Results 191 to 200 of about 23,282 (228)
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Mechanosensitivity of mammalian auditory hair cells in vitro
Nature, 1986Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the excitatory mechanical input to these
I J, Russell, G P, Richardson, A R, Cody
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The sensory and motor roles of auditory hair cells
Nature Reviews Neuroscience, 2006Cochlear hair cells respond with phenomenal speed and sensitivity to sound vibrations that cause submicron deflections of their hair bundle. Outer hair cells are not only detectors, but also generate force to augment auditory sensitivity and frequency selectivity.
Robert, Fettiplace, Carole M, Hackney
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The efferents interconnecting auditory inner hair cells
Hearing Research, 1994The work describes the system of efferent terminals that interconnect inner hair cells through a chain of direct somatic synapses organized in repetitive patterns. The efferent boutons were discovered in the apical turns of 12-day-old (hearing) mice.
H M, Sobkowicz, S M, Slapnick
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Somatostatin and gentamicin‐induced auditory hair cell loss
The Laryngoscope, 2009AbstractObjective/Hypothesis:Hair cells of the mammalian auditory system do not regenerate, and therefore their loss leads to irreversible hearing loss. Aminoglycosides, among other substances, can irreversibly damage hair cells. Somatostatin, a peptide with hormone/neurotransmitter properties, has neuroprotective effects by binding to its receptor. In
Caelers, Antje +3 more
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Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells
Neuroscience Bulletin, 2021Recent studies have revealed great functional and structural heterogeneity in the ribbon-type synapses at the basolateral pole of the isopotential inner hair cell (IHC). This feature is believed to be critical for audition over a wide dynamic range, but whether the spatial gradient of ribbon morphology is fine-tuned in each IHC and how the ...
Jing, Liu +8 more
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Sorting of actin isoforms in chicken auditory hair cells
Journal of Cell Science, 1997Most nonmuscle cells of higher vertebrates contain two different actin isoforms, beta- and gamma-cytoplasmic actin. The beta-isoform is with few exceptions the predominant isoform in nonmuscle cells and tissues. Perturbation of the beta:gamma ratio has been shown to affect the organization of bundled actin filaments indicating that the beta- and gamma ...
D, Höfer, W, Ness, D, Drenckhahn
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Two Components of Transducer Adaptation in Auditory Hair Cells
Journal of Neurophysiology, 1999Mechanoelectrical transducer currents in turtle auditory hair cells adapted to maintained stimuli via a Ca2+-dependent mechanism characterized by two time constants of ∼1 and 15 ms. The time course of adaptation slowed as the stimulus intensity was raised because of an increased prominence of the second component. The fast component of adaptation had a
Y C, Wu, A J, Ricci, R, Fettiplace
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Recent insights into regeneration of auditory and vestibular hair cells
Current Opinion in Neurology, 1998Advances in hair cell regeneration are progressing at a rapid rate. This review will highlight and critique recent attempts to understand some of the cellular and molecular mechanisms underlying hair cell regeneration in non-mammalian vertebrates and efforts to induce regeneration in the mammalian inner ear sensory epithelium.
J S, Stone, E C, Oesterle, E W, Rubel
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Mechanical and electromotile characteristics of auditory outer hair cells
Medical & Biological Engineering & Computing, 1999The passive and active properties of the cochlear outer hair cell are studied. The outer hair cell is currently considered the major candidate for the active component of mammalian hearing. Understanding of its properties may explain the amplification and sharp frequency selectivity of the ear.
A A, Spector, W E, Brownell, A S, Popel
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Auditory hair cells in human fetuses: Synaptogenesis and ciliogenesis
Journal of Electron Microscopy Technique, 1990AbstractThis paper brings together the most recent findings concerning the development of human fetus cochlear hair cells, as observed using transmission and scanning electron microscopy (TEM and SEM). Specific attention is drawn to the formation of synapses and the growth of stereocilia.
M, Lavigne-Rebillard, R, Pujol
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