HBV‐RNA Co‐amplification May Influence HBV DNA Viral Load Determination [PDF]
Hepatology Communications, 2020 Despite effective hepatitis B virus (HBV)‐DNA suppression, HBV RNA can circulate in patients receiving nucleoside/nucleotide analogues (NAs). Current assays quantify HBV DNA by either real‐time polymerase chain reaction (PCR), which uses DNA polymerase ...
Benjamin Maasoumy +12 more
doaj +2 more sources
Zhongguo shuxue zazhi, 2022 Objective To investigate the serological and molecular characteristics of HBsAg+ /HBV DNA non-reactive (NR) infections. Methods Samples tested as HBsAg+ and HBV DNA NR were confirmed by individual NAT repeat testing, viral particle concentration by PEG ...
Chunxiang LI +8 more
doaj +2 more sources
The Infection Efficiency and Replication Ability of Circularized HBV DNA Optimized the Linear HBV DNA in Vitro and in Vivo [PDF]
International Journal of Molecular Sciences, 2015 Studies on molecular mechanisms of the persist infection of hepatitis B virus have been hampered by a lack of a robust animal model. We successfully established a simple, versatile, and reproducible HBV persist infection model in vitro and in vivo with the circularized HBV DNA. The cells and mice were transfected or injected with circularized HBV DNA
Li, Xiaosong +7 more
openaire +3 more sources
The E3 Ubiquitin Ligase TRIM21 Promotes HBV DNA Polymerase Degradation
Viruses, 2020 The tripartite motif (TRIM) protein family is an E3 ubiquitin ligase family. Recent reports have indicated that some TRIM proteins have antiviral functions, especially against retroviruses.
Ting Mu +4 more
doaj +3 more sources
Association between HBV DNA levels and bone mineral density in antiviral-naive chronic hepatitis B patients [PDF]
Frontiers in EndocrinologyObjectivesRecent studies have shown that patients with chronic hepatitis B (CHB) have an increased prevalence of osteoporosis. However, the direct relationship between hepatitis B virus (HBV) DNA (representing the viral replication level) and bone ...
Xinyu Zhou +5 more
doaj +2 more sources
HBV DNA polymerase regulates tumor cell glycogen to enhance the malignancy of HCC cells [PDF]
Hepatology CommunicationsBackground:. The essential function of HBV DNA polymerase (HBV-DNA-Pol) is to initiate viral replication by reverse transcription; however, the role of HBV-DNA-Pol in HBV-associated HCC has not been clarified.
Xiaoqing Zhao +3 more
doaj +2 more sources
Association between high HBV-DNA viral load and liver metastasis risk in patients with nasopharyngeal carcinoma [PDF]
Virus ResearchA total of 976 patients with nasopharyngeal carcinoma (NPC) confirmed by pathology in Xiangya Cancer Hospital of Central South University from May 2017 to December 2022 were recruited for the study.
Xiaofan Wang +3 more
doaj +2 more sources
Coexisting patterns and significance of serum HBV RNA and HBV DNA in patients with treatment-naïve chronic hepatitis B virus infection [PDF]
Frontiers in MedicineAimThe study aimed to explore the coexisting patterns and assess the significance of serum hepatitis B virus (HBV) RNA and traditional virological biomarkers in patients with antiviral treatment-naïve chronic hepatitis B virus (HBV) infection ...
Kun-yan Hao +4 more
doaj +2 more sources
Lower HBV DNA level is associated with more severe liver fibrosis in HBeAg-positive chronic hepatitis B with normal alanine transaminase [PDF]
Virology JournalBackground The association of hepatitis B virus (HBV) DNA levels and liver fibrosis in chronic hepatitis B (CHB) patients with immune-tolerant phase remains unclear.
Jian Wang +18 more
doaj +2 more sources
HBV DNA polymerase upregulates the transcription of PD-L1 and suppresses T cell activity in hepatocellular carcinoma [PDF]
Journal of Translational MedicineBackground In HBV-associated HCC, T cells often exhibit a state of functional exhaustion, which prevents the immune response from rejecting the tumor and allows HCC to progress.
Yan Jia +6 more
doaj +2 more sources