Results 11 to 20 of about 15,946 (160)

Indeterminate Phase/Grey Zone of Chronic Hepatitis B: Clinical Features, Outcomes and Molecular Insights. [PDF]

Liver Int
ABSTRACT Chronic hepatitis B virus (HBV) infection remains a global public health challenge, with a high risk of complications such as cirrhosis, hepatocellular carcinoma (HCC) and death. As outlined in current international society guidelines, antiviral therapies are aimed at preventing progression of liver disease to life‐threatening complications ...
Franzè MS, Pollicino T, Pawlotsky JM, Leroy V, Raimondo G, Amaddeo G.   +5 more
europepmc   +2 more sources

Prevalence and Risk Factors of Elevated Alanine Aminotransferase (ALT) in 2382 Treatment-naïve HBV/HDV Co-Infected Patients. [PDF]

Liver Int
ABSTRACT Background Chronic hepatitis D (CHD) causes severe chronic hepatitis. Knowledge is limited about factors correlating with ALT in treatment‐naïve patients with CHD. This study analysed the pattern and determinants of ALT elevation in a large cohort of patients with CHD, including young adults, compared to propensity score‐matched (PSM) patients
Kamal H, Jargalsaikhan G, Enkhtaivan S, Lindahl K, Hagström H, Bruce D, Ingre M, Dashtserenx B, Lkhagva-Ochir O, Ulziibadrakh T, Bungert A, Wedemeyer H, Dashdorj NB, Aleman S.   +13 more
europepmc   +2 more sources

Virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) in patients with type B hepatitis

Hepatology, 1987
In order to establish the virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) during hepatitis B virus infection, HBsAg, HBeAg and hepatitis B virus DNA in serum and HBeAg in liver were determined quantitatively in relation to the detection of HBeAg subtypes in agar gel diffusion.
A, Kanno, H, Ohori, K, Matsuda, H, Nakayama, Y, Miyazaki, M, Ishii, H, Suzuki, M, Ohtsuki, Y, Goto   +8 more
  +7 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Tenofovir Alafenamide Fumarate Reduces Virological Replication in HBeAg-Negative Patients With Normal Alanine Aminotransferase: A 48-Week Randomised Controlled Trial. [PDF]

J Viral Hepat
ABSTRACT The optimal strategy for chronic hepatitis B virus (HBV) infected patients with negative hepatitis B e‐antigen (HBeAg) and normal alanine aminotransferase (ALT) remains uncertain. This study aimed to evaluate the safety and efficacy of tenofovir alafenamide fumarate (TAF) treatment in this patient population.
Luo Q, Xu W, Zhang Y, Li X, Lai J, Li J, Zheng X, Deng H, Chen L, Zhu X, Xie C, Peng L.   +11 more
europepmc   +2 more sources

HBV RNA Predicts the Risk of Off‐Treatment Relapse in Chronic Hepatitis B Patients With NAs Therapy: A Systematic Review and Meta‐Analysis [PDF]

J Viral Hepat
ABSTRACT Since there are currently few antiviral drugs that can effectively reduce hepatitis B surface antigen levels, the recurrence rate remains high in patients with chronic hepatitis B (CHB) after discontinuing nucleoside analogues (NAs) treatment.
Wang D, Wang J, Jiang S, Zhou A, Jin M, Zhang H, Yang S, Fan S, Hu A.   +8 more
europepmc   +2 more sources

Mathematical investigation of HBeAg seroclearance

Mathematical Biosciences and Engineering, 2019
Spontaneous or drug-induced loss of hepatitis B e antigen is considered a beneficial event in the disease progression of chronic hepatitis B virus infections. Mathematical models of within-host interactions are proposed; which provide insight into hepatitis B e antibody formation, its influence on hepatitis B e antigen seroclearance, and reversion of ...
Sarah Kadelka, Stanca M Ciupe
openaire   +4 more sources

Predictive significance of serum pgRNA in HBeAg clearance for chronic hepatitis B patients with low HBeAg level after pegylated interferon treatment

Di-san junyi daxue xuebao, 2022
Objective To evaluate the predictive efficacy of serum pregenomic RNA (pgRNA) level in HBeAg clearance for chronic hepatitis B (CHB) patients treated with polyethylene glycol interferon alfa (PEG-IFN-α).
LIU Zhongwei, LIU Ming, GONG Hongmei, WU Yi, MAO Qing   +4 more
doaj   +1 more source

Is hepatitis B antigen in cord blood an immunotolerogen playing a critical role in the pathogenesis of chronic hepatitis B?

Human Vaccines & Immunotherapeutics, 2019
Recently, we showed that infants with or without fetal hepatitis B e antigen (HBeAg) exposure had comparable antibody response to hepatitis B vaccination and proposed that fetal HBeAg exposure appears to not induce immunotolerance to HBV.
Hongyu Huang, Mingzhe Ning, Jingli Liu, Jie Chen, Jing Feng, Yimin Dai, Yali Hu, Yi-Hua Zhou   +7 more
doaj   +1 more source

CHRONIC HEPATITIS B VIRUS INFECTION IN PREGNANCY: STRATEGIES OF ANTIVIRAL THERAPY

Alʹmanah Kliničeskoj Mediciny, 2016
Treatment of chronic hepatitis B during pregnancy is an extremely complicated issue. Despite  implementation of immune prophylaxis, a significant proportion of babies born by mothers with  high viral load are infected by hepatitis B virus.
P. O. Bogomolov, M. V. Matsievich, K. Yu. Kokina, N. V. Voronkova, O. S. Kuz'mina, A. O. Bueverov   +5 more
doaj   +1 more source