Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]
PLoS ONE, 2014 To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke +7 more
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Hair-bearing human skin generated entirely from pluripotent stem cells
bioRxiv, 2019 The skin is a multilayered organ, equipped with appendages (that is, follicles and glands), that is critical for regulating body temperature and the retention of bodily fluids, guarding against external stresses and mediating the sensation of touch and ...
Jiyoon Lee +10 more
semanticscholar +1 more source
Two adaptation processes in auditory hair cells together can provide an active amplifier [PDF]
, 2003 The hair cells of the vertebrate inner ear convert mechanical stimuli to electrical signals. Two adaptation mechanisms are known to modify the ionic current flowing through the transduction channels of the hair bundles: a rapid process involves calcium ...
Andrej Vilfan +42 more
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Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. [PDF]
, 2015 Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
Axon, P +12 more
core +1 more source
Cell Journal, 2017 Objective Dermal papilla and hair epithelial stem cells regulate hair formation and the growth cycle. Damage to or loss of these cells can cause hair loss.
Mohammadali Nilforoushzadeh +7 more
doaj +1 more source
Unlocking the vital role of host cells in hair follicle reconstruction by semi-permeable capsules. [PDF]
PLoS ONE, 2017 Organ regeneration is becoming a promising choice for many patients; however, many details about the mechanisms underlying organ regeneration remain unknown.
Zhexiang Fan +7 more
doaj +1 more source
The challenge of hair cell regeneration [PDF]
Experimental Biology and Medicine, 2010 Sensory hair cells of the inner ear are responsible for translating auditory or vestibular stimuli into electrical energy that can be perceived by the nervous system. Although hair cells are exquisitely mechanically sensitive, they can be easily damaged by excessive stimulation by ototoxic drugs and by the effects of aging.
openaire +2 more sources
Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. [PDF]
, 2015 The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the 'cochlear amplifier' in each ear.
Cederholm, Jennie ME +7 more
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Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance
Scientific Reports, 2017 The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback.
Nikola Ciganović +2 more
doaj +1 more source
Tuning in to cochlear hair cells [PDF]
The Journal of Physiology, 2006 A major quest in hearing research over the last 35 years or so has been, and continues to be, how mammalian hearing achieves its remarkable frequency selectivity and sensitivity over a large frequency range, down from 20 Hz up to over 100 kHz in some species.
Michael G. Evans, Corné J. Kros
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