Results 21 to 30 of about 42,544 (264)

Understanding the antiviral effects of RNAi-based therapy in HBeAg-positive chronic hepatitis B infection

Scientific Reports, 2021
The RNA interference (RNAi) drug ARC-520 was shown to be effective in reducing serum hepatitis B virus (HBV) DNA, hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) in HBeAg-positive patients treated with a single dose of ARC-520 and ...
S. Kadelka, H. Dahari, Stanca M. Ciupe
semanticscholar   +1 more source

Serological detection of hepatitis B virus e antigen and TNF-α in a dialysis patient

Medical Journal of Babylon, 2023
Background: The hepatitis B virus (HBV) is responsible for all forms of hepatitis (occult HBV infection [OBI]) endangering the health of the public. The growth, division, and activity of immune cells are governed by chemical mediators called cytokines ...
Aneeda Khraibet Abed, Zaytoon A Alkhafaji, Ali Jaber Abood   +2 more
doaj   +1 more source

Relationships between HBeAg status of patients with chronic hepatitis B and changes in serum TNF-α, viral load and severity of morphological changes in the liver according to non-invasive tests

Patologìâ, 2021
Aim – to investigate the relationship between HBeAg status of patients with chronic hepatitis B and the content of TNF-α in the serum, the level of viral load and the severity of morphological changes in the liver according to non-invasive tests ...
A. B. Khelemendyk, O. V. Riabokon, Yu. Yu. Riabokon, K. V. Kalashnyk   +3 more
doaj   +1 more source

Accuracy of HBeAg to identify pregnant women at risk of transmitting hepatitis B virus to their neonates: a systematic review and meta-analysis.

Lancet. Infectious Diseases (Print), 2020
BACKGROUND Prevention of mother-to-child transmission (MTCT) of hepatitis B virus (HBV) involves neonatal immunoprophylaxis, with a birth dose of hepatitis B vaccine and immune globulin, and provision of peripartum antiviral prophylaxis in highly ...
P. Boucheron, Ying Lu, Kyoko Yoshida, T. Zhao, A. Funk, F. Lunel-Fabiani, A. Guingané, E. Tuaillon, Judith van Holten, R. Chou, M. Bulterys, Y. Shimakawa   +11 more
semanticscholar   +1 more source

Antiviral Treatment and One-Year Follow-Up of Chronic Hepatitis B Patients in Bandung: An Observational Study

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2022
Background: Hepatitis B Virus (HBV) is a health problem that has chronically infected 257 million globally. Appropriate therapy is immensely needed to prevent disease progression to cirrhosis and hepatocellular carcinoma (HCC).
Eka Surya Nugraha, Stefanie Hadi Supriami, Nur Atik, Nenny Agustanti, Yudi Wahyudi, Dolvy Girawan, M Begawan Bestari, Siti Aminah Abdurachman   +7 more
doaj   +1 more source

Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients

Journal of Hepatology, 2020
Background & Aims Factors associated with a successful outcome upon nucleos(t)ide analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients have yet to be clarified.
M. García-López, S. Lens, Laura J. Pallett, B. Testoni, S. Rodríguez‐Tajes, Z. Mariño, C. Bartrés, E. García-Pras, T. Leonel, Elena Perpiñán, J. Lozano, F. Rodríguez-Frías, G. Koutsoudakis, F. Zoulim, M. Maini, X. Forns, S. Pérez‐del‐Pulgar   +16 more
semanticscholar   +1 more source

Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity.

Journal of Hepatology, 2020
BACKGROUND HBeAg seroconversion during the natural history of chronic hepatitis B (CHB) is associated with a strong drop in serum HBV DNA levels and a reduction of intrahepatic covalently closed circular DNA (cccDNA) content.
A. Suslov, Marie-Anne Meier, S. Ketterer, Xueya Wang, S. Wieland, M. Heim   +5 more
semanticscholar   +1 more source

Seroprevalence of Hepatitis B Virus in Pregnant Women at a Tertiary Care Hospital of Eastern India [PDF]

National Journal of Laboratory Medicine, 2016
Introduction: Hepatitis B virus is a DNA virus causing hepatitis in humans. It is thought to be responsible for chronic liver diseases in 75% of cases. Besides other routes, vertical transmission from mother to child is an important one.
Archana Sinha, Minu Sharan, S.K. Shahi
doaj   +1 more source

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B

Gut, 2020
Objective The involvement of HBV DNA integration in promoting hepatocarcinogenesis and the extent to which the intrahepatic HBV reservoir modulates liver disease progression remains poorly understood.
V. Svicher, R. Salpini, L. Piermatteo, L. Carioti, A. Battisti, L. Colagrossi, R. Scutari, M. Surdo, V. Cacciafesta, A. Nuccitelli, N. Hansi, Francesca Ceccherini Silberstein, C. Perno, U. Gill, P. Kennedy   +14 more
semanticscholar   +1 more source

Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study

Hepatology International, 2020
Background As an important anti-HBV drug, pegylated interferon α (PegIFNα) offers promising clinical efficacy, but biomarkers that accurately forecast treatment responses are yet to be elucidated.
Min Zhang, Guangdi Li, J. Shang, C. Pan, M. Zhang, Zhibiao Yin, Q. Xie, Yanzhong Peng, Q. Mao, Xin-qiang Xiao, Yongfang Jiang, Kaizhong Luo, Yun Xu, Hai Ding, Wenzhou Fan, Vidaurre Diego, M. Pourkarim, E. De Clercq, Guiqiang Wang, G. Gong   +19 more
semanticscholar   +1 more source