Results 91 to 100 of about 19,297 (229)

Antibody developments for metal ions and their applications

Food and Agricultural Immunology, 2020
Metal ions are beneficial or toxic in part depending on their identity, valence state, and concentration. Antibodies against radioactive metal ions can be used in medical diagnosis and therapy, while antibodies against heavy metal ions are widely used in
Yulong Wang, Cunzheng Zhang, Fengquan Liu   +2 more
doaj   +1 more source

Severe Cutaneous Adverse Reactions Associated With Newer‐Generation Antiseizure Medications: A Real‐World Pharmacovigilance Study Based on FAERS and JADER

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
A cross‐database analysis of FAERS and JADER confirmed lamotrigine and zonisamide as the dominant SJS/TEN/DRESS risk drivers across both systems. After polytherapy adjustment, eslicarbazepine (DRESS, ROR 10.41) and levetiracetam emerged as reproducible novel signals warranting clinical attention. SJS/TEN onset concentrated within 4 weeks, whereas DRESS
Longfei You, Dong Zhang, Zhihua Cheng, Yinbao Qi, Ruobing Qian   +4 more
wiley   +1 more source

A focused antibody library for improved hapten recognition

, 2005
The topography of the antigen-binding site as well as the number and the positioning of the antigen contact residues are strongly correlated with the size of the antigen with which the antibody interacts.
Ohlin, Mats, Persson, Helena, Lantto, Johan   +2 more
core   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Molecular dynamics simulations of hapten binding to structural models of 2-phenyloxazolone antibodies

, 1992
Structural models of an anti-2-phenyloxazolone (Ox1) idiotype and its high-affinity variant NQ22/18.7 were constructed by computer-aided molecular modeling using known structures of highly homologous immunoglobulins as templates.
Teleman, Olle, Holm, Liisa, Laaksonen, Leif, Hoffren, Anna-Marja, Teeri, Tuula   +4 more
core   +1 more source

Patch Testing With a Brazilian Propolis Series

Contact Dermatitis, EarlyView.
Anton C. de Groot, Norbertus A. Ipenburg, Sylvie M. Franken, Thomas Rustemeyer   +3 more
wiley   +1 more source

Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201

Allergy, Volume 81, Issue 6, Page 2036-2046, June 2026.
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen, Heidi Heiniluoto, Janne Jänis, Kristiina Takkinen, Juha Rouvinen   +4 more
wiley   +1 more source

General scheme for addition of different linkers to Hapten 7.

, 2013
General scheme for addition of different linkers to Hapten 7.
Heather L. Davis (465261), Phil White (465256), James R. Merson (465260), Lyn H. Jones (465244), Alan D. Brown (465249), Michelle Benoit (465258), David C. Pryde (353590), Yvonne Wharton (465254), Jotham W. Coe (465250), Ningli Zhang (465257), David P. Gervais (465245), David C. Blakemore (465247), Rebecca Glen (465253), Matthew Badland (465251), Gavin J. Miller (465255), David M. Beal (465252), Michael J. McCluskie (465262), David R. Stead (465246), Matthew D. Selby (465248), Karen Robertson (465259)   +19 more
core   +1 more source

Clinical Factors Associated With Current Relevance in Allergic Contact Dermatitis: Development of Predictive Models Based on Data From the Spanish Contact Dermatitis Register (REIDAC)

Contact Dermatitis, Volume 94, Issue 6, Page 614-623, June 2026.
This study has shown a moderate performance of the regression model to predict current relevance (AUC = 0.679), although modelling performance has been better for specific allergens (e.g., nickel with an AUC = 0.770). Furthermore, it has identified key predictors, including female gender, specific involved sites (hands, neck, head, legs, feet), and ...
David Pesqué, Francisco Javier Ortiz de Frutos, Francisco Navarro‐Triviño, Tatiana Sanz‐Sánchez, Violeta Zaragoza‐Ninet, Susana Córdoba‐Guijarro, Javier Miquel‐Miquel, Juan Francisco Silvestre‐Salvador, Ricardo González‐Pérez, Inmaculada Ruiz‐González, Pedro Mercader‐García, Esther Serra‐Baldrich, José Manuel Carrascosa‐Carrillo, Fátima Tous‐Romero, Mercedes Rodríguez‐Serna, María Elena Gatica‐Ortega, Carmen Paredes‐Suárez, María Antonia Pastor‐Nieto, Pablo Chicharro, Marta Andreu, Araceli Sánchez‐Gilo, José Juan Pereyra‐Rodríguez, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua‐González, Fernando Gallardo, Ramon M. Pujol, Ignacio García‐Doval, Leopoldo Borrego, Miguel Ángel Descalzo, Ana M. Giménez‐Arnau   +31 more
wiley   +1 more source

Modification and expulsion of keratins by human epidermal keratinocytes upon hapten exposure in vitro.

, 2011
Allergic contact dermatitis is the most prevalent form of human immunotoxicity. It is caused by reactive low molecular weight chemicals, that is, haptens, coming in contact with the skin where hapten-peptide complexes are formed, activating the immune ...
Ericson, Marica B,, Ericson, Marica B, Charlotte A. Jonsson, Stenfeldt, Anna-Lena, Simonsson, Carl,, Anna-Lena Stenfeldt, Marica B. Ericson, Sofia I. Andersson, Bergström, Jörgen,, Jörgen Bergström, Broo, Kerstin S, Stenfeldt, Anna-Lena,, Jonsson, Charlotte A, Andersson, Sofia, Kerstin S. Broo, Andersson, Sofia,, Bauer, Brigitte, Bauer, Brigitte,, Simonsson, Carl, Carl Simonsson, Jonsson, Charlotte A,, Bergstr\uf6m, J\uf6rgen, Brigitte Bauer   +22 more
core   +1 more source