Results 281 to 290 of about 10,997,299 (381)

Amiloride blocks the mechano‐electrical transduction channel of hair cells of the chick.

, 1988
Finn Stener Jørgensen, Harunori Ohmori
openalex   +2 more sources

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

BRCA1 Promotes Repair of DNA Damage in Cochlear Hair Cells and Prevents Hearing Loss. [PDF]

J Neurosci
Jiang W, Wang G, Bai F, Hu B, Xu Y, Xu X, Nie G, Zhu WG, Chen F, Pei XH.   +9 more
europepmc   +1 more source

Efferent modulation of hair cell tuning in the cochlea of the turtle.

, 1985
Jonathan Art, A. C. Crawford, Robert Fettiplace, Paul Fuchs   +3 more
openalex   +2 more sources

Over Half the Hair Cells in the Mouse Utricle First Appear After Birth, with Significant Numbers Originating from Early Postnatal Mitotic Production in Peripheral and Striolar Growth Zones

Journal of the Association for Research in Otolaryngology, 2012
Joseph C. Burns, D. On, Wendy Baker, M. S. Collado, J. Corwin   +4 more
semanticscholar   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells. [PDF]

JCI Insight
O'Connor AP, Amariutei AE, Zanella A, Hool SA, Carlton AJ, Kong F, Saenz-Roldan M, Jeng JY, Lecomte MJ, Johnson SL, Safieddine S, Marcotti W.   +11 more
europepmc   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells.

Development
Jukic A, Lei Z, Cebul ER, Pinter K, Tadesse Y, Jarysta A, David S, Mosqueda N, Tarchini B, Kindt K.   +9 more
europepmc   +1 more source

Molecular specializations underlying phenotypic differences in inner ear hair cells of zebrafish and mice. [PDF]

Front Neurol
Giffen KP, Liu H, Yamane KL, Li Y, Chen L, Kramer KL, Zallocchi M, He DZ.   +7 more
europepmc   +1 more source