Results 81 to 90 of about 9,252,196 (204)

European Society of Contact Dermatitis Guideline for Diagnostic Patch Testing—Recommendations on Best Practice (Update 2026)

open access: yesContact Dermatitis, Volume 95, Issue 3, Page 237-275, September 2026.
ABSTRACT The present guideline updates the initial ESCD patch testing guideline, summarizing all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed‐type hypersensitivity skin and mucosal conditions. Sections with brief descriptions
Wolfgang Uter   +23 more
wiley   +1 more source

Design Education as a Catalyst for Change

open access: yes, 2018
Designers play a role in shaping our world, both literally and figuratively. Human lives are spent interacting with designed artefacts, systems, and processes.
Mulder, Ingrid   +9 more
core   +1 more source

Developmental Fates of Progenitor/Undifferentiated Cells With Histone Trimethylation Tags in the Stony Coral, Acropora tenuis

open access: yesDevelopment, Growth &Differentiation, Volume 68, Issue 7, September 2026.
In the stony coral, Acropora tenuis, embryos and larvae have progenitor/undifferentiated cells. Undifferentiated‐like cells differentiate into the pharyngeal stomodeum at an early larval stage, and nerve progenitors possess the dual potential to differentiate into nerve cells and vacuolated hyaline cells, depending on the oral‐aboral position ...
Kaz Kawamura   +2 more
wiley   +1 more source

Design and Synthesis of Haptens for Application to the Preparation of Chiral 1,4-Dihydropyridines.

open access: yesChemical and Pharmaceutical Bulletin, 1998
Lipase-catalyzed enzymatic hydrolysis of dimethyl esters of 1, 4-dihydropyridines to the monoester, which is an important intermediate for the synthesis of optically active 1, 4-dihydropyridines, does not proceed directly. This paper describes the design and synthesis of novel haptens having a phosphonate group containing the requisite oxyanionic ...
IKEDA, Kiyoshi   +3 more
openaire   +2 more sources

Protective and Pathogenic Antibodies to Citrullinated Antigens

open access: yesImmunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Outi Sareila   +5 more
wiley   +1 more source

Germinal Center Selection and Plasma Cell Differentiation

open access: yesImmunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Germinal centers (GCs) are specialized microenvironments in which B cells undergo affinity maturation through iterative cycles of somatic hypermutation, proliferation and selection, generating antibodies with improved antigen‐binding properties.
Adrien Sprumont, Oliver Bannard
wiley   +1 more source

Selective Targeting of the L858R Mutation (EGFR) in Non-Small Cell Lung Cancer: A Mechanism for Advancing Targeted Chemotherapy

open access: yesFrontiers in Oncology, 2017
Lung cancer remains one of today’s most deadly and intractable cancers. Non-small cell lung cancer (NSCLC) accounts for roughly 85% of lung cancers, with an extremely poor survival rate.
Rohan Arora, Venkat Krishnan
doaj   +1 more source

Plasma Cell Selection and Migration in the Establishment of Long‐Lived Antibody Responses

open access: yesImmunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT As B cells are activated and differentiate into plasma cells, they execute migration programs that allow them to traffic within secondary lymphoid tissues and reach the bone marrow, where they can mature as long‐lived plasma cells. Recent studies have revealed mechanisms underlying not only affinity‐driven but also isotype‐driven plasma cell ...
Wataru Ise   +2 more
wiley   +1 more source

Probing the Effects of Hapten Stability on Cocaine Vaccine Immunogenicity

open access: yes, 2016
Judicious hapten design has been shown to be of importance when trying to generate a viable vaccine against a drug of abuse. Hapten design has typically been predicated upon faithfully emulating the unique chemical architecture that each drug presents ...
Xiaoqing Cai (288275)   +6 more
core   +1 more source

Oral PHGG ameliorates atopic dermatitis‐like dermatitis with concurrent modulation of colonic IgA and cecal microbiota: implications for the gut–skin axis

open access: yesJournal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6380-6394, 30 August 2026.
Abstract BACKGROUND Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut–skin axis remains unexplored.
Derrick Kakooza   +6 more
wiley   +1 more source

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