Results 21 to 30 of about 50,821 (291)

Sensory Transduction and Adaptation in Inner and Outer Hair Cells of the Mouse Auditory System [PDF]

Journal of Neurophysiology, 2007
Auditory function in the mammalian inner ear is optimized by collaboration of two classes of sensory cells known as inner and outer hair cells. Outer hair cells amplify and tune sound stimuli that are transduced and transmitted by inner hair cells. Although they subserve distinct functions, they share a number of common properties. Here we compare the
Jeffrey R. Holt, Eric A. Stauffer
openaire   +3 more sources

Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells

Frontiers in Neuroscience, 2021
Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels.
Marco Manca, Marco Manca, Piece Yen, Paolo Spaiardi, Giancarlo Russo, Roberta Giunta, Stuart L. Johnson, Stuart L. Johnson, Walter Marcotti, Walter Marcotti, Sergio Masetto   +10 more
doaj   +1 more source

LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Cochlear hair cell loss is a leading cause of deafness in humans and other mammals. In the immature cochlea, lost hair cells are regenerated by neighboring glia-like supporting cells.
Xiao-Jun Li, Angelika Doetzlhofer
semanticscholar   +1 more source

GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells

Development, 2020
Despite the known importance of the transcription factors ATOH1, POU4F3 and GFI1 in hair cell development and regeneration, their downstream transcriptional cascades in the inner ear remain largely unknown.
Maggie S. Matern, B. Milon, Erika L. Lipford, Mark McMurray, Yoko Ogawa, Andrew Tkaczuk, Yang Song, Ran Elkon, R. Hertzano   +8 more
semanticscholar   +1 more source

Parallel Distribution of an Inner Hair Cell and Auditory Nerve Model for Real-Time Application [PDF]

IEEE Transactions on Biomedical Circuits and Systems, 2017
This paper summarizes recent efforts in implementing a model of the ear's inner hair cell and auditory nerve on a neuromorphic hardware platform, the SpiNNaker machine. This exploits the massive parallelism of the target architecture to obtain real-time modeling of a biologically realistic number of human auditory nerve fibres.
Robert James, Jim Garside, Michael Hopkins, Luis A. Plana, Steve Temple, Simon Davidson, Steve Furber   +6 more
openaire   +7 more sources

Mutations in ap1b1 Cause Mistargeting of the Na(+)/K(+)-ATPase Pump in Sensory Hair Cells. [PDF]

, 2013
The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle.
Clemens Grisham, Rachel, Finger-Baier, Karin, Kindt, Katie, Nicolson, Teresa, Schmid, Bettina   +4 more
core   +6 more sources

Development of otic organoids and their current status [PDF]

Organoid, 2023
The inner ear is responsible for both hearing and balance in the body, and since the initial development of otic (inner ear) organoids from mouse pluripotent stem cells (PSCs) in 2013, significant advances have been made in this field. Bone morphogenetic
Hantai Kim, Young Sun Kim, Yeon Ju Kim, Jungho Ha, Siung Sung, Jeong Hun Jang, Sunho Park, Jangho Kim, Kyunghoon Kim, Yun-Hoon Choung   +9 more
doaj   +1 more source

Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage

Frontiers in Cell and Developmental Biology, 2020
Aminoglycoside-induced hair cell (HC) loss is one of the most important causes of hearing loss. After entering the inner ear, aminoglycosides induce the production of high levels of reactive oxygen species (ROS) that subsequently activate apoptosis in ...
Z. Zhong, Xiaolong Fu, He Li, Jie Chen, Maohua Wang, Song Gao, Liyan Zhang, Cheng Cheng, Yuan Zhang, Peipei Li, Shasha Zhang, X. Qian, Y. Shu, R. Chai, Xia Gao   +14 more
semanticscholar   +1 more source

Remodeling of the Inner Hair Cell Microtubule Meshwork in a Mouse Model of Auditory Neuropathy AUNA1 [PDF]

eneuro, 2016
AbstractAuditory neuropathy 1 (AUNA1) is a form of human deafness resulting from a point mutation in the 5′ untranslated region of theDiaphanous homolog 3(DIAPH3) gene. Notably, theDIAPH3mutation leads to the overexpression of the DIAPH3 protein, a formin family member involved in cytoskeleton dynamics. Through study of diap3-overexpressing transgenic (
Surel, Clément, Guillet, Marie, Lenoir, Marc, Bourien, Jérôme, Sendin, Gaston, Joly, Willy, Delprat, Benjamin, Lesperance, Marci, Puel, Jean-Luc, Nouvian, Regis   +9 more
openaire   +3 more sources

Progressive auditory neuropathy in patients with Leber's hereditary optic neuropathy [PDF]

, 2004
Objective: To investigate auditory neural involvement in patients with Leber's hereditary optic neuropathy (LHON).Methods: Auditory assessment was undertaken in two patients with LHON.
Ceranic, B, Luxon, LM
core   +2 more sources