Results 91 to 100 of about 1,956 (188)

Suppression of Harmaline Tremor by Activation of an Extrasynaptic GABAA Receptor: Implications for Essential Tremor

open access: yesTremor and Other Hyperkinetic Movements, 2018
Background: Metabolic imaging has revealed excessive cerebellar activity in essential tremor patients. Golgi cells control cerebellar activity by releasing gamma-aminobutyric acid (GABA) onto synaptic and extrasynaptic receptors on cerebellar granule ...
Adrian Handforth   +3 more
doaj   +1 more source

A Fully Validated LC-MS Quantitation Method for Psychoactive Compounds Found in Native South American Plant Species

open access: yesPsychoactives
Psychoactive drugs are compounds that alter the function of the central nervous system, resulting in changes in perception, mood, cognition, and behavior.
Jonathan Tran   +4 more
doaj   +1 more source

Implications of functional anatomy on information processing in the deep cerebellar nuclei

open access: yesFrontiers in Cellular Neuroscience, 2009
The cerebellum has been implicated as a major player in producing temporal acuity. Theories of cerebellar timing typically emphasize the role of the cerebellar cortex while overlooking the role of the deep cerebellar nuclei (DCN) that provide the sole ...
Yuval Baumel   +3 more
doaj   +1 more source

The Olivary Hypothesis of Essential Tremor: Time to Lay this Model to Rest?

open access: yesTremor and Other Hyperkinetic Movements, 2017
Background: Although essential tremor (ET) is the most common tremor disorder, its pathogenesis is not fully understood. The traditional model of ET, proposed in the early 1970s, posited that the inferior olivary nucleus (ION) was the prime generator of ...
Elan D. Louis, Abhishek Lenka
doaj   +1 more source

Inhibition of Na+-Ca2+ exchange mechanism in cardiac sarcolemmal vesicles by harmaline [PDF]

open access: yes, 1987
1. Harmaline was found to inhibit the Na+-Ca2+ exchange mechanism present in cardiac sarcolemmal vesicles. 2. The inhibition was dose-dependent and was observed in the range 10(-5) M-10(-2) M harmaline. 3.
Reeves, J P, Suleiman, M S
core  

The Effects of Intra-Amygdala Injection of Nicotine and Harmaline on Anxiey- Related Behavior in Adult Male Rat [PDF]

open access: yes, 2023
B-carboline alkaloids such as harmaline and nicotine are naturally present in the human food chain.Plants which contain B-caroline have anxiety and hallucinogenic effects.
R. Poozesh , Gh. Vaezi , F. Faizy ,
core   +1 more source

ePoster

open access: yes
European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines

open access: yesNature Communications, 2019
Little is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in ...
Toshiki Nagakubo   +4 more
doaj   +1 more source

Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies

open access: yesBrazilian Journal of Psychiatry, 2016
Objective: To conduct a systematic literature review of animal and human studies reporting anxiolytic or antidepressive effects of ayahuasca or some of its isolated alkaloids (dimethyltryptamine, harmine, tetrahydroharmine, and harmaline).
Rafael G. dos Santos   +3 more
doaj   +1 more source

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

open access: yesPharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia   +18 more
doaj   +1 more source

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