Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells
Frontiers in Neuroscience, 2021 Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca +10 more
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Molecular biology of hearing [PDF]
, 2012 The inner ear is our most sensitive sensory organ and can be subdivided into three functional units: organ of Corti, stria vascularis and spiral ganglion.
Diensthuber, M +3 more
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Development of otic organoids and their current status [PDF]
Organoid, 2023 The inner ear is responsible for both hearing and balance in the body, and since the initial development of otic (inner ear) organoids from mouse pluripotent stem cells (PSCs) in 2013, significant advances have been made in this field. Bone morphogenetic
Hantai Kim +9 more
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eLife, 2019 The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the
Meenakshi Prajapati-DiNubila +4 more
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A Biophysical Model of the Inner Hair Cell: The Contribution of Potassium Currents to Peripheral Auditory Compression [PDF]
Journal of the Association for Research in Otolaryngology, 2006 The term peripheral auditory compression refers to the fact that the whole range of audible sound pressure levels is mapped into a narrower range of auditory nerve responses. Peripheral compression is the by-product of independent compressive processes occurring at the level of the basilar membrane, the inner hair cell (IHC), and the auditory nerve ...
Enrique A, Lopez-Poveda +1 more
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Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. [PDF]
, 2015 Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
Daniel J. Jagger +38 more
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Characterization of the Usher Syndrome gene CDH23: implications for mechanosensation in the vertebrate inner ear [PDF]
, 2004 Deafness is the most common form of sensory impairment afflicting the human population. Approximately one in eight hundred children is born with serious hearing impairment and more than half of these cases are likely due to single gene defects.
Siemens, Jan-Erik
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Inner-Hair Cells Parameterized-Hardware Implementation for Personalized Auditory Nerve Stimulation [PDF]
, 2011 In this paper the hardware implementation of an inner hair cell model is presented. Main features of the design are the use of Meddis’ transduction structure and the methodology for Design with Reusability. Which allows future migration to new hardware and design refinements for speech processing and custom-made hearing ...
Miguel A. Sacristán-Martínez +4 more
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The organization of tip links and stereocilia on hair cells of bird and lizard basilar papillae [PDF]
, 1989 Auditory papillae from three species of bird (pigeon, starling, and chick), and two species of European lizard (Podarcis murolis and Podarcis sic&) were examined by scanning electron microscopy.
Pickles, J. O. +7 more
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Static length changes of cochlear outer hair cells can tune low-frequency hearing.
PLoS Computational Biology, 2018 The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović +5 more
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