Results 11 to 20 of about 38,105 (239)
Cell Death and Disease, 2022 The mammalian cochlea is an exceptionally well-organized epithelium composed of hair cells, supporting cells, and innervating neurons. Loss or defects in any of these cell types, particularly the specialized sensory hair cells, leads to deafness.
Felicia A. Gilels +4 more
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Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model
Frontiers in Cellular Neuroscience, 2022 Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine.
Xin Deng, Zhengqing Hu, Zhengqing Hu
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Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells [PDF]
, 2014 Mechanotransduction in the auditory and vestibular systems depends on mechanosensitive ion channels in the stereociliary bundles that project from the apical surface of the sensory hair cells.
Corns, Laura F +3 more
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Sensory Transduction and Adaptation in Inner and Outer Hair Cells of the Mouse Auditory System [PDF]
Journal of Neurophysiology, 2007 Auditory function in the mammalian inner ear is optimized by collaboration of two classes of sensory cells known as inner and outer hair cells. Outer hair cells amplify and tune sound stimuli that are transduced and transmitted by inner hair cells. Although they subserve distinct functions, they share a number of common properties. Here we compare the
Eric A, Stauffer, Jeffrey R, Holt
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Research Progress on the Mechanism of Cochlear Hair Cell Regeneration
Frontiers in Cellular Neuroscience, 2021 Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
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Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear [PDF]
Cellular and Molecular Life Sciences, 2009 It has recently been shown that the oxygenregulated factors erythropoietin (Epo) and vascular endothelial growth factor (VEGF) confer protection on different cells, including neuronal-derived ones. The receptors for Epo and VEGF are widely expressed in different organs. Since mammalian auditory hair cells can irreversibly be damaged by different agents,
Monge Naldi, Arianne +2 more
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Kölliker’s organ-supporting cells and cochlear auditory development
Frontiers in Molecular Neuroscience, 2022 The Kölliker’s organ is a transient cellular cluster structure in the development of the mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal cells in the internal sulcus at postnatal day 12 (P12)–P14, with the cochlea ...
Jianyong Chen +11 more
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Parallel Distribution of an Inner Hair Cell and Auditory Nerve Model for Real-Time Application [PDF]
IEEE Transactions on Biomedical Circuits and Systems, 2017 This paper summarizes recent efforts in implementing a model of the ear's inner hair cell and auditory nerve on a neuromorphic hardware platform, the SpiNNaker machine. This exploits the massive parallelism of the target architecture to obtain real-time modeling of a biologically realistic number of human auditory nerve fibres.
Robert James +6 more
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Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells
Frontiers in Neuroscience, 2021 Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca +10 more
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Approaches of auditory hair cells induction from stem cells
Otorhinolaryngology and Facial Plastic Surgery, 2017 Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Shahrokh Khoshsirat +2 more
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