Results 61 to 70 of about 16,285 (195)

Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing

Cell Reports, 2019
Summary: Single-cell RNA sequencing is a powerful tool by which to characterize the transcriptional profile of low-abundance cell types, but its application to the inner ear has been hampered by the bony labyrinth, tissue sparsity, and difficulty ...
Paul T. Ranum, Alexander T. Goodwin, Hidekane Yoshimura, Diana L. Kolbe, William D. Walls, Jin-Young Koh, David Z.Z. He, Richard J.H. Smith   +7 more
doaj   +1 more source

Expression and Localization of CaBP Ca2+ Binding Proteins in the Mouse Cochlea. [PDF]

PLoS ONE, 2016
CaBPs are a family of EF-hand Ca2+ binding proteins that are structurally similar to calmodulin. CaBPs can interact with, and yet differentially modulate, effectors that are regulated by calmodulin, such as Cav1 voltage-gated Ca2+ channels ...
Tian Yang, Elizabeth S Scholl, Ning Pan, Bernd Fritzsch, Françoise Haeseleer, Amy Lee   +5 more
doaj   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Neuromorphic Hardware Materials for Intelligent Artificial Perception and Multimodal Fusion: From Sensing to Cognition

Interdisciplinary Materials, EarlyView.
Neuromorphic hardware enables the integration of sensing, memory, and computing for intelligent artificial perception. Recent advances in multimodal fusion further highlight its potential for embodied intelligence and next‐generation human–machine interfaces.
Yixin Zhu, Yuqing Hu, Changjin Wan, Qing Wan   +3 more
wiley   +1 more source

Tsukushi is essential for the development of the inner ear

Molecular Brain, 2020
Tsukushi (TSK)—a small, secreted, leucine-rich-repeat proteoglycan—interacts with and regulates essential cellular signaling cascades. However, its functions in the mouse inner ear are unknown.
Toru Miwa, Kunimasa Ohta, Naofumi Ito, Satoko Hattori, Tsuyoshi Miyakawa, Toru Takeo, Naomi Nakagata, Wen-Jie Song, Ryosei Minoda   +8 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

eLife, 2015
We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying intracellular hydrostatic pressure. Furthermore, this F-actin mesh network
Vincent, Philippe F. Y., Bouleau, Yohan, Petit, Christine, Dulon, Didier   +3 more
openaire   +4 more sources

Predicting cochlear structural alterations from auditory function in age‐related hearing loss mice based on optical coherence tomography

Journal of Intelligent Medicine, EarlyView.
Abstract With global population aging, age‐related hearing loss has become a major public health concern. Understanding the relationship between auditory functional decline and cochlear structural degeneration is essential for early detection and precise intervention.
Shu Zheng, Zhiqi Li, Junyue Wang, Guangjian Ni   +3 more
wiley   +1 more source

Radiotherapy‐Induced Otitis Media With Effusion in Nasopharyngeal Carcinoma: A Meta‐Analysis

The Laryngoscope, EarlyView.
This meta‐analysis of eight studies comprising 582 NPC patients provides the first quantitative synthesis of radiotherapy‐induced otitis media with effusion (OME), demonstrating a significant overall risk difference of 0.18 (95% CI: −0.06 to 0.42, p < 0.0001) in OME naive ears.
Nevin Yi Meng Chua, Yong Hoe Chan, Woei Shyang Loh, De Yun Wang   +3 more
wiley   +1 more source

Viral-mediated Ntf3 overexpression disrupts innervation and hearing in nondeafened guinea pig cochleae

Molecular Therapy: Methods & Clinical Development, 2016
Synaptopathy in the cochlea occurs when the connection between inner hair cells and the auditory nerve is disrupted, leading to impaired hearing and nerve degeneration. Experiments using transgenic mice have shown that overexpression of NT3 by supporting
Min Young Lee, Takaomi Kurioka, Megan M Nelson, Diane M Prieskorn, Donald L Swiderski, Yohei Takada, Lisa A Beyer, Yehoash Raphael   +7 more
doaj   +1 more source