Results 281 to 290 of about 475,797 (351)

Transient capacitance changes recorded from vestibular type I hair cells are produced by G_K,L gating and do not involve neurotransmitter exocytosis. [PDF]

J Physiol
Spaiardi P, Giunta R, Rispoli G, Masetto S, Johnson SL.   +4 more
europepmc   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

The role of cilia in the development, survival, and regeneration of hair cells. [PDF]

Biol Open
Boldizar H, Friedman A, Stanley T, Padilla M, Galdieri J, Sclar A, Stawicki TM.   +6 more
europepmc   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells

Advanced Science, EarlyView.
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot, Laure Stickel, Pascal Martin   +2 more
wiley   +1 more source

Revisiting the Potency of Tbx2 Expression in Transforming Outer Hair Cells into Inner Hair Cells at Multiple Ages In Vivo. [PDF]

J Neurosci
Bi Z, Ren M, Zhang Y, He S, Song L, Li X, Liu Z.   +6 more
europepmc   +1 more source

Ecosystem‐Centered Robot Design: Toward Ecoresorbable Sustainability Robots (ESRs)

Advanced Science, EarlyView.
Robots exploring natural ecosystems can support monitoring and conservation, but must adopt ecosystem‐centered design to avoid pollution, waste, and damage. This review proposes guidelines for co‐designing ecoresorbable sustainability robots (ESRs), uniting materials, robotics, and ecological contexts in a single framework.
Tülin Yılmaz Nayır, Yuan Fang, Consuelo Contreras, Andrew K. Schulz, Florian Hartmann   +4 more
wiley   +1 more source

MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea. [PDF]

Proc Natl Acad Sci U S A
Underhill A, Webb S, Grandi FC, Jeng JY, de Monvel JB, Plion B, Carlton AJ, Amariutei AE, Voulgari N, De Faveri F, Ceriani F, Mustapha M, Johnson SL, Safieddine S, Kros CJ, Marcotti W.   +15 more
europepmc   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Influence of Myosin Regulatory Light Chain and Myosin Light Chain Kinase on the Physiological Function of Inner Ear Hair Cells. [PDF]

J Assoc Res Otolaryngol
Oya R, Woo KM, Fabella B, Alonso RG, Bravo P, Hudspeth AJ.   +5 more
europepmc   +1 more source