Ticagrelor washout bridged with GPIIb/IIIa inhibitor infusion to facilitate surgical care following placement of pipeline flow diverters: a case report [PDF]
Journal of Neurocritical Care, 2023 Background Pipeline flow diverters (PFDs) are becoming increasingly common. Antiplatelet medication is required to minimize periprocedural ischemic events.
Aaron Zweig +4 more
doaj +1 more source
Chemical Strategies for Half-Life Extension of Biopharmaceuticals: Lipidation and Its Alternatives.
ACS Medicinal Chemistry Letters, 2018 Strategies for half-life extension are often required in the design of new biopharmaceuticals. This Viewpoint focuses on chemical moieties that convey protraction by albumin binding or by self-assembly to form larger structures, with GLP-1 and insulin as
Esben M. Bech +2 more
semanticscholar +1 more source
In silico approaches for predicting the half-life of natural and modified peptides in blood
PLoS ONE, 2018 This paper describes a web server developed for designing therapeutic peptides with desired half-life in blood. In this study, we used 163 natural and 98 modified peptides whose half-life has been determined experimentally in mammalian blood, for ...
Deepika Mathur +4 more
semanticscholar +1 more source
Extending human IgG half-life using structure-guided design
mAbs, 2018 Engineering of antibodies for improved pharmacokinetics through enhanced binding to the neonatal Fc receptor (FcRn) has been demonstrated in transgenic mice, non-human primates and humans.
B. Booth +6 more
semanticscholar +1 more source
A new precision measurement of the {\alpha}-decay half-life of 190Pt
, 2017 A laboratory measurement of the $\alpha$-decay half-life of $^{190}$Pt has been performed using a low background Frisch grid ionisation chamber. A total amount of 216.60(17) mg of natural platinum has been measured for 75.9 days.
Braun, Miháy +4 more
core +2 more sources
Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins.
Current pharmaceutical design, 2019 Peptides and proteins are two classes of molecules with attractive possibilities for therapeutic applications. However, the bottleneck for the therapeutic application of many peptides and proteins is their short halflives in vivo, typically just a few ...
Huanbo Tan +5 more
semanticscholar +1 more source
Effects of chronic browsing on life‐history traits of an irruptive large herbivore population
Population Ecology, EarlyView.This study aimed to determine the relationship between diet quality, body mass, and size (hind foot length), and female reproduction and sought to identify the mechanism by which high density under severe food limitations is maintained. Our results demonstrated that sika deer introduced to Nakanoshima Island have maintained high densities through high ...
Koichi Kaji +9 more
wiley +1 more source
Precise half-life measurement of 110Sn and 109In isotopes
, 2005 The half-lives of 110Sn and 109In isotopes have been measured with high precision. The results are T1/2 =4.173 +- 0.023 h for 110Sn and T1/2 = 4.167 +-0.018 h for 109In.
A. Palumbo +10 more
core +1 more source
Half-life of the electron-capture decay of 97Ru: Precision measurement shows no temperature dependence [PDF]
, 2009 We have measured the half-life of the electron-capture (ec) decay of 97Ru in a metallic environment, both at low temperature (19K), and also at room temperature. We find the half-lives at both temperatures to be the same within 0.1%.
D. J. Silvester +7 more
core +2 more sources
Fenobody: A Ferritin-Displayed Nanobody with High Apparent Affinity and Half-Life Extension.
Analytical Chemistry, 2018 Nanobodies consist of a single domain variable fragment of a camelid heavy-chain antibody. Nanobodies have potential applications in biomedical fields because of their simple production procedures and low cost.
Kelong Fan +8 more
semanticscholar +1 more source