Results 41 to 50 of about 5,371,069 (241)

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses

eLife, 2021
Acoustic overexposure and aging can damage auditory synapses in the inner ear by a process known as synaptopathy. These insults may also damage hair bundles and the sensory transduction apparatus in auditory hair cells.
John Lee, Kosuke Kawai, Jeffrey R Holt, Gwenaëlle SG Géléoc   +3 more
doaj   +1 more source

The phase response of primary auditory afferents in a songbird (Sturnus vulgaris L.) [PDF]

, 1988
The effects of stimulus frequency and intensity on phase-locking characteristics of cochlear ganglion cells were studied in the starling. All cells showed phase-locking to tone stimuli within their response area. Phase-locking at CF is found on average 9
Gleich, Otto, Narins, P. M.
core   +1 more source

Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration

Journal of Otolaryngology - Head and Neck Surgery, 2013
Objective To investigate glucocorticoid uptake in auditory hair cells following transtympanic versus systemic administration of dexamethasone. Study design Controlled experimental study. Setting Translational science experimental laboratory.
Amandeep S Grewal, Julian M Nedzelski, Joseph M Chen, Vincent YW Lin   +3 more
doaj   +1 more source

Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear Synaptopathy and Hearing Loss

Cells, 2022
Peroxisome Biogenesis Disorders (PBD) and Zellweger syndrome spectrum disorders (ZSD) are rare genetic multisystem disorders that include hearing impairment and are associated with defects in peroxisome assembly, function, or both.
Stephanie A. Mauriac, Thibault Peineau, Aamir Zuberi, Cathleen Lutz, Gwénaëlle S. G. Géléoc   +4 more
doaj   +1 more source

Energy integration describes sound-intensity coding in an insect auditory system [PDF]

, 2002
We investigate the transduction of sound stimuli into neural responses and focus on locust auditory receptor cells. As in other mechanosensory model systems, these neurons integrate acoustic inputs over a fairly broad frequency range.
Andreas V. M. Herz, Gollisch, Tim, Schütze, Hartmut, Benda, Jan, Jan Benda, Herz, Andreas V. M., Hartmut Schütze, Tim Gollisch   +7 more
core   +1 more source

Zinc-finger protein A20 protects hair cells from damage made by high-power microwave

Journal of Bio-X Research, 2019
. Inner ear hair cells are important for maintaining hearing. Irreversible damage to hair cells is an important cause of sensorineural deafness. Electromagnetic radiation, especially high-power microwave, is an important threat to human health in modern ...
Feng Tang, Xiaoling Chen, Lifeng Jia, Hai Li, Jingya Li, Wei Yuan   +5 more
doaj   +1 more source

Age-related changes in auditory nerve–inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice [PDF]

Neuroscience, 2015
This study compared the timing of appearance of three components of age-related hearing loss that determine the pattern and severity of presbycusis: the functional and structural pathologies of sensory cells and neurons and changes in gap detection (GD), the latter as an indicator of auditory temporal processing.
R A, Altschuler, D F, Dolan, K, Halsey, A, Kanicki, N, Deng, C, Martin, J, Eberle, D C, Kohrman, R A, Miller, J, Schacht   +9 more
openaire   +2 more sources

Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses

Frontiers in Cell and Developmental Biology, 2020
Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK) complexes. The protein is expressed in the cell junctions between epithelial cells, which play a role in
Prathamesh T. Nadar-Ponniah, Prathamesh T. Nadar-Ponniah, Shahar Taiber, Michal Caspi, Tal Koffler-Brill, Amiel A. Dror, Amiel A. Dror, Ronen Siman-Tov, Moran Rubinstein, Moran Rubinstein, Krishnanand Padmanabhan, Chen Luxenburg, Richard A. Lang, Karen B. Avraham, Rina Rosin-Arbesfeld   +14 more
doaj   +1 more source

Differences in auditory nerve fiber responses in regard to inner and outer hair cells [PDF]

The Journal of the Acoustical Society of America, 1978
Single unit recordings were made from auditory nerve fibers in the monkey to pure tone stimuli. Extensive studies of frequency response areas suggested the existence of two types of auditory nerve fibers. One type showed a flat-bottomed response area and the other showed a conventional sharp one.
M. Nomoto, M. Maekawa
openaire   +1 more source

The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish

Frontiers in Molecular Neuroscience, 2020
Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by converting mechanical stimuli into electrical signals. This process of mechano-electrical transduction (MET) requires a mechanically gated channel localized in the apical
Timothy Erickson, Timothy Erickson, Itallia V. Pacentine, Alexandra Venuto, Rachel Clemens, Teresa Nicolson   +5 more
doaj   +1 more source