Results 51 to 60 of about 38,105 (239)
A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs
Frontiers in Neuroscience, 2021 Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini +2 more
doaj +1 more source
Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem [PDF]
, 2013 Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity.
Andolfi, G. +9 more
core +5 more sources
Behavioral auditory thresholds and loss of ribbon synapses at inner hair cells in aged gerbils
Experimental Gerontology, 2016 The potential contribution of auditory synaptopathy to age dependent hearing loss was studied in groups of young and old gerbils. The analysis of the number of inner hair cell ribbon synapses in aged gerbils (37.9±3.3months of age) revealed only a relatively small (11-17%) loss in the basal two thirds of the cochlea, while a more pronounced reduction ...
Otto, Gleich +2 more
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2018 During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents ...
Anne-Gabrielle Harrus +5 more
doaj +1 more source
Evaluation of inner hair cell and nerve fiber loss as sufficient pathologies underlying auditory neuropathy [PDF]
Hearing Research, 2009 Auditory neuropathy is a hearing disorder characterized by normal function of outer hair cells, evidenced by intact cochlear microphonic (CM) potentials and otoacoustic emissions (OAEs), with absent or severely dys-synchronized auditory brainstem responses (ABRs).
Mohamed M, El-Badry, Sandra L, McFadden
openaire +2 more sources
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Nature Communications, 2018 Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell ...
Laura F. Corns +12 more
doaj +1 more source
Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear [PDF]
, 2018 It has recently been shown that the oxygen-regulated factors erythropoietin (Epo) and vascular endothelial growth factor (VEGF) confer protection on different cells, including neuronal-derived ones.
Bodmer, Daniel +2 more
core
A novel ENU-induced mutation in Myo6 causes vestibular dysfunction and deafness [PDF]
, 2016 Mouse N-ethyl-N-nitrosourea (ENU) mutagenesis has generated many useful animal models for human diseases. Here we describe the identification of a novel ENU-induced mouse mutant strain Turner (Tur) that displays circling and headtossing behavior and ...
Brahmachary, M +3 more
core +1 more source
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, EarlyView.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source