Results 31 to 40 of about 10,895,649 (358)
Hair Cell Generator Potentials [PDF]
The Journal of General Physiology, 1973 A technique is introduced using a piezoelectric device to stimulate hair cells of a molluscan statocyst while recording their responses intracellularly. Statocyst displacements produced with the technique are calibrated with stroboscopic photography. Properties of the hair cells' response to currents and mechanical stimulation are studied.
Daniel L. Alkon, Anthony F. Bak
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Scientific Reports, 2017 The use of viral vectors for inner ear gene therapy is receiving increased attention for treatment of genetic hearing disorders. Most animal studies to date have injected viral suspensions into neonatal ears, via the round window membrane.
Jun Suzuki +9 more
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Magnetic actuation of hair cells [PDF]
Applied Physics Letters, 2011 The bullfrog sacculus contains mechanically sensitive hair cells whose stereociliary bundles oscillate spontaneously when decoupled from the overlying membrane. Steady-state offsets on the resting position of a hair bundle can suppress or modulate this native motility.
Jae Hyun Lee +4 more
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Stem Cell Research & Therapy, 2018 Background Inner ear hair cells as mechanoreceptors are extremely important for hearing. Defects in hair cells are a major cause of deafness. Induced pluripotent stem cells (iPSCs) are promising for regenerating inner ear hair cells and treating hearing ...
Jianling Chen +7 more
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Scientific Reports, 2022 Stimulation of hair growth in hair loss has been a difficult goal to achieve. Hair follicle-associated pluripotent (HAP) stem cells express nestin and have been shown to differentiate to multiple cell types including keratinocytes, neurons, beating ...
Koya Obara +7 more
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Molecular Therapy: Methods & Clinical Development, 2022 The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively ...
Jing-Yi Jeng +12 more
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CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
Nature Communications, 2017 Inner ear hair cells detect sound through deflection of stereocilia, the microvilli-like projections that are arranged in rows of graded heights. Calcium and integrin-binding protein 2 is essential for hearing and localizes to stereocilia, but its exact ...
A. Giese +12 more
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Effects of DAPT and Atoh1 overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats. [PDF]
PLoS ONE, 2011 BACKGROUND: In mammals, hair cells do not undergo spontaneous regeneration when they are damaged and result in permanent hearing loss. Previous studies in cultured Organ of Corti dissected from neonatal animals have shown that both DAPT (r-secretase ...
Li-Dong Zhao +11 more
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Hair Graying Regulators Beyond Hair Follicle
Frontiers in Physiology, 2022 Hair graying is an interesting physiological alteration associated with aging and certain diseases. The occurrence is due to depigmentation of the hair caused by depletion and dysfunction of melanocyte stem cells (MeSCs).
Jing Chen +8 more
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Outer Hair Cells and Electromotility [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Outer hair cells (OHCs) of the mammalian cochlea behave like actuators: they feed energy into the cochlear partition and determine the overall mechanics of hearing. They do this by generating voltage-dependent axial forces. The resulting change in the cell length, observed by microscopy, has been termed "electromotility." The mechanism of force ...
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