Results 121 to 130 of about 290,368 (328)

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement[S]

Journal of Lipid Research, 2013
Delta-5 and delta-6 desaturases (D5D and D6D) are key enzymes in endogenous synthesis of long-chain PUFAs. In this sample of healthy subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1 ...
Maryam Al-Hilal, Aseel AlSaleh, Zoitsa Maniou, Fiona J. Lewis, Wendy L. Hall, Thomas A.B. Sanders, Sandra D. O'Dell   +6 more
doaj  

Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever

Frontiers in Immunology, 2018
Rheumatic fever (RF) and its subsequent progression to rheumatic heart disease (RHD) are chronic inflammatory disorders prevalent in children and adolescents in underdeveloped countries, and a contributing factor for high morbidity and mortality rates ...
Sandra Jeremias Catarino, Fabiana Antunes Andrade, Angelica Beate Winter Boldt, Angelica Beate Winter Boldt, Luiza Guilherme, Iara Jose Messias-Reason   +5 more
doaj   +1 more source

THE IMMUNOGENICITY OF HUMAN HL-A HAPLOTYPES AS MEASURED BY SKIN GRAFT SURVIVAL TIMES AND MIXED LEUKOCYTE REACTIONS [PDF]

, 1971
Seigler Hf, Frances E. Ward, D. Bernard Amos, M. B. Phaup, Delford L. Stickel   +4 more
openalex   +1 more source

Real‐world study on fluoropyrimidine‐related toxicity outcomes in cancer patients with select DPYD variant alleles that received DPYD genotype‐guided dosing

International Journal of Cancer, EarlyView.
What's New? Fluoropyrimidines, a key component of chemotherapy regimens for a variety of solid tumors, can cause severe toxicity. Patients who have specific genetic variants in the DPYD gene, which encodes an enzyme that inactivates fluoropyrimidines, have increased susceptibility to this toxicity.
Sofía L. J. Peeters, Didier Meulendijks, Zerina Kadric, Sara Ibrovic, Geert‐Jan Creemers, Vanja Milosevic, Matthijs van de Poll, Lieke H. J. Simkens, Birgit A. L. M. Deiman, Hans Gelderblom, Henk‐Jan Guchelaar, Anna M. J. Thijs, Maarten J. Deenen   +12 more
wiley   +1 more source

Extended major histocompatibility complex haplotypes in type I diabetes mellitus. [PDF]

, 1984
D Raum, Z Awdeh, E.J. Yunis, C A Alper, Kenneth H. Gabbay   +4 more
openalex   +1 more source

Haplotype‐resolved genome and pan‐genome graphs reveal the impacts of structural variation on functional genome and feather colors in chickens

iMetaOmics, EarlyView.
This study built a Wenchang chicken haplotype genome and integrated it with 29 others to create a chicken pangenome atlas. Analysis of 354 chickens revealed 185,205 structural variations (SVs), with one‐third derived from homology‐based and transposable elements.
Lihong Gu, Chen Peng, Anhong Chen, Kaiyu Chen, Xinli Zheng, Dongyou Yu, Zhengguang Wang, Lingzhao Fang, George E. Liu, Pengju Zhao   +9 more
wiley   +1 more source

Influence of SLA haplotype on ovulation rate and litter size in miniature pigs [PDF]

, 1988
Alan J. Conley, Young‐Chul Jung, Nimrod Schwartz, Carol M. Warner, M. F. Rothschild, Stephen P. Ford   +5 more
openalex   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, EarlyView.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source

The relationship between t and H-2 complexes in wild mice: I. The H-2 haplotypes of 20 t-bearing strains [PDF]

, 1982
Sabine Sturm, Felipe Figueroa, Jan Klein
openalex   +1 more source