Results 21 to 30 of about 50,414 (231)

Research Progress on the Mechanism of Cochlear Hair Cell Regeneration

Frontiers in Cellular Neuroscience, 2021
Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss.
Shan Xu, Ning Yang
doaj   +1 more source

Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

eLife, 2020
Sound intensity is encoded by auditory neuron subgroups that differ in thresholds and spontaneous rates. Whether variations in neuronal biophysics contributes to this functional diversity is unknown.
Alexander L. Markowitz, Radha Kalluri
semanticscholar   +1 more source

Kölliker’s organ-supporting cells and cochlear auditory development

Frontiers in Molecular Neuroscience, 2022
The Kölliker’s organ is a transient cellular cluster structure in the development of the mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal cells in the internal sulcus at postnatal day 12 (P12)–P14, with the cochlea ...
Jianyong Chen, Jianyong Chen, Jianyong Chen, Dekun Gao, Dekun Gao, Dekun Gao, Lianhua Sun, Lianhua Sun, Lianhua Sun, Jun Yang, Jun Yang, Jun Yang   +11 more
doaj   +1 more source

Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells

Frontiers in Neuroscience, 2021
Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca, Marco Manca, Piece Yen, Paolo Spaiardi, Giancarlo Russo, Roberta Giunta, Stuart L. Johnson, Stuart L. Johnson, Walter Marcotti, Walter Marcotti, Sergio Masetto   +10 more
doaj   +1 more source

Sensory Transduction and Adaptation in Inner and Outer Hair Cells of the Mouse Auditory System [PDF]

Journal of Neurophysiology, 2007
Auditory function in the mammalian inner ear is optimized by collaboration of two classes of sensory cells known as inner and outer hair cells. Outer hair cells amplify and tune sound stimuli that are transduced and transmitted by inner hair cells. Although they subserve distinct functions, they share a number of common properties. Here we compare the
Jeffrey R. Holt, Eric A. Stauffer
openaire   +3 more sources

LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Cochlear hair cell loss is a leading cause of deafness in humans and other mammals. In the immature cochlea, lost hair cells are regenerated by neighboring glia-like supporting cells.
Xiao-Jun Li, Angelika Doetzlhofer
semanticscholar   +1 more source

Parallel Distribution of an Inner Hair Cell and Auditory Nerve Model for Real-Time Application [PDF]

IEEE Transactions on Biomedical Circuits and Systems, 2017
This paper summarizes recent efforts in implementing a model of the ear's inner hair cell and auditory nerve on a neuromorphic hardware platform, the SpiNNaker machine. This exploits the massive parallelism of the target architecture to obtain real-time modeling of a biologically realistic number of human auditory nerve fibres.
Robert James, Jim Garside, Michael Hopkins, Luis A. Plana, Steve Temple, Simon Davidson, Steve Furber   +6 more
openaire   +7 more sources

Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells [PDF]

, 2014
Mechanotransduction in the auditory and vestibular systems depends on mechanosensitive ion channels in the stereociliary bundles that project from the apical surface of the sensory hair cells.
Corns, Laura F, Johnson, Stuart L, Kros, Corné J, Marcotti, Walter   +3 more
core   +8 more sources

GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells

Development, 2020
Despite the known importance of the transcription factors ATOH1, POU4F3 and GFI1 in hair cell development and regeneration, their downstream transcriptional cascades in the inner ear remain largely unknown.
Maggie S. Matern, B. Milon, Erika L. Lipford, Mark McMurray, Yoko Ogawa, Andrew Tkaczuk, Yang Song, Ran Elkon, R. Hertzano   +8 more
semanticscholar   +1 more source

Remodeling of the Inner Hair Cell Microtubule Meshwork in a Mouse Model of Auditory Neuropathy AUNA1 [PDF]

eneuro, 2016
AbstractAuditory neuropathy 1 (AUNA1) is a form of human deafness resulting from a point mutation in the 5′ untranslated region of theDiaphanous homolog 3(DIAPH3) gene. Notably, theDIAPH3mutation leads to the overexpression of the DIAPH3 protein, a formin family member involved in cytoskeleton dynamics. Through study of diap3-overexpressing transgenic (
Surel, Clément, Guillet, Marie, Lenoir, Marc, Bourien, Jérôme, Sendin, Gaston, Joly, Willy, Delprat, Benjamin, Lesperance, Marci, Puel, Jean-Luc, Nouvian, Regis   +9 more
openaire   +3 more sources