Results 181 to 190 of about 37,629 (254)

Hyperglycaemia as a predictor of morbidity and mortality in patients receiving an allogeneic haematopoietic stem cell transplantation

British Journal of Haematology, EarlyView.
Summary Allogeneic haematopoietic stem cell transplantation (allo‐HSCT) is an effective treatment for patients with haematological malignancies; however, post‐transplant complications, including infections and acute graft‐versus‐host disease (aGvHD), remain significant issues. Identifying modifiable risk factors is therefore critical to improve patient
Marieke Tienstra, Fleur R. Goemans, Kylie Keijzer, Inge V. G. Oteman, Carin L. E. Hazenberg, Jaap A. van Doesum, Anne G. H. Niezink, Goda Choi, Gerwin A. Huls, Peter R. van Dijk, Hilde A. M. Kooistra, Tom van Meerten, Linde M. Morsink   +12 more
wiley   +1 more source

Identification of antidepressant response-related changes to DNA methylation and gene expression. [PDF]

Int J Neuropsychopharmacol
Fiori LM, Nagy C, Turecki G.
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Nutritional frailty and sarcopenia risk among older Somali refugee returnees: an overlooked crisis at the intersection of displacement, aging, and food insecurity. [PDF]

J Nutr Health Aging
Hussein MA, Mohamed SA, Khalif IA, Mohamud SZ, Mohamed HA.   +4 more
europepmc   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

HTLV-1 genetic diversity of 52 complete sequences from 14 African countries reveals novel variants and a lack of typical P12/P8 and P30 accessory proteins in HTLV-1b, d, and f genotypes. [PDF]

Emerg Microbes Infect
Cassar O, Djuicy DD, Begliomini G, Ramassamy JL, Oloumbou EF, Mouinga-Ondeme A, Njouom R, Marcais A, Deruelle E, Hermine O, Soriano V, de Mendoza C, Taylor G, Afonso PV, Gessain A.   +14 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Progressive abnormal gait in an adult Jack Russell Terrier with a homozygous frameshift variant in SETX (senataxin). [PDF]

J Vet Intern Med
Shelton GD, Bhatti SFM, Van Ham L, Friedenberg SG, Cullen JN, Guo LT, Minor KM.   +6 more
europepmc   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Brexanolone infusion produces sustained anti-inflammatory and neurotrophic effects in patients with postpartum depression that predict symptom improvement. [PDF]

Transl Psychiatry
Balan I, Pearson CIS, Krohn H, O'Buckley TK, Xia K, Meltzer-Brody S, Morrow AL, Patterson R.   +7 more
europepmc   +1 more source