Results 91 to 100 of about 42,544 (264)

Entecavir and peginterferon alfa-2a in adults with HBeAg-positive immune tolerant chronic hepatitis B virus infection

Hepatology, 2018
Monotherapy with interferon or nucleoside analog is generally not recommended during the immune‐tolerant (IT) phase of chronic hepatitis B virus (HBV) infection.
J. Feld, N. Terrault, Hsing-Hua S. Lin, S. Belle, R. Chung, N. Tsai, M. Khalili, R. Perrillo, S. Cooper, M. Ghany, H. Janssen, A. Lok   +11 more
semanticscholar   +1 more source

Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi

BMC Infectious Diseases, 2021
Background The World Health Organization (WHO) has targeted a reduction in viral hepatitis-related mortality by 65% and incidence by 90% by 2030, necessitating enhanced hepatitis B treatment and prevention programmes in low- and middle-income countries ...
Alexander J. Stockdale, Niza M. Silungwe, Isaac Thom Shawa, Benno Kreuels, Melita A. Gordon, Anna Maria Geretti   +5 more
doaj   +1 more source

HBsAg and HBeAg in the prediction of a clinical response to peginterferon α-2b therapy in Chinese HBeAg-positive patients [PDF]

Virology Journal, 2016
This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course of pegylated interferon alfa-2b therapy at 1.5 mcg/kg.HBsAg, HBeAg, and hepatitis B virus (HBV) DNA levels were measured at baseline and weeks ...
Yang, Song, Xing, Huichun, Wang, Yuming, Hou, Jinlin, Luo, Duande, Xie, Qing, Ning, Qin, Ren, Hong, Ding, Huiguo, Sheng, Jifang, Wei, Lai, Chen, Shijun, Fan, Xiaoling, Huang, Wenxiang, Pan, Chen, Gao, Zhiliang, Zhang, Jiming, Zhou, Boping, Chen, Guofeng, Wan, Mobin, Tang, Hong, Wang, Guiqiang, Yang, Yuxiu, Xu, Dongping, Dong, Peiling, Wang, Qixin, Wang, Jue, Bognar, Fernando A., Xu, Daozhen, Cheng, Jun   +29 more
openaire   +2 more sources

The Malaysian Society of Gastroenterology and Hepatology Consensus Statements on Prevention and Early Detection of Hepatocellular Carcinoma in Malaysia

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer‐related deaths in Malaysia. Early detection increases the likelihood of curative treatment and improves survival. This consensus document aims to provide evidence‐based, locally relevant recommendations for the prevention and early detection of HCC.
Su Yin Lau, Victoria Sinq‐Ling Kok, Soek‐Siam Tan, Syuhada Dan Adnan, Wei‐Lin Ng, Ban‐Hong Ang, Nur Yazmin Yaacob, Yeong Yeh Lee, Senamjit Kaur, Rosmawati Mohamed, Ping‐Foo Wong, Lee‐Ling Lim, Mohana Letchumanan, Shireene Ratna Vethakkan, Nurain Mohd Noor, Siow‐Foon Tan, Tiong‐Lim Low, Lee‐Boon Kiew, Wah‐Kheong Chan   +18 more
wiley   +1 more source

TUBB1 promoter methylation is a promising biomarker for predicting HBeAg seroconversion in chronic hepatitis B

Microbiology Spectrum
The identification of predictive indices for hepatitis B e antigen seroconversion (HBeAg SC) in patients with chronic hepatitis B (CHB) remains a challenge.
Tong Zhao, Yuna Tang, Yu Sun, Jihui Li, Yuchen Fan, Chao Cui, Shuai Gao, Kai Wang   +7 more
doaj   +1 more source

Clinical application of estimating hepatitis B virus quasispecies complexity by massive sequencing: correlation between natural evolution and on-treatment evolution.

PLoS ONE, 2014
AimTo evaluate HBV quasispecies (QA) complexity in the preCore/Core regions in relation to HBeAg status, and explore QA changes under natural evolution and nucleoside analogue (NUC) treatment.MethodsUltra-deep pyrosequencing of HBV preCore/Core regions ...
Maria Homs, Andrea Caballero, Josep Gregori, David Tabernero, Josep Quer, Leonardo Nieto, Rafael Esteban, Maria Buti, Francisco Rodriguez-Frias   +8 more
doaj   +1 more source

Seroepidemiology of hepatitis B virus in Addis Ababa Ethiopia: transmission patterns and vaccine control [PDF]

, 2003
A community-based seroepidemiological survey of Addis Ababa, Ethiopia was conducted in 1994 to inform on the transmission dynamics and control of hepatitis B virus (HBV) infection.
Cutts, FT, Dejene, A, Cutts, Felicity, Nokes, D. James, Dejene, A., Messele, T., Enquselassie, F., Abebe, A, Nokes, DJ, Messele, T, Abebe, A., Enquselassie, F   +11 more
core   +1 more source

Gaps in the Cascade of Care Contribute to Poor Liver Cancer Outcomes Among People Living With Hepatitis B: A Multicenter Observational Cohort Study

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Chronic hepatitis B virus (HBV) remains a major cause of hepatocellular carcinoma (HCC) in Australia, despite the availability of effective, subsidized antiviral therapy. We aimed to describe the clinical characteristics, HBV care cascade, and outcomes among people with HBV‐related HCC in Victoria, Australia.
Dina Moussa, Joan Ericka Flores, Michael Macisaac, Jack Wallace, Joseph Doyle, Marno Ryan, Thai Hong, Brett Knowles, Adrian Fox, Ashu Jhamb, Tom Sutherland, Stuart Roberts, William Kemp, Ammar Majeed, Marie Sinclair, Rohit Sawhney, Stephen Bloom, Amanda Nicoll, Zina Valaydon, Gauri Mishra, Sid Sood, Diana Lewis, A. Thompson, J. Howell   +23 more
wiley   +1 more source

Characterization of Hepatitis B Virus Transcripts in Chronically HBV-Infected Chimpanzees and Patients Treated with ARC-520 siRNA Demonstrates Transcriptional Silencing of cccDNA

Viruses
Full-length hepatitis B virus (HBV) transcripts of chimpanzees and patients treated with multidose (MD) HBV siRNA ARC-520 and entecavir (ETV) were characterized by single-molecule real-time (SMRT) sequencing, identifying multiple types of transcripts ...
Christine I. Wooddell, Dean Sanders, Zhao Xu, Lung-Yi Mak, Thomas Schluep, Wai-Kay Seto, Bruce D. Given, Man-Fung Yuen   +7 more
doaj   +1 more source

Hepatitis B virus infection with high HBsAg and undetectable DNA levels in untreated blood donors: Viral mechanisms and transfusion safety implications

Transfusion, EarlyView.
Abstract Background Blood donor screening occasionally identifies individuals with high HBV surface antigen (HBsAg) levels despite undetectable or extremely low HBV DNA. Molecular basis and transfusion risk of this discordant profile remain unclear. Study Design and Methods Seventy‐five blood donors with HBsAg >100 IU/mL and undetectable or very low ...
Maelenn Païline Delcourt, Marion Vermeulen, Aneta Kopacz, Manuela Miletic, Andrew Saville, Christoph Niederhauser, Jean‐Michel Pawlotsky, Syria Laperche, Daniel Candotti   +8 more
wiley   +1 more source