Results 51 to 60 of about 1,585,431 (199)

Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model

Journal of Investigative Surgery, 2017
Purpose/aim of the study: The pharmacokinetic (PK) parameters in animal models can help optimize novel candidate drugs prior to human trials. However, due to the complexity of pharmacokinetic experiments, their use is limited in academia.
Ioannis Christakis, Rebecca Scott, James Minnion, Joyceline Cuenco, Tricia Tan, Fausto Palazzo, Stephen Bloom   +6 more
doaj   +1 more source

Development of a Novel Scaffold of Chitosan, Type IV Collagen and Integrin α3β1 As Alternative Scaffold for Primary Culture of Podocytes

Applied Sciences, 2018
Loss of podocytes has been a main pathology present in renal diseases; the leak of these specialized cells increases the permeability of the glomerular basal membrane (GMB) and protein release affecting the glomeruli, the main structure of the kidney ...
Diana Ginette Zárate-Triviño, Sara Paola Hernández-Martínez, Juan José Bollain-y-Goytia-de-la-Rosa, Moisés Armides Franco-Molina, Eduardo Arturo Elizalde-Peña, Margarita Idalia Hernández-Villegas, Gloria Azucena Rangel-Ochoa, Cristina Rodríguez-Padilla   +7 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Bioavailability and remineralization rates of sediment-derived dissolved organic carbon from a Baltic Sea depositional area

Frontiers in Marine Science
This pilot study investigated the bioavailability and remineralization kinetics of the sediment-derived dissolved organic carbon (DOC) from the Gdańsk Deep, a depositional area in the Baltic Sea.
Monika Lengier, Katarzyna Koziorowska-Makuch, Beata Szymczycha, Karol Kuliński   +3 more
doaj   +1 more source

Determination of the energy transitions and half-lives of Rubidium nuclei

Open Physics, 2018
The photonuclear reactions, first extensively studied in the 1970’s and performed using the gamma rays obtained via bremsstrahlung, are a standard nuclear physics experiment.
Biçer Ahmet, Manisa Kaan, Engin Çalık Abdullah, Erdoğan Mehmet, Şen Mürsel, Bircan Hasan, Dapo Haris, Boztosun Ismail   +7 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Methods for deriving the law of radioactive decay and the law of radiation absorption using the property of the exponent function when studying Physics in the system of secondary vocational education

Вестник Майкопского государственного технологического университета
In accordance with the educational standards of the Federal State Educational Standard for Secondary Professional Education, it is intended to familiarize students of professional educational organizations with the properties of radioactive radiation ...
D. B. Siyukhova, T. I. Demina
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Toxicological, Chemical, Social, and Economic Challenges Associated with PFAS and Replacement Aqueous Film-Forming Foams (AFFF)

Toxics
Poly- and perfluorinated alkyl substances (PFAS) are a group of chemicals that are widely used, prevalent in the environment, associated with several toxic effects, and often have long half-lives.
William S. Baldwin, Michael S. Bloom, Katy W. Chung, Subham Dasgupta, Marie E. DeLorenzo, Kelly J. Hunt, Peter B. Key, John L. Pearce, Kylie D. Rock, Philip Tanabe, Morgan A. Jacobellis, Melanie M. Garcia, Lisa J. Bain   +12 more
doaj   +1 more source

Is There Any Regional Price Disparity in Peninsular Malaysia? [PDF]

Romanian Review of Regional Studies, 2015
This study examines whether there are significant differences in prices across four regions in Peninsular Malaysia, namely Northern, Central, Southern, and Eastern Peninsular Malaysia. Disaggregate monthly consumer price indices for twelve types of goods
LEE CHIN
doaj