Results 121 to 130 of about 22,677 (167)
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Adaptation in auditory hair cells
Current Opinion in Neurobiology, 2003The narrow stimulus limits of hair cell transduction, equivalent to a total excursion of about 100nm at the tip of the hair bundle, demand tight regulation of the mechanical input to ensure that the mechanoelectrical transducer (MET) channels operate in their linear range.
Robert, Fettiplace, Anthony J, Ricci
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Replacement of mammalian auditory hair cells
NeuroReport, 1998We investigated the potential for hair cell regeneration in neonatal rat organs of Corti grown in culture following destruction of hair cells by neomycin toxicity. Replacement hair cells were observed by light and scanning electron microscopy in lesion sites in the cultures treated with transforming growth factor-alpha, epidermal growth factor or a ...
A, Zine, F, de Ribaupierre
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Neurofilament proteins in avian auditory hair cells
The Journal of Comparative Neurology, 1997The distribution of middle-weight neurofilament protein (NF-M), an intermediate filament of neurons, was examined in the developing and mature avian inner ear by using immunocytochemical techniques. NF-M was detected in auditory hair cells and VIIIth cranial nerve neurons.
E C, Oesterle, D I, Lurie, E W, Rubel
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Apical phosphatidylserine externalization in auditory hair cells
Molecular Membrane Biology, 2007In hair cells of the inner ear, phosphatidylserine (PS), detected with fluorescent annexin V labeling, was rapidly exposed on the external leaflet of apical plasma membranes upon dissection of the organ of Corti. PS externalization was unchanged by caspase inhibition, suggesting that externalization did not portend apoptosis or necrosis.
Xiaorui, Shi +2 more
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The efferents interconnecting auditory inner hair cells
Hearing Research, 1994The work describes the system of efferent terminals that interconnect inner hair cells through a chain of direct somatic synapses organized in repetitive patterns. The efferent boutons were discovered in the apical turns of 12-day-old (hearing) mice.
H M, Sobkowicz, S M, Slapnick
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Auditory illusions and the single hair cell
Nature, 1993Like our other senses, the auditory system can produce illusions. Prominent among these are distortion products: when listening to two tones, one of frequency f1 and the second of a higher frequency f2, an individual may hear not only these primary tones, but also a difference tone of frequency f2 - f1, a sum tone of frequency f2 + f1, and combination ...
F, Jaramillo, V S, Markin, A J, Hudspeth
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Auditory hair cell innervational patterns in lizards
Journal of Comparative Neurology, 1988AbstractThe pattern of afferent and efferent innervation of two to four unidirectional (UHC) and two to nine bidirectional (BHC) hair cells of five different types of lizard auditory papillae was determined by reconstruction of serial TEM sections. The species studies were Crotaphytus wislizeni (iguanid), Podarcis (Lacerta) sicula and P.
M R, Miller, J, Beck
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Somatostatin and gentamicin‐induced auditory hair cell loss
The Laryngoscope, 2009AbstractObjective/Hypothesis:Hair cells of the mammalian auditory system do not regenerate, and therefore their loss leads to irreversible hearing loss. Aminoglycosides, among other substances, can irreversibly damage hair cells. Somatostatin, a peptide with hormone/neurotransmitter properties, has neuroprotective effects by binding to its receptor. In
Caelers, Antje +3 more
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Mechanosensitivity of mammalian auditory hair cells in vitro
Nature, 1986Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the excitatory mechanical input to these
I J, Russell, G P, Richardson, A R, Cody
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Hydrogen protects auditory hair cells from free radicals
NeuroReport, 2009Reactive oxygen species (ROS) play a role in the degeneration of auditory hair cells because of aging, noise trauma, or ototoxic drugs. Hydrogenation is a fundamental reduction/de-oxidation reaction in living organisms. This study thus examined the potential of hydrogen to protect auditory hair cells from ROS-induced damage. To generate ROS, we applied
Yayoi S, Kikkawa +3 more
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