Results 31 to 40 of about 1,221,411 (264)

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV

BMC Infectious Diseases, 2022
Backgrounds: Hepatitis B virus (HBV) biomarkers reflect the status of HBV infection; however, their role in patients with chronic hepatitis B and C (HBV/HCV) coinfection remains unknown.
Chih-Wei Tseng, Wen-Chun Liu, Chi-Yi Chen, Ting-Tsung Chang, Kuo-Chih Tseng   +4 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Persistently Elevated HBV Viral-Host Junction DNA in Urine as a Biomarker for Hepatocellular Carcinoma Minimum Residual Disease and Recurrence: A Pilot Study

Diagnostics, 2023
Hepatitis B virus (HBV)-host junction sequences (HBV-JSs) has been detected in the urine of patients with HBV infection. This study evaluated HBV-JSs as a marker of minimum residual disease (MRD) and tumor recurrence after treatment in HBV-hepatocellular
Selena Y. Lin, Dina Halegoua-DeMarzio, Peter Block, Yu-Lan Kao, Jesse Civan, Fwu-Shan Shieh, Wei Song, Hie-Won Hann, Ying-Hsiu Su   +8 more
doaj   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

3D landscape of Hepatitis B virus interactions with human chromatins

Cell Discovery, 2020
Hepatitis B viral (HBV) DNAs, including covalently closed circular DNA (cccDNA) and integrated HBV DNA forms, are considered to be primary contributors to the development and progression of HBV-associated liver diseases.
Bo Yang, Boyuan Li, Liyang Jia, Yongpeng Jiang, Xin Wang, Shaodong Jiang, Shunda Du, Xiong Ji, Pengyuan Yang   +8 more
doaj   +1 more source

Hepatocyte Endoplasmic Reticulum Stress Inhibits Hepatitis B Virus Secretion and Delays Intracellular Hepatitis B Virus Clearance After Entecavir Treatment

Frontiers in Medicine, 2021
Background: The aim of this study was to explore the effects of endoplasmic reticulum (ER) stress on hepatitis B virus (HBV) replication and the antiviral effect of entecavir (ETV).Methods: Thapsigargin (TG) and stearic acid (SA) were used to induce ER ...
Huan Chen, Maoyuan Mu, Qichuan Liu, Han Hu, Caiyun Tian, Guoyuan Zhang, Ying Li, Fangwan Yang, Shide Lin   +8 more
doaj   +1 more source

Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia. [PDF]

, 2008
BACKGROUND: Little is known about changes in hepatitis B viral load (HBV DNA) in relation to age in Africa. The aim of this study is to determine the natural course of HBV chronic infection, particularly in relation to sequential changes in serum HBV DNA
Jeffries, David, Kaye, Steve, Hilton C. Whittle (7946705), David Jeffries, Maimuna E Mendy, Samuel J McConkey, Steve Kaye, Samuel McConkey (7896113), Marianne AB Sande van der (7946780), Kaye Steve, Mendy, Maimuna E, Maimuna E. Mendy (7946657), Hall, Andrew J, Mendy Maimuna E, Andrew J Hall, Crozier, Sarah, McConkey, Samuel J, Sarah Crozier (46005), Sande van der, Marianne AB, Steve Kaye (46006), Whittle, Hilton C, Andrew J. Hall (78002), Whittle Hilton C, Sande van der Marianne AB, Hilton C Whittle, Marianne AB Sande van der, David Jeffries (46007), Sarah Crozier, Jeffries David, McConkey Samuel J, Hall Andrew J, Crozier Sarah   +31 more
core   +1 more source

Suppression of HBV by Tenofovir in HBV/HIV coinfected patients : a systematic review and meta-analysis [PDF]

, 2013
Background: Hepatitis B coinfection is common in HIV-positive individuals and as antiretroviral therapy has made death due to AIDS less common, hepatitis has become increasingly important. Several drugs are available to treat hepatitis B. The most potent
Thomas Reiberger, Richard Gilson, Noriyoshi Kuzushita, Firouze Bani-Sadr (432319), Nüesch, R, David Dunn (37023), Marina Núñez, Lionel Tan, Stephan Christoph, Peters, M, Tan, L (Lionel), Pillay, Deenan, Huw Price, de Vries-Sluijs, T, Reto Nüesch, Dunn, David, Peters, Marion, Kuzushita, N, Kuzushita Noriyoshi, Firouze Bani-Sadr, Bani-Sadr, Firouze, Mauss Stefan, Reiberger, Thomas, Stefan Mauss, Gilson, Richard, Mauß, Stefan, Mamta K Jain, Theodora de Vries-Sluijs, Tan, Lionel, Gilson, R, Price, H, Gilson Richard, Huw Price (300124), Jain Mamta K., Peters Marion, Reiberger Thomas, Thomas Reiberger (143056), Nüesch Reto, Price, Huw, Richard Gilson (125405), David Dunn, Reto Nüesch (432324), Nüesch, Reto, Marina Núñez (432323), Pillay Deenan, Deenan Pillay (7888), Price Huw, Tan, L, Tan Lionel, Dunn David, Kuzushita, Noriyoshi, Christoph Stephan (283267), Stephan, C, Christoph Stephan, Pillay, D, Núñez Marina, Núñez, M, Stefan Mauss (143062), Bani-Sadr, F, Peters, M (Marjolein), Jain, MK, Bani-Sadr Firouze, de Vries-Sluijs Theodora, Stephan, Christoph, Theodora de Vries-Sluijs (432320), Lionel Tan (124548), Dunn, D, Marion Peters, Reiberger, T, Mamta K. Jain, Noriyoshi Kuzushita (432322), Mamta K. Jain (432321), Marion Peters (403490), Mauss, S, Jain, Mamta K., Núñez, Marina, Deenan Pillay, Nueesch, R, Vries-Sluijs, Theodora de   +78 more
core   +1 more source