
doaj   +1 more source

Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss

Integrative Zoology, EarlyView.
The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng, Lu Wang, Runhan Li, Wenkai Lai, Chongkui Sun, Jianguo Cui, Bicheng Zhu, Jiang Zhang   +7 more
wiley   +1 more source

Mechanosensitive Piezo channels and their potential roles in peripheral auditory perception

Brain-X
Hearing sound and responding to external and internal mechanical stimuli requires specific proteins as mechanotransducers that convert mechanical forces into biological signals.
Zhangyi Yi, Ge Yin, Chunjiang Wei, Yizhou Quan, Yu Sun   +4 more
doaj   +1 more source

Phylogenetic and ecological duality in the otoliths of Sciaenidae

Cladistics, EarlyView.
Abstract Teleost fishes have evolved taxon‐specific otoliths that vary greatly in size and shape and are primarily involved in hearing and balance. This study identifies the main drivers of otolith shape disparity in Sciaenidae, a clade of sound‐producing bony fishes, using three‐dimensional geometric morphometrics (3DGM).
Dominique Mediodia, Roland B. Sookias, Valentin Fischer, Chien‐Hsiang Lin   +3 more
wiley   +1 more source

Tonotopically distinct OFF responses arise in the mouse auditory midbrain following sideband suppression

The Journal of Physiology, EarlyView.
Abstract figure legend Sounds of different frequencies elicit spatially distinct patterns of neural activity within the inferior colliculus aligned to the tonotopic organization of afferent projections. Sound‐evoked neural responses can be visualized in awake mice that express fluorescent Ca2+ sensors.
Patrick D. Parker, Amanda M. Lauer, Dwight E. Bergles   +2 more
wiley   +1 more source

Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses

Cell Reports, 2018
Summary: A Ca2+ current transient block (ICaTB) by protons occurs at some ribbon-type synapses after exocytosis, but this has not been observed at mammalian hair cells.
Philippe F.Y. Vincent, Soyoun Cho, Margot Tertrais, Yohan Bouleau, Henrique von Gersdorff, Didier Dulon   +5 more
doaj   +1 more source

Noise‐induced reduction and early recovery of superior paraolivary nucleus sound‐offset responses

The Journal of Physiology, EarlyView.
Abstract figure legend Acoustic over‐exposure transiently disrupts auditory temporal processing in mouse superior paraolivary nucleus neurons. In control conditions, neurons exhibit robust sound‐offset (OFF) responses, which are abolished immediately following noise trauma, indicating impaired temporal encoding.
Mihai Stancu, Ezhilarasan Rajaram, Joseph A. Kroeger, Benedikt Grothe, Conny Kopp‐Scheinpflug   +4 more
wiley   +1 more source

Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure

Scientific Reports, 2017
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL.
Felicia Gilels, Stephen T. Paquette, Holly J. Beaulac, Anwen Bullen, Patricia M. White   +4 more
doaj   +1 more source

The tympanic covering layer contributes to basilar membrane elasticity potentially influencing human frequency resolution and speech perception

Journal of Anatomy, Volume 249, Issue 3, Page 528-543, September 2026.
In this study we show for the first time that the human basilar membrane contains elastin produced by the so‐called tympanic covering layer. It is believed to play an important functional role in human cochlear tuning, particularly low frequencies linked to our remarkable speech and music perception.
Wei Liu, Claudia Steinacher, Alexander Glueckert, Rudolf Glueckert, Hao Li, Karin Staxäng, Anneliese Schrott‐Fischer, Hanif M. Ladak, Sumit Agrawal, Helge Rask‐Andersen   +9 more
wiley   +1 more source