Results 81 to 90 of about 55,462 (279)

Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function [PDF]

, 2017
Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory nerve neurons are responsible ...
Goutman, Juan Diego
core   +1 more source

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, EarlyView.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

Role of the periotic mesenchyme in the development of sensory cells in early mouse cochlea

Journal of Otology, 2020
Objective: To investigate the role of the periotic mesenchyme (POM) in the development of sensory cells of developing auditory epithelium. Methods: Developing auditory epithelium with or without periotic mesenchyme was isolated from mice at embryonic ...
Jingjiang Huang, Na Zuo, Cheng Wu, Peipei Chen, Jun Ma, Chuanxi Wang, Wenyan Li, Shaofeng Liu   +7 more
doaj   +1 more source

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. [PDF]

, 2015
The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the 'cochlear amplifier' in each ear.
Cederholm, Jennie ME, Froud, Kristina E, Housley, Gary D, Julien, Jean-Pierre, Klugmann, Matthias, Ryan, Allen F, Sandow, Shaun L, Wong, Ann Chi Yan   +7 more
core   +2 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification.

PLoS Biology, 2023
Our sense of hearing is mediated by sensory hair cells, precisely arranged and highly specialized cells subdivided into outer hair cells (OHCs) and inner hair cells (IHCs).
Christopher J Buswinka, Richard T Osgood, Rubina G Simikyan, David B Rosenberg, Artur A Indzhykulian   +4 more
doaj   +1 more source

Proliferative generation of mammalian auditory hair cells in culture

Mechanisms of Development, 2002
Hair cell (HC) and supporting cell (SC) productions are completed during early embryonic development of the mammalian cochlea. This study shows that acutely dissociated cells from the newborn rat organ of Corti, developed into so-called otospheres consisting of 98% nestin (+) cells when plated on a non-adherent substratum in the presence of either ...
Malgrange, Brigitte, Belachew, Shibeshih, Thiry, Marc, Nguyen, Laurent, Rogister, Bernard, Alvarez Gonzalez, Maria-Luz, Rigo, Jean-Michel, Van de Water, Thomas R., Moonen, Gustave, Lefebvre, Philippe   +9 more
openaire   +2 more sources

Theoretical Conditions for High-Frequency Hair Bundle Oscillations in Auditory Hair Cells [PDF]

Biophysical Journal, 2008
Substantial evidence exists for spontaneous oscillations of hair cell stereociliary bundles in the lower vertebrate inner ear. Since the oscillations are larger than expected from Brownian motion, they must result from an active process in the stereociliary bundle suggested to underlie amplification of the sensory input as well as spontaneous ...
Nam, Jong-Hoon, Fettiplace, Robert
openaire   +2 more sources

Magnitude, Patterns and Factors Associated With Sensorineural Hearing Loss Among Hypertensive Adults at a Tertiary Hospital in Northern Tanzania

Eye &ENT Research, EarlyView.
ABSTRACT Background Hearing loss affects 1.5 billion people globally, with sensorineural hearing loss (SNHL) linked to hypertension. Hypertension affects 1.39 billion people worldwide and its prevalence is rising sharply in Sub‐Saharan Africa. While 12% of Tanzanian population has cardiovascular diseases, including hypertension and recent studies ...
Johnson Shayo, Denis Katundu, Abdallah Jonas, Peter Shija   +3 more
wiley   +1 more source

Live Demonstration: Real-time neuro-inspired sound source localization and tracking architecture applied to a robotic platform [PDF]

, 2018
This live demonstration presents a sound source localization and tracking system implemented with Spike Signal Processing (SSP) building blocks on FPGA devices.
Cerezuela Escudero, Elena, Jiménez Fernández, Ángel Francisco, Morgado Estévez, Arturo, Pérez Peña, Fernando   +3 more
core