Results 181 to 190 of about 15,322 (225)

The effects of the activation of the inner-hair-cell basolateral K+ channels on auditory nerve responses

Hearing Research, 2018
The basolateral membrane of the mammalian inner hair cell (IHC) expresses large voltage and Ca2+ gated outward K+ currents. To quantify how the voltage-dependent activation of the K+ channels affects the functionality of the auditory nerve innervating the IHC, this study adopts a model of mechanical-to-neural transduction in which the basolateral K ...
Pulkki, Ville, Verhulst, Sarah, Altoè, Alessandro   +3 more
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How are the Inner Hair Cells and Auditory Nerve Fibers Activated without the Mediation of the Outer Hair Cells and the Cochlear Amplifier?

Journal of Basic and Clinical Physiology and Pharmacology, 2010
The present study was designed to assess whether, in the presence of a depression of the cochlear amplifier i.e. a sensorineural hearing loss (SNHL), the inner hair cells (IHCs) require the presence of a normal endocochlear potential for transduction. An SNHL was induced by injecting salicylic acid (which binds to the motor protein prestin in the outer
Haim Sohmer, Cahtia Adelman, Jeffrey M Weinberger   +2 more
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The masking level difference in chinchilla auditory cortex. Effects of inner hair cell loss

Hearing Research, 2003
The purpose of the present study was to investigate responses from the unanesthetized chinchilla auditory cortex (AC) to conditions producing a masking level difference (MLD) in perceptual studies, both before and after inner hair cell (IHC) loss caused by carboplatin. Tungsten electrodes were chronically implanted in the right AC (active) and anterior
Robert Burkard, Yuqing Guo
openaire   +3 more sources

Compound synapses within the GABAergic innervation of the auditory inner hair cells in the adolescent mouse

The Journal of Comparative Neurology, 1997
Ultrastructural investigation of the gamma-aminobutyric acid (GABA) component of the inner spiral bundle in adolescent mice revealed a pathway of glutamic acid decarboxylase (GAD)-positive and -negative fibers and vesiculated endings that contact inner hair cells and their afferents through a complex of axosomatic and axodendritic synapses ...
Benjamin K. August, L. M. Nitecka, S. M. Slapnick, Hanna M. Sobkowicz   +3 more
openaire   +3 more sources

Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear

Hearing Research, 2020
Hair cells in the auditory organ of the vertebrate inner ear are the sensory receptors that convert acoustic stimuli into electrical signals that are conveyed along the auditory nerve to the brainstem. Hair cells are highly susceptible to ototoxic drugs, infection, and acoustic trauma, which can cause cellular degeneration.
Michael Lovett, Liangcai Wan, Mark E. Warchol, Jennifer S. Stone   +3 more
openaire   +3 more sources

Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells

Hearing Research, 1985
Cochleas of adult guinea pigs and rats, and 6-day-old rat pups, were injected, through the round window, with 2 microliters of artificial classical Konishi perilymph containing 1 nmol kainic acid (KA). 5 min later, they were fixed, removed, and processed for electron microscopy. In all KA-treated cochleas, the injection resulted in a severe swelling of
Marc Lenoir, Rémy Pujol, Brian M. Johnstone, Michel Eybalin, Donald Robertson   +4 more
openaire   +3 more sources

Phase opposition between inner and outer hair cells and auditory sound analysis

International Journal of Audiology, 1975
Recordings of single-unit responses in the auditory nerve of normal and kanamycin-treated Mongolian gerbils indicate that inner and outer hair cells of the cochlea interact in phase opposition. After kanamycin treatment, the firing rate in some fibers is increased during the basilar membrane motion toward scala vestibuli, in others, during its motion ...
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Distribution of the 275 kD hair cell antigen and cell surface specialisations on auditory and vestibular hair bundles in the chicken inner ear

Journal of Comparative Neurology, 1992
AbstractThe 275 kD hair cell antigen (HCA) is a protein that is specifically associated with the apical surface of sensory hair cells in the chick inner ear. A comparative study of the vestibular and auditory organs of the inner ear, using both wholemounts and cryosections double labelled for the HCA and F‐actin, reveals that two distinct types of hair
Guy P. Richardson, Richard J. Goodyear
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An Analog VLSI Implementation of the Inner Hair Cell and Auditory Nerve Using a Dual AGC Model

IEEE Transactions on Biomedical Circuits and Systems, 2014
An analog inner hair cell and auditory nerve circuit using a dual AGC model has been implemented using 0.35 micron mixed-signal technology. A fully-differential current-mode architecture is used and the ability to correct channel mismatch is evaluated with matched layouts as well as with digital current tuning.
Howard I. Cohen, Christian Karl, Socrates Deligeorges, Allyn E. Hubbard, David S. Freedman   +4 more
openaire   +3 more sources

Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice

Hearing Research, 2020
Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory nerve. Mutations in the tight junction protein Claudin 14 cause autosomal recessive non-syndromic hearing loss ...
J Schulze, Hans Gerd Nothwang, Maike Claußen   +2 more
openaire   +3 more sources