Results 281 to 290 of about 119,470 (327)
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Adaptation in auditory hair cells
Current Opinion in Neurobiology, 2003The narrow stimulus limits of hair cell transduction, equivalent to a total excursion of about 100nm at the tip of the hair bundle, demand tight regulation of the mechanical input to ensure that the mechanoelectrical transducer (MET) channels operate in their linear range.
Anthony J. Ricci, Robert Fettiplace
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Replacement of mammalian auditory hair cells
NeuroReport, 1998We investigated the potential for hair cell regeneration in neonatal rat organs of Corti grown in culture following destruction of hair cells by neomycin toxicity. Replacement hair cells were observed by light and scanning electron microscopy in lesion sites in the cultures treated with transforming growth factor-alpha, epidermal growth factor or a ...
F de Ribaupierre, Azel Zine
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Auditory illusions and the single hair cell
Nature, 1993Like our other senses, the auditory system can produce illusions. Prominent among these are distortion products: when listening to two tones, one of frequency f1 and the second of a higher frequency f2, an individual may hear not only these primary tones, but also a difference tone of frequency f2 - f1, a sum tone of frequency f2 + f1, and combination ...
V. S. Markin +2 more
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Mechanosensitivity of mammalian auditory hair cells in vitro
Nature, 1986Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the excitatory mechanical input to these
A. R. Cody +2 more
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Apical phosphatidylserine externalization in auditory hair cells
Molecular Membrane Biology, 2007In hair cells of the inner ear, phosphatidylserine (PS), detected with fluorescent annexin V labeling, was rapidly exposed on the external leaflet of apical plasma membranes upon dissection of the organ of Corti. PS externalization was unchanged by caspase inhibition, suggesting that externalization did not portend apoptosis or necrosis.
Xiaorui Shi +2 more
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The efferents interconnecting auditory inner hair cells
Hearing Research, 1994The work describes the system of efferent terminals that interconnect inner hair cells through a chain of direct somatic synapses organized in repetitive patterns. The efferent boutons were discovered in the apical turns of 12-day-old (hearing) mice.
Hanna M. Sobkowicz, S. M. Slapnick
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Auditory hair cell innervational patterns in lizards
Journal of Comparative Neurology, 1988AbstractThe pattern of afferent and efferent innervation of two to four unidirectional (UHC) and two to nine bidirectional (BHC) hair cells of five different types of lizard auditory papillae was determined by reconstruction of serial TEM sections. The species studies were Crotaphytus wislizeni (iguanid), Podarcis (Lacerta) sicula and P.
Malcolm R. Miller, Janet Beck
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Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells
Neuroscience Bulletin, 2021Recent studies have revealed great functional and structural heterogeneity in the ribbon-type synapses at the basolateral pole of the isopotential inner hair cell (IHC). This feature is believed to be critical for audition over a wide dynamic range, but whether the spatial gradient of ribbon morphology is fine-tuned in each IHC and how the ...
Shengxiong Wang +11 more
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Auditory Hair Cells and Sensory Transduction
2017The organs of the vertebrate inner ear respond to a variety of mechanical stimuli: semicircular canals are sensitive to angular velocity, the saccule and utricle respond to linear acceleration (including gravity), and the cochlea is sensitive to airborne vibration, or sound.
Jeffrey R. Holt +1 more
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Somatostatin and gentamicin‐induced auditory hair cell loss
The Laryngoscope, 2009AbstractObjective/Hypothesis:Hair cells of the mammalian auditory system do not regenerate, and therefore their loss leads to irreversible hearing loss. Aminoglycosides, among other substances, can irreversibly damage hair cells. Somatostatin, a peptide with hormone/neurotransmitter properties, has neuroprotective effects by binding to its receptor. In
Caelers, Antje +3 more
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