Results 91 to 100 of about 8,472 (222)

Severe Cutaneous Adverse Reactions Associated With Newer‐Generation Antiseizure Medications: A Real‐World Pharmacovigilance Study Based on FAERS and JADER

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
A cross‐database analysis of FAERS and JADER confirmed lamotrigine and zonisamide as the dominant SJS/TEN/DRESS risk drivers across both systems. After polytherapy adjustment, eslicarbazepine (DRESS, ROR 10.41) and levetiracetam emerged as reproducible novel signals warranting clinical attention. SJS/TEN onset concentrated within 4 weeks, whereas DRESS
Longfei You, Dong Zhang, Zhihua Cheng, Yinbao Qi, Ruobing Qian   +4 more
wiley   +1 more source

Recognition of b-ketoalcohol-derived Haptens by Tailor-made antibodies.

, 2001
Antibodies from mice immunized towards three' different conjugates do not recognize the b-ketoalc. for which they have been elaborated. They however recognize the haptens, which bear the side chain linking them to the carrier proteins.
Letesson, Jean-Jacques, Billen, Denis, Krief, Alain, Swinnen, Dominique   +3 more
core  

A rapid method for monitoring DNA labelling reactions with haptens

, 1990
A rapid and simple method for evaluating the efficiency of DNA labelling reactions with haptens is described. The method, called the Flow-Through Hapten-DNA Assay (FT-HDA), relies on binding of anti-hapten antibodies/alkaline phosphatase conjugates to ...
A. Corti, Tripputi P, CORTI , ANGELO, G. Cassani, Cassani G., P. Tripputi   +5 more
core   +1 more source

Imunopatologia da dermatite de contato alérgica Immunopathology of allergic contact dermatitis

Anais Brasileiros de Dermatologia, 2011
A dermatite de contato alérgica é consequência de uma reação imune mediada por células T contra químicos de baixo peso molecular, denominados haptenos. É uma condição frequente que ocorre em todas as raças e faixas etárias e afeta a qualidade de vida de ...
Luis Eduardo Agner Machado Martins, Vitor Manoel Silva dos Reis   +1 more
doaj   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.

, 2009
BACKGROUND: Mutations in the human filaggrin gene (FLG) are associated with atopic dermatitis (AD) and are presumed to provoke a barrier abnormality.
Gunathilake, R, Hatano, Y, Mauro, T M, Silva, K A, Man, M Q, Hupe, M, Scharschmidt, T C, Sundberg, J P, Crumrine, D, et, al   +9 more
core   +2 more sources

Patch Testing With a Brazilian Propolis Series

Contact Dermatitis, EarlyView.
Anton C. de Groot, Norbertus A. Ipenburg, Sylvie M. Franken, Thomas Rustemeyer   +3 more
wiley   +1 more source

Recognition of β-ketoalcohol-derived haptens by tailor-made antibodies

, 2001
Antibodies steamed from mice immunized towards three different conjugates do not recognize the β-ketoalcohol for which they have been elaborated. They however recognize the haptens, which bear the side chain linking them to the carrier proteins.
Billen, D., Letesson, J.-J.; id_orcid, Krief, A., Swinnen, D.   +3 more
core  

Clinical Factors Associated With Current Relevance in Allergic Contact Dermatitis: Development of Predictive Models Based on Data From the Spanish Contact Dermatitis Register (REIDAC)

Contact Dermatitis, Volume 94, Issue 6, Page 614-623, June 2026.
This study has shown a moderate performance of the regression model to predict current relevance (AUC = 0.679), although modelling performance has been better for specific allergens (e.g., nickel with an AUC = 0.770). Furthermore, it has identified key predictors, including female gender, specific involved sites (hands, neck, head, legs, feet), and ...
David Pesqué, Francisco Javier Ortiz de Frutos, Francisco Navarro‐Triviño, Tatiana Sanz‐Sánchez, Violeta Zaragoza‐Ninet, Susana Córdoba‐Guijarro, Javier Miquel‐Miquel, Juan Francisco Silvestre‐Salvador, Ricardo González‐Pérez, Inmaculada Ruiz‐González, Pedro Mercader‐García, Esther Serra‐Baldrich, José Manuel Carrascosa‐Carrillo, Fátima Tous‐Romero, Mercedes Rodríguez‐Serna, María Elena Gatica‐Ortega, Carmen Paredes‐Suárez, María Antonia Pastor‐Nieto, Pablo Chicharro, Marta Andreu, Araceli Sánchez‐Gilo, José Juan Pereyra‐Rodríguez, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua‐González, Fernando Gallardo, Ramon M. Pujol, Ignacio García‐Doval, Leopoldo Borrego, Miguel Ángel Descalzo, Ana M. Giménez‐Arnau   +31 more
wiley   +1 more source

Hapten-carrier interactions and their role in the production of monoclonal antibodies against hydrophobic haptens

, 1996
The coupling of haptens to carrier proteins is required for the generation of antihapten antibody response, To date, different polypeptides (such as gelatin, albumin, and keyhole limpet hemocyanin) have been used to increase the immune response against ...
Marini, S, Bannister, JV, Fasciglione, GF, Giardina, B, FASCIGLIONE, GIOVANNI, MARINI, STEFANO, Giardina, B.   +6 more
core