Results 81 to 90 of about 8,472 (222)
Haptens with bridge at the 2-position have not yet been explored. Radioimmunoassays with antibodies directed against 2-alpha-alkyl bridged steroid haptens are expected to be highly specific due to greater topographical exposure and similarity in ...
DESAI, UR, TRIVEDI, GK
core +1 more source
Precise quantitative and highly sensitive detection of small molecules (haptens) is highly demanded in medicine, food quality control, in vitro diagnostics, criminalistics, environmental monitoring, etc.
Guteneva Natalia V. +4 more
doaj +1 more source
The relation between the in vitro immunogenicity of phosphatidylcholine liposomes containing 2,4-dinitrophenyl-6-Ar-aminocaproy]phosphatidylethanolamine (DNP-Cap-PE) as a hapten and the topographical distribution of the haptens on lipid membranes was ...
Keiichiro Hashimoto +4 more
core
Use of novel haptens in the production of antibodies for the detection of tryptamines
We synthesized haptens derived from tryptamine-based drugs and used them in the production of antibodies against various tryptamines.
Lucie Fojtíková +5 more
core +1 more source
Ability of non-animal methods for skin sensitisation to detect pre- and pro-haptens: Report and recommendations of an EURL ECVAM expert meeting [PDF]
Significant progress has been made in the development, validation and regulatory acceptance of in chemico and in vitro test methods for skin sensitisation.
DUMONT Coralie +10 more
core +1 more source
An analysis method using simple instrumentation was developed to investigate isothiazolinones in cosmetic and household products in patch test investigations. Analysis showed that concentrations of benzisothiazolinone can be several orders of magnitude higher than those of chloromethylisothiazolinone/methylisothiazolinone in products to which skin ...
Anne Farbrot +8 more
wiley +1 more source
The binding of divalent haptens to IgE-class antibodies leads predominantly to their oligomerization into open and closed dimers. Kinetics of the open dimer formation was investigated by fluorescence titrations of Fab fragments of monoclonal DNP-specific
Pecht, I. +2 more
core +1 more source
Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska +2 more
wiley +1 more source
T cell receptor (TCR) interaction with haptens: metal ions as non-classical haptens
Haptens are classified as low molecular chemicals with an intrinsic potential to covalently modify proteins, and many of them are strong inducers of contact hypersensitivity (CHS).
Guerreiro, N. +4 more
core
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho +3 more
wiley +1 more source

