Results 81 to 90 of about 5,371,069 (241)

A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

eLife, 2015
We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying intracellular hydrostatic pressure. Furthermore, this F-actin mesh network
Vincent, Philippe F. Y., Bouleau, Yohan, Petit, Christine, Dulon, Didier   +3 more
openaire   +4 more sources

Temporal modulation transfer functions in the European Starling (Sturnus vulgaris): II. Responses of auditory-nerve fibres [PDF]

, 1995
The temporal resolution of cochlear-nerve fibres in the European starling was determined with sinusoidally amplitude-modulated noise stimuli similar to those previously used in a psychoacoustic study in this species (Klump and Okanoya, 1991).
Klump, Georg M., Gleich, Otto, O. Gleich, G.M. Klump   +3 more
core   +1 more source

Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley   +1 more source

Microgravity affects the hair cell ionic currents of the frog semicircular canals [PDF]

, 2010
The effects of microgravity on the biophysical properties of frog labyrinthine hair cells have been examined by analyzing calcium and potassium currents in dissociated cells, using the patch-clamp technique.
Leparulo, Alessandro
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The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells [PDF]

, 2014
International audienceProtocadherin-15 (Pcdh15) is a component of the tip-links, the extracellular filaments that gate hair cell mechano-electrical transduction channels in the inner ear.
Bahloul, Amel, Makrelouf, Mohamed, Richard Goodyear, Muriel Holder, Petit, Christine, Michel, Vincent, Jean‐Pierre Hardelin, Hardelin, Jean-Pierre, Amel Bahloul, Guy Richardson, Pepermans, Elise, Holder, Muriel, Typhaine Dupont, Dupont, Typhaine, Elise Pepermans, Samia Abdi, Mohamed Makrelouf, Zenati, Akila, Marlin, Sandrine, Akila Zenati, Paul Avan, Gherbi, Souad, Vittot, Michel, Richardson, Guy, Sandrine Marlin, Abdi, Samia, Avan, Paul, Goodyear, Richard, Bonnet, Crystel, Souad Gherbi, Vincent Michel, Christine Petit, Crystel Bonnet   +32 more
core   +1 more source

Influence of Vitamin B12 Deficiency on Auditory and Vestibular Functioning: An Objective Test‐Based Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the effectiveness of objective audiological and vestibular assessments in detecting functional changes associated with vitamin B12 deficiency. Data Sources A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and EMBASE databases.
Nesmah Zainab, Santhosh Periyasamy, Kishan Madikeri Mohan   +2 more
wiley   +1 more source

Tsukushi is essential for the development of the inner ear

Molecular Brain, 2020
Tsukushi (TSK)—a small, secreted, leucine-rich-repeat proteoglycan—interacts with and regulates essential cellular signaling cascades. However, its functions in the mouse inner ear are unknown.
Toru Miwa, Kunimasa Ohta, Naofumi Ito, Satoko Hattori, Tsuyoshi Miyakawa, Toru Takeo, Naomi Nakagata, Wen-Jie Song, Ryosei Minoda   +8 more
doaj   +1 more source

A Simple Rheology‐Based Framework for Selecting Printing Parameters in Extrusion‐Based Hydrogel Additive Manufacturing

Polymer Engineering &Science, EarlyView.
An open analytical framework converts standard rheological measurements directly into the complete extrusion field and slicer‐ready printing parameters for Piston driven printers, enabling rapid operational window of printability in direct ink writing without CFD or machine learning. ABSTRACT Predicting whether a gel formulation will print successfully
Thiago M. C. Rodrigues, João V. R. C. dos Santos, Nicole P. Martins, Rossana Mara da Silva Moreira Thiré   +3 more
wiley   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]

, 2006
Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Jagger, DJ, Forge, A
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