Results 161 to 170 of about 37,698 (205)

Decision letter: A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

, 2015
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Inner hair cell synapse density influences auditory processing

2022
AbstractLoss of synapses between spiral ganglion neurons and inner hair cells (IHC synaptopathy), leads to an auditory neuropathy called hidden hearing loss (HHL) characterized by normal auditory thresholds but reduced amplitude of sound-evoked auditory potentials. It has been proposed that synaptopathy and HHL result in poor performance in challenging
Lingchao Ji, Beatriz C. Borges, David T. Martel, Calvin Wu, M. Charles Liberman, Susan E. Shore, Gabriel Corfas   +6 more
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The efferents interconnecting auditory inner hair cells

Hearing Research, 1994
The work describes the system of efferent terminals that interconnect inner hair cells through a chain of direct somatic synapses organized in repetitive patterns. The efferent boutons were discovered in the apical turns of 12-day-old (hearing) mice.
H M, Sobkowicz, S M, Slapnick
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Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells

Hearing Research, 1985
Cochleas of adult guinea pigs and rats, and 6-day-old rat pups, were injected, through the round window, with 2 microliters of artificial classical Konishi perilymph containing 1 nmol kainic acid (KA). 5 min later, they were fixed, removed, and processed for electron microscopy. In all KA-treated cochleas, the injection resulted in a severe swelling of
R, Pujol, M, Lenoir, D, Robertson, M, Eybalin, B M, Johnstone   +4 more
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A revised model of the inner-hair cell and auditory-nerve complex

The Journal of the Acoustical Society of America, 2002
A revised computational model of the inner-hair cell (IHC) and auditory-nerve (AN) complex is presented and evaluated. Building on previous models, the algorithm is intended as a component for use in more comprehensive models of the auditory periphery. It combines smaller components that aim to be faithful to physiology in so far as is practicable and ...
Christian J, Sumner, Enrique A, Lopez-Poveda, Lowel P, O'Mard, Ray, Meddis   +3 more
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Testing phenomenological auditory-nerve model predictions for selective inner- and outer-hair-cell dysfunction

The Journal of the Acoustical Society of America, 2023
Sensorineural hearing loss (SNHL) effects on neural coding and perception have been largely associated with outer-hair-cell (OHC) dysfunction (e.g., reduced cochlear gain, reduced compression, broadened tuning). However, both inner-hair-cell (IHC) and OHC dysfunction occur in common hearing-loss etiologies, e.g., noise-induced and age-related ...
Madhurima Patra, Andrew Sivaprakasam, David Axe, Michael G. Heinz   +3 more
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Simulation of the efficiency of inner hair cell secretion in the auditory pathway

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019
Sound coding involves several stages of processing along the auditory path. Specifically, the Inner Hair Cells (IHC) act as sensory receptors and transduce acoustic information -frequency, intensity and duration of the stimulus- into neuronal signals. In this work, a stochastic model was implemented to achieve a better understanding of the IHC-auditory
J, Soto, N, Castaneda-Villa, A, Gil, V, Gonzalez-Velez   +3 more
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The masking level difference in chinchilla auditory cortex. Effects of inner hair cell loss

Hearing Research, 2003
The purpose of the present study was to investigate responses from the unanesthetized chinchilla auditory cortex (AC) to conditions producing a masking level difference (MLD) in perceptual studies, both before and after inner hair cell (IHC) loss caused by carboplatin. Tungsten electrodes were chronically implanted in the right AC (active) and anterior
Yuqing, Guo, Robert, Burkard
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Two Modes of Auditory Hair Cell Loss following Acoustic Overstimulation in the Avian Inner Ear

ORL, 1997
To determine the type of cell death occurring and how the removal of damaged cells proceeds following overstimulation, we examined chick basilar papillae using an in situ DNA nick end labeling method and transmission electron microscopy. Two distinct modes of hair cell loss were identified.
T, Nakagawa, H, Yamane, S, Shibata, M, Takayama, K, Sunami, Y, Nakai   +5 more
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Phase opposition between inner and outer hair cells and auditory sound analysis

International Journal of Audiology, 1975
Recordings of single-unit responses in the auditory nerve of normal and kanamycin-treated Mongolian gerbils indicate that inner and outer hair cells of the cochlea interact in phase opposition. After kanamycin treatment, the firing rate in some fibers is increased during the basilar membrane motion toward scala vestibuli, in others, during its motion ...
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