Results 91 to 100 of about 23,282 (228)

A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation

Cells, 2019
Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular ...
Kun Hou, Hui Jiang, Md. Rezaul Karim, Chao Zhong, Zhouwen Xu, Lin Liu, Minxin Guan, Jianzhong Shao, Xiao Huang   +8 more
doaj   +1 more source

Multi‐Frequency Electrocochleography Results in Fewer Drop Alarms During Cochlear Implant Insertion

The Laryngoscope, EarlyView.
A novel multi‐frequency electrocochleography (ECochG) algorithm used during cochlear implant electrode insertion is associated with fewer drop alarms and an increase in optimal insertion track patterns. Multi‐frequency ECochG may provide a more accurate assessment of the cochlear microenvironment when compared to single‐frequency ECochG.
Mana Espahbodi, Ali Syed, Alex Tu, Michael D. Seidman, Christopher J. Danner, Kyle P. Allen, Loren J. Bartels, Syed F. Ahsan, Courtney C.J. Voelker, Nicholas L. Deep, Jacob B. Hunter, Rebecca C. Chiffer, Elias M. Michaelides, Mohamed Elrakhawy, Matthew W. Miller, Harrison W. Lin, Hamid R. Djalilian, Esther X. Vivas, Simon I. Angeli, Michael Hoa, H. Jeffrey Kim, Mark H. Widick, Katrina R. Stidham, Neil S. Patel, Richard K. Gurgel, Karl W. Doerfer, Kanthaiah Koka, Michael S. Harris   +27 more
wiley   +1 more source

Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells

PLoS Biology, 2011
Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereocilium within a hair bundle is composed of uniformly polarized and tightly packed actin filaments. Several
V. Zampini, L. Rüttiger, S. L. Johnson, C. Franz, D. N. Furness, J. Waldhaus, H. Xiong, C. M. Hackney, M. C. Holley, N. Offenhauser, P.P. Di Fiore, M. Knipper, S. Masetto, W. Marcotti   +13 more
openaire   +6 more sources

Intervention Outcomes for Meniere's Disease: An Umbrella Review

The Laryngoscope, EarlyView.
ABSTRACT Objective To assess and summarize the outcomes of major pharmacologic, device‐based, and surgical interventions reported in systematic reviews and meta‐analyses for the treatment of Meniere's disease. Data Sources CINAHL, Cochrane, PubMed, Scopus.
Warren B. Chun, Shaun A. Nguyen, John F. Mills, Kaiwen Chen, Neil P. Monaghan, Emily A. Brennan, Jacqueline P. Nguyen, Ted A. Meyer   +7 more
wiley   +1 more source

Evaluation of the Hair Cell Regeneration in Zebrafish Larvae by Measuring and Quantifying the Startle Responses

Neural Plasticity, 2017
The zebrafish has become an established model organism for the study of hearing and balance systems in the past two decades. The classical approach to examine hair cells is to use dye to conduct selective staining, which shows the number and morphology ...
Changquan Wang, Zhenmin Zhong, Peng Sun, Hanbing Zhong, Hongzhe Li, Fangyi Chen   +5 more
doaj   +1 more source

Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley   +1 more source

Comorbidity Patterns Between Hearing Loss and Symptomatic Dizziness in Middle‐Aged and Older Adults

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To explore the comorbidity patterns between hearing loss and symptomatic dizziness (HL‐SD) in middle‐aged and older adults. Methods This cross‐sectional study used data from the 1999 to 2004 National Health and Nutrition Examination Survey (NHANES). After excluding incomplete data, 2961 participants aged 40–69 were analyzed. Logistic
Chun‐Yan Liu, Xiao‐Nan Wu, Jin Li, Jiao Zhang, Yun Gao, Da‐Yong Wang, Qiu‐Ju Wang   +6 more
wiley   +1 more source

Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An, Chen‐Yu Xu, Meng‐Ya Shen, Xiao‐Tao Guo, Chun‐Chen Pan, Jing‐Wu Sun, Xiao‐Min Tang, Jia‐Qiang Sun   +7 more
wiley   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Scientific Reports, 2018
Recent work has demonstrated that transmembrane channel-like 1 protein (TMC1) is an essential component of the sensory transduction complex in hair cells of the inner ear.
Yukako Asai, Bifeng Pan, Carl Nist-Lund, Alice Galvin, Andrei N. Lukashkin, Victoria A. Lukashkina, Tianwen Chen, Wu Zhou, Hong Zhu, Ian J. Russell, Jeffrey R. Holt, Gwenaelle S. G. Géléoc   +11 more
doaj   +1 more source