Results 51 to 60 of about 9,284 (223)
Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper
Allergy, EarlyView.ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres +19 more
wiley +1 more source
Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice. [PDF]
PLoS ONE, 2013 Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) which reduce nicotine entering the brain, and hence the associated reward.
David C Pryde +19 more
doaj +1 more source
Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization
Frontiers in Pharmacology, 2021 Human skins are exposed to nanomaterials in everyday life from various sources such as nanomaterial-containing cosmetics, air pollutions, and industrial nanomaterials. Nanomaterials comprising metal haptens raises concerns about the skin sensitization to
Sung-Hyun Kim +8 more
doaj +1 more source
Synthesis of Haptens 1, 2, 3, 4, 6 and 7.
, 2013 Synthesis of Haptens 1, 2, 3, 4, 6 and 7.
Heather L. Davis (465261) +19 more
core +1 more source
Pre‐Seasonal Treatment With Recombinant Carrier‐Based Birch Vaccine Improves Birch Pollen Allergy
Allergy, EarlyView.We conducted a two stage SCIT trial with GNR‐127 containing a recombinant fusion protein consisting of Bet v 1 and Mal d 1‐derived peptides fused to PreS from HBV. Stage 1 identified two safe maximum tolerated doses (40 μg and 80 μg). In the following Stage 2, five preseasonal injections were well tolerated, induced dose‐dependent allergen‐specific IgG,
Musa R. Khaitov +43 more
wiley +1 more source
Contact Dermatitis, EarlyView.Finn Chamber AQUA (FCA) detects significantly higher contact allergy prevalences to linalool hydroperoxides (7.0% vs. 5.1% FC) and limonene hydroperoxides (7.8% vs. 3.0% FC, 3.8% IQ) than Finn Chamber (FC) or IQ Ultra (IQ) in 629 dermatitis patients; chamber choice is therefore crucial for diagnostics.
Henrik Luu +4 more
wiley +1 more source
Heliyon, 2023 Ustilaginoidins are a class of bis-naphtho-γ-pyrone mycotoxins to threaten humans, animals and environment. Ustilaginoidins are produced by Villosiclava virens, the rice false smut pathogen.
Weixuan Wang +9 more
doaj +1 more source
, 2022 [EN] We present the first synthesis of beta-lactam-derived haptens, leveraging the principles of diversity-oriented synthesis to discover compounds for drug allergy in vitro testing.
Peña-Mendizábal, Edurne +6 more
core +1 more source
Contact Dermatitis, EarlyView.This study identified multiple areas for improvement in the regulatory risk assessment process. Conclusions based on predictive sensitization data should be made with caution, read‐across data from known sensitizers should be utilized, and epidemiological and patient threshold data should be prioritized in decision‐making.
Mathias Krogh Pedersen +7 more
wiley +1 more source
Assessment of Pre- and Pro-haptens Using Nonanimal Test Methods for Skin Sensitization
, 2016 Because of ethical and regulatory reasons, several nonanimal test methods to assess the skin sensitization potential of chemicals have been developed and validated. In contrast to in vivo methods, they lack or provide limited metabolic capacity.
Daniel Urbisch (2630335) +15 more
core +1 more source