Results 21 to 30 of about 16,285 (195)
eLife, 2019 The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the
Meenakshi Prajapati-DiNubila +4 more
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Inner-Hair Cells Parameterized-Hardware Implementation for Personalized Auditory Nerve Stimulation [PDF]
, 2011 In this paper the hardware implementation of an inner hair cell model is presented. Main features of the design are the use of Meddis’ transduction structure and the methodology for Design with Reusability. Which allows future migration to new hardware and design refinements for speech processing and custom-made hearing ...
Miguel A. Sacristán-Martínez +4 more
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Static length changes of cochlear outer hair cells can tune low-frequency hearing.
PLoS Computational Biology, 2018 The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović +5 more
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Perspectives on Auditory Neuropathy: Disorders of Inner Hair Cell, Auditory Nerve, and Their Synapse [PDF]
, 2008 The term auditory neuropathy (Starr, A. et al., 1996) was first used to describe a hearing disorder due to altered function of the auditory nerve in the presence of preserved functions of cochlear outer hair cells (OHCs; Starr, A. et al., 1991). The hearing loss has specific features reflecting impairment of auditory temporal processes that are ...
Starr, Arnold +5 more
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Remodeling of the Inner Hair Cell Microtubule Meshwork in a Mouse Model of Auditory Neuropathy AUNA1 [PDF]
eneuro, 2016 AbstractAuditory neuropathy 1 (AUNA1) is a form of human deafness resulting from a point mutation in the 5′ untranslated region of theDiaphanous homolog 3(DIAPH3) gene. Notably, theDIAPH3mutation leads to the overexpression of the DIAPH3 protein, a formin family member involved in cytoskeleton dynamics. Through study of diap3-overexpressing transgenic (
Surel, Clément +9 more
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Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear.
PLoS ONE, 2012 During embryonic development, hair cells and support cells in the sensory epithelia of the inner ear derive from progenitors that express Sox2, a member of the SoxB1 family of transcription factors.
Stephen D Freeman, Nicolas Daudet
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C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.
PLoS ONE, 2021 Hearing depends on the transduction of sounds into neural signals by the inner hair cells of the cochlea. Cochleae also have outer hair cells with unique electromotile properties that increase auditory sensitivity, but they are particularly susceptible ...
Joyshree Biswas +8 more
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Rat Auditory Inner Hair Cell Mechanotransduction and Stereociliary Membrane Diffusivity Are Similarly Modulated by Calcium [PDF]
iScience, 2020 The lipid bilayer plays a pivotal role in force transmission to many mechanically-gated channels. We developed the technology to monitor membrane diffusivity in order to test the hypothesis positing that Ca2+ regulates open probability (P o) of cochlear hair cell mechanotransduction (MET) channels via the plasma membrane. The stereociliary membrane was
Shefin S. George +2 more
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eLife, 2021 Acoustic overexposure and aging can damage auditory synapses in the inner ear by a process known as synaptopathy. These insults may also damage hair bundles and the sensory transduction apparatus in auditory hair cells.
John Lee +3 more
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Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration
Journal of Otolaryngology - Head and Neck Surgery, 2013 Objective To investigate glucocorticoid uptake in auditory hair cells following transtympanic versus systemic administration of dexamethasone. Study design Controlled experimental study. Setting Translational science experimental laboratory.
Amandeep S Grewal +3 more
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