Results 181 to 190 of about 55,462 (279)

Rate of Hearing Loss in Platinum‐Naïve Patients Receiving Immune Checkpoint Inhibitors

Otolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1289-1297, May 2026.
Abstract Objective Hearing loss from immune checkpoint inhibitors (ICIs) has been documented in case reports and case series. We present the largest retrospective study investigating the rate of ICI‐related ototoxicity in a monitored cohort of platinum‐naïve patients. Study Design Retrospective cohort study. Setting Tertiary‐care center.
Kaitlyn A. Brooks, Christopher G. Gidley, Olivia Grimley, Catherine Wang, Shirin Jivani, Dianna Roberts, Aung Naing, Jack Phan, Katherine Hutcheson, Xin Wang, Paul W. Gidley, Marc‐Elie Nader   +11 more
wiley   +1 more source

Human Alpha1-Antitrypsin Demonstrated Protective Effects Against Auditory Impairment in Murine Model of Noise-Induced Hearing Loss. [PDF]

OTO Open
Kaminer BM, El-Saied S, Abu Freh I, Amar A, Ziv O, Kaplan DM, Lewis EC.   +6 more
europepmc   +1 more source

Migraine Features in Patients With Sudden Sensorineural Hearing Loss

Otolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1263-1269, May 2026.
Abstract Objective To investigate the prevalence of migraine features among patients with sudden sensorineural hearing loss (SSNHL) and evaluate potential clinical associations. Study Design Retrospective survey‐based study. Setting Single institution tertiary care center. Methods 168 adult patients with SSNHL were recruited.
Yalda Yazdani, Ella J. Lee, Amanda Francis, Saharnaz Nedjat, Mehdi Abouzari, Hamid R. Djalilian   +5 more
wiley   +1 more source

Baicalin attenuates cisplatin-induced cochlear hair cell damage by modulating the ROS-p38 MAPK signaling pathway. [PDF]

Front Cell Dev Biol
Zhang Q, Wang Y, Zhang C, Li S, Yin Q, Zhou C, Dong C, Bu C.   +7 more
europepmc   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons. [PDF]

J Assoc Res Otolaryngol
Genitsaridi E, Papoutselou E, Campbell-Bell CM, Abbas L, Haines R, Hartley DEH, Rivolta MN.   +6 more
europepmc   +1 more source

From transporter to motor: Evolutionary and structural insights into the emergence of prestin's area‐motor activity in mammals

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Prestin, a member of the SLC26A family, is essential for the electromotility of mammalian outer hair cells, converting voltage changes into mechanical work. In contrast, nonmammalian orthologues function as anion transporters. To investigate the molecular and structural basis of this functional divergence, we performed ancestral sequence ...
Nicolás Fuentes‐Ugarte, Tiaren Ruiz‐Rojas, Felipe Garcia‐Olave, Alvaro Ruiz‐Fernandez, Jose Antonio Garate, Victor Castro‐Fernandez, Raul Araya‐Secchi   +6 more
wiley   +1 more source

Risk of Safety Events in Vitiligo Patients: A Retrospective Real‐World Data Study in the US

The Journal of Dermatology, Volume 53, Issue 5, Page 758-773, May 2026.
ABSTRACT Vitiligo is a chronic autoimmune depigmenting disease characterized by loss of pigment in the skin, hair, or both. As treatment options evolve, particularly with the emergence of oral Janus kinase inhibitors and dual Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor, it is essential to assess ...
Kennedy Cook, Nada M. Elbuluk, Roni Adiri, Alexandre Lejeune, Thomas Edwards, Milena A. Gianfrancesco, Scott P. Kelly, Tatjana Lukic, Edward Nagy, Samantha K. Kurosky, Lynne Napatalung, Iltefat Hamzavi   +11 more
wiley   +1 more source

Genetic and Environmental Factors Shaping Hearing Loss: Xenobiotics, Mechanisms and Translational Perspectives. [PDF]

J Xenobiot
Esteves F, Caria H.
europepmc   +1 more source

Dysmorphological and Neuropsychological Phenotypes of Prenatally Alcohol‐Exposed 6‐Year‐Old Children: A Prospective Longitudinal Birth Cohort Study

Alcohol, Clinical and Experimental Research, Volume 50, Issue 5, May 2026.
A prospective cohort study assessed 28 children with substantial prenatal alcohol exposure (PAE) and 52 controls at the age of 6. Most PAE children met Fetal Alcohol Spectrum Disorder (FASD) criteria, showing dysmorphic features, neurocognitive deficits, ADHD symptoms, and other health impairments. None had a prior diagnosis, demonstrating the need for
M. Jolma, E. Wallén, E. Saure, K. Rämö, H. Kahila, N. Kaminen‐Ahola   +5 more
wiley   +1 more source