Results 61 to 70 of about 61,813 (248)

Chinese Expert Consensus on Integrated Chinese and Western Medicine for the Treatment of Tic Disorders. [PDF]

J Evid Based Med
ABSTRACT Objective Tic disorders are neurodevelopmental conditions that manifest in childhood or adolescence and can significantly impact the quality of life of affected children and their families to varying degrees. Integrated traditional Chinese and Western medicine treatment strategies have demonstrated more pronounced efficacy and better safety ...
Ma R, Wang S, Zheng Y, Chen J, Chen W, Cui X, Cui Y, Guo Y, Han F, Han X, Wang D, He F, Rong P, Hu Y, Huang Y, Ke X, Li B, Li M, Li R, Liu H, Liu J, Liu Z, Luo X, Ma B, Shi P, Sun J, Wang H, Wu L, Wu M, Yan H, Zhang B, Zhang J, Zhang J, Zhang X, Zhang X, Standard Research Project Group on Prevention and Treatment Strategies of Integrated Chinese and Western Medicine.   +35 more
europepmc   +2 more sources

Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: a randomized clinical trial.

Journal of the American Medical Association (JAMA), 2014
IMPORTANCE Long-acting injectable antipsychotics are used to reduce medication nonadherence and relapse in schizophrenia-spectrum disorders. The relative effectiveness of long-acting injectable versions of second-generation and older antipsychotics has ...
J. McEvoy, M. Byerly, Robert M. Hamer, R. Dominik, M. Swartz, Robert A. Rosenheck, Neepa Ray, J. S. Lamberti, Peter F. Buckley, Tania M Wilkins, T. Stroup   +10 more
semanticscholar   +1 more source

Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands

ChemMedChem, EarlyView.
This study highlights the tetrahydropyrrolo[3,4‐c]pyrazole scaffold as a promising platform for S1R ligands development. Key findings include compound 19’s high S1R affinity (Ki=75 nM), influenced by strategic nitrogen substitutions and reduced steric hindrance.
Giuseppe Cosentino, Maria Dichiara, Giuliana Costanzo, Alessandro Coco, Lorella Pasquinucci, Agostino Marrazzo, Antonio Rescifina, Emanuele Amata   +7 more
wiley   +1 more source

Effect of the antipsychotic drug haloperidol on arrhythmias during acute myocardial infarction in a porcine model

International Journal of Cardiology: Heart & Vasculature, 2020
Patients receiving psychiatric medication, like the antipsychotic drug haloperidol, are at an increased risk of sudden cardiac death (SCD). Haloperidol blocks the cardiac rapidly-activating delayed rectifier potassium current, thereby increasing ...
Stefan M. Sattler, Anniek F. Lubberding, Charlotte B. Kristensen, Rasmus Møgelvang, Paul Blanche, Anders Fink-Jensen, Thomas Engstrøm, Stefan Kääb, Thomas Jespersen, Jacob Tfelt-Hansen   +9 more
doaj  

Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects

Palliative & Supportive Care, 2014
Objective: The aim of this study was to compare the efficacy and side-effect profile of the typical antipsychotic haloperidol with that of the atypical antipsychotics risperidone, olanzapine, and aripiprazole in the management of delirium.
Soenke Boettger, J. Jenewein, W. Breitbart   +2 more
semanticscholar   +1 more source

Effects of gestational haloperidol exposure on mRNA expressions related to glutamate and GABA receptors in offspring

IBRO Neuroscience Reports, 2023
Antipsychotic treatment is vital for patients with schizophrenia even in the perinatal period, but the impact at the molecular biological level on offspring is unclear.
Hiroshi Kumon, Yuta Yoshino, Yu Funahashi, Shinichiro Ochi, Jun-ichi Iga, Shu-ichi Ueno   +5 more
doaj  

Haloperidol for the treatment of nausea and vomiting in palliative care patients.

Cochrane Database of Systematic Reviews, 2014
BACKGROUND Nausea and vomiting are common symptoms in patients with terminal, incurable illnesses. Both nausea and vomiting can be distressing. Haloperidol is commonly prescribed to relieve these symptoms.
F. Murray-Brown, S. Dorman
semanticscholar   +1 more source

Impact of Regulatory Post‐Market Safety Advisories on Prescribing Practices: An Interrupted Time Series Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Less frequent adverse drug reactions are usually discovered after a drug's release to the market, making effective and timely communication of regulatory post‐market advisories essential for preventing emerging adverse effects. Time series analysis is a key study design for assessing the impact of post‐market safety advisories.
Seonji Kim, Subin Kim, Chungsoo Kim, Junhyuk Chang, Rae Woong Park, Kyung Won Kim, Seng Chan You   +6 more
wiley   +1 more source

Multianalyte Approach—Including Automated Preparation of Calibrators—for Validated Quantification of 82 Drugs in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
In forensic bioanalysis, often multianalyte approaches are used given their increased effectiveness but can be difficult to develop and maintain in the laboratory, for example, in terms of calibrator solution preparation. A fast, simple, and robust liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the quantification of 82 classic ...
Andrea E. Steuer, Maja Keller, Thomas Kraemer, Sandra N. Poetzsch   +3 more
wiley   +1 more source

Antipsychotic Drugs Reverse MK801-Inhibited Cell Migration and F-actin Condensation by Modulating the Rho Signaling Pathway in B35 Cells

Behavioural Neurology, 2020
Background and Aim. MK801-induced psychotic symptoms and also the Ras homolog family member A (RhoA) expression and cell division control protein 42 (cdc42) mRNA modulation in the rat brain have been investigated.
Yi-Chyan Chen, Fu-Ming Tsai, Mao-Liang Chen   +2 more
doaj   +1 more source