Results 81 to 90 of about 8,472 (222)

NEW STEROID HAPTENS FOR RADIOIMMUNOASSAY - SYNTHESIS OF STEROIDS SUBSTITUTED WITH THIOETHER OR ESTER LINKAGES AT THE 2-ALPHA-POSITION

open access: yes, 1991
Haptens with bridge at the 2-position have not yet been explored. Radioimmunoassays with antibodies directed against 2-alpha-alkyl bridged steroid haptens are expected to be highly specific due to greater topographical exposure and similarity in ...
DESAI, UR, TRIVEDI, GK
core   +1 more source

Volumetric registration of magnetic nanoparticles for optimization of quantitative immunochromatographic assays for detection of small molecules

open access: yesEPJ Web of Conferences, 2018
Precise quantitative and highly sensitive detection of small molecules (haptens) is highly demanded in medicine, food quality control, in vitro diagnostics, criminalistics, environmental monitoring, etc.
Guteneva Natalia V.   +4 more
doaj   +1 more source

Immunogenicity of Liposomal Model Membranes Sensitized with Spin-Labeled Haptens and Topographical Distribution of Haptens on the Membranes1

open access: yes, 1982
The relation between the in vitro immunogenicity of phosphatidylcholine liposomes containing 2,4-dinitrophenyl-6-Ar-aminocaproy]phosphatidylethanolamine (DNP-Cap-PE) as a hapten and the topographical distribution of the haptens on lipid membranes was ...
Keiichiro Hashimoto   +4 more
core  

Use of novel haptens in the production of antibodies for the detection of tryptamines

open access: yes, 2018
We synthesized haptens derived from tryptamine-based drugs and used them in the production of antibodies against various tryptamines.
Lucie Fojtíková   +5 more
core   +1 more source

Ability of non-animal methods for skin sensitisation to detect pre- and pro-haptens: Report and recommendations of an EURL ECVAM expert meeting [PDF]

open access: yes, 2016
Significant progress has been made in the development, validation and regulatory acceptance of in chemico and in vitro test methods for skin sensitisation.
DUMONT Coralie   +10 more
core   +1 more source

Development of a Generic Analysis Method for Isothiazolinones in Consumer Products Prompted by Increased Sensitisation to Benzisothiazolinone

open access: yesContact Dermatitis, Volume 95, Issue 1, Page 33-42, July 2026.
An analysis method using simple instrumentation was developed to investigate isothiazolinones in cosmetic and household products in patch test investigations. Analysis showed that concentrations of benzisothiazolinone can be several orders of magnitude higher than those of chloromethylisothiazolinone/methylisothiazolinone in products to which skin ...
Anne Farbrot   +8 more
wiley   +1 more source

Dimerization kinetics of the IgE-class antibodies by divalent haptens. I. The Fab-hapten interactions

open access: yes, 1992
The binding of divalent haptens to IgE-class antibodies leads predominantly to their oligomerization into open and closed dimers. Kinetics of the open dimer formation was investigated by fluorescence titrations of Fab fragments of monoclonal DNP-specific
Pecht, I.   +2 more
core   +1 more source

Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming

open access: yesPlant Biotechnology Journal, Volume 24, Issue 7, Page 4619-4639, July 2026.
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska   +2 more
wiley   +1 more source

T cell receptor (TCR) interaction with haptens: metal ions as non-classical haptens

open access: yes, 2005
Haptens are classified as low molecular chemicals with an intrinsic potential to covalently modify proteins, and many of them are strong inducers of contact hypersensitivity (CHS).
Guerreiro, N.   +4 more
core  

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

open access: yesCancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho   +3 more
wiley   +1 more source

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