Results 61 to 70 of about 8,472 (222)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber +8 more
wiley +1 more source
Assessment of Pre- and Pro-haptens Using Nonanimal Test Methods for Skin Sensitization
, 2016 Because of ethical and regulatory reasons, several nonanimal test methods to assess the skin sensitization potential of chemicals have been developed and validated. In contrast to in vivo methods, they lack or provide limited metabolic capacity.
Daniel Urbisch (2630335) +15 more
core +1 more source
, 2021 We previously found that the immune response to haptens is positively correlated with molecular hydrophobicity. The antibodies used in immunoassays for capsaicinoids (CPCs) in waste oil suffer from low affinity and loose recognition to structural ...
Hui Jiang +21 more
core +1 more source
Contact Dermatitis, EarlyView.This study mimics clinical patch testing for the diagnosis of allergic contact dermatitis, by application of patch test preparations of fragrance terpenes to ex vivo human skin samples. The study investigates the penetration of linalool hydroperoxide and limonene hydroperoxide in skin, alongside an analysis of the lipid‐modifying effects of the patch ...
Aoife Clancy +3 more
wiley +1 more source
, 1992 Interactions between a monoclonal, DNP-specific IgE molecules (hybridoma A2) and divalent DNP-haptens in solution cause aggregation of the former predominantly into closed rings of two IgE and two divalent haptens (Schweitzer-Stenner, R., A.
Pecht, I. +2 more
core +1 more source
, 2008 Citation: 'hapten' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.H02738 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +2 more sources
Contact Dermatitis, EarlyView.Finn Chamber AQUA (FCA) detects significantly higher contact allergy prevalences to linalool hydroperoxides (7.0% vs. 5.1% FC) and limonene hydroperoxides (7.8% vs. 3.0% FC, 3.8% IQ) than Finn Chamber (FC) or IQ Ultra (IQ) in 629 dermatitis patients; chamber choice is therefore crucial for diagnostics.
Henrik Luu +4 more
wiley +1 more source
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
Pharmaceutics, 2020 Allergic contact dermatitis is a common occupational disease that manifests as a cell-mediated hypersensitivity reaction following skin exposure to small reactive chemicals termed haptens.
Ana Isabel Sebastião +5 more
doaj +1 more source
Contact Dermatitis, EarlyView.ABSTRACT The present guideline updates the initial ESCD patch testing guideline, summarizing all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed‐type hypersensitivity skin and mucosal conditions. Sections with brief descriptions
Wolfgang Uter +23 more
wiley +1 more source
, 2000 Two 2-aminophosphonate haptens derived from methyl α-d-glucopyranoside were synthesized to mimic the transition-state of a transesterification reaction between methyl α-d-glucopyranoside and 4-nitrophenylester of tert-BOC-β-alanine.
Yli-Kauhaluoma, Jari +3 more
core +1 more source