Results 91 to 100 of about 49,566 (218)

Characterization of Hepatitis B Virus Transcripts in Chronically HBV-Infected Chimpanzees and Patients Treated with ARC-520 siRNA Demonstrates Transcriptional Silencing of cccDNA

Viruses
Full-length hepatitis B virus (HBV) transcripts of chimpanzees and patients treated with multidose (MD) HBV siRNA ARC-520 and entecavir (ETV) were characterized by single-molecule real-time (SMRT) sequencing, identifying multiple types of transcripts ...
Christine I. Wooddell, Dean Sanders, Zhao Xu, Lung-Yi Mak, Thomas Schluep, Wai-Kay Seto, Bruce D. Given, Man-Fung Yuen   +7 more
doaj   +1 more source

Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.

PLoS ONE, 2015
To describe the Hepatitis B e antigen(HBeAg) seroconversion related mutation profiles of the basal core promoter(BCP)/precore regions in e antigen seroconverted child patients, a cohort of 245 child patients with CHB and a control patients group of 92 ...
Yong Huang, Haijun Deng, Xuefeng Shan, Xuyang Gong, Xiaosong Li, Zen Tu, Quanxin Long, Ailong Huang   +7 more
doaj   +1 more source

Hepatitis B e antigen induces the expansion of monocytic myeloid-derived suppressor cells to dampen T-cell function in chronic hepatitis B virus infection. [PDF]

PLoS Pathogens, 2019
Chronic hepatitis B virus (HBV) infection is associated with functionally impaired virus-specific T cell responses. Although the myeloid-derived suppressor cells (MDSCs) are known to play a critical role in impairing antiviral T cell responses, viral ...
Feifei Yang, Xueping Yu, Chenliang Zhou, Richeng Mao, Mengqi Zhu, Haoxiang Zhu, Zhenxuan Ma, Bidisha Mitra, Gan Zhao, Yuxian Huang, Haitao Guo, Bin Wang, Jiming Zhang   +12 more
doaj   +1 more source

The Roles of Alix and VPS4A in Autophagy and Endosomal Pathways and Their Relation to HBV Replication

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Alix and VPS4A function in HBV biogenesis and degradation in the context of the endosomal and autophagic pathways. Alix and VPS4A orchestrate HBV secretion and degradation via endosomal and autophagic pathways. Under normal conditions, ESCRT ensures efficient virion budding and MVB formation.
Jia Li, Thekla Kemper, Shuping Tong, Xueyue Wang, Yong Lin, Mengji Lu   +5 more
wiley   +1 more source

Lack of association between early on-treatment HBeAg seroclearance and development of hepatocellular carcinoma or decompensated cirrhosis

JHEP Reports
Background & Aims: The association between hepatitis B envelope antigen (HBeAg) seroclearance during long-term nucleos(t)ide analogue (NA) treatment and the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) remains ...
Hyunjae Shin, Won-Mook Choi, Seung Up Kim, Yunmi Ko, Youngsu Park, Jeayeon Park, Moon Haeng Hur, Min Kyung Park, Yun Bin Lee, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee, Fabien Zoulim   +12 more
doaj   +1 more source

Pediatric liver diseases: current challenges and future perspectives [PDF]

, 2015
Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma.
Alisi, Anna, Alterio, Arianna, Della Corte, Claudia, Mosca, Antonella, Nobili, Valerio, Vania, Andrea   +5 more
core   +1 more source

Different interventional criteria for chronic hepatitis B pregnant women with HBeAg(+) or HBeAg(-)

Medicine, 2018
The seroprevalence of hepatitis B virus (HBV) and its impact on pregnancy outcomes of women from Shaanxi Province (China) was assessed. Risk factors for mother-to-child transmission (MTCT) were evaluated based on HBV-related seroprevalence data.
Tianyan Chen, Jing Wang, H. Qiu, Qiang Yu, T. Yan, C. Qi, F. Cao, Z. Tian, D. Guo, N. Yao, Yuan Yang, Yingli He, Yingren Zhao, Jinfeng Liu   +13 more
semanticscholar   +1 more source

Preventing Mother to Child Transmission of Human Immunodeficiency Virus: 20‐Year Trends in Management and Clinical Practice in a French Hospital – A Retrospective Observational Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Since the discovery of human immunodeficiency virus (HIV) mother to child transmission (MTCT), its prevention has been a priority. Guideline adherence has drastically reduced MTCT, virtually inexistent today in high‐income countries.
Boris Dmitrenko, Emmanuelle Vintejoux, Florent Fuchs, Joana Pissarra, Lionel Moulis, Philippe Van de Perre   +5 more
wiley   +1 more source

Relation of hepatitis B core antigen expression with histological activity, serum HBeAg, and HBV DNA levels

Indian Journal of Pathology and Microbiology, 2011
Background: Hepatitis B virus (HBV) is a potentially life-threatening liver infection which may progress to liver failure and cirrhosis. Intrahepatic expression patterns of viral antigens detected by immunohistochemistry may have prognostic implications ...
Aysegul Sari, Yelda Dere, Betul Pakoz, Aylin Calli, Belkis Unal, Mine Tunakan   +5 more
doaj   +1 more source

Central obesity and advanced liver stiffness in Hepatitis B: Result from golestan hepatitis B cohort study [PDF]

, 2015
Background: Chronic infection with the hepatitis B virus and obesity may both contribute synergistically to liver disease, although relatively few studies have investigated this hypothesis.
Besharat, S., Freedman, N.D., Malekzadeh, R., Merat, S., Mohamadkhani, A., Poustchi, H., Roshandel, G.   +6 more
core