Results 61 to 70 of about 1,221,411 (264)

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease

, 2012
Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to
Chopra, A., Gordon, A, Scott Bowden, Pfafferott, K, Desmond, P.V., Ian R. James, Revill, P.A., Chopra, A, Mallal, SA, Silvana Gaudieri, Anna Ayres, Lewin, S.R., Thompson, AJ, Desmond, C.P., Jennifer Audsley, James, IR, Locarnini, SA, Stephen A. Locarnini, Sharon R. Lewin, James, I.R., Locarnini, S.A., Chivers, S., Christopher P. Desmond, Desmond, PV, Thompson, A.J., Stuart K. Roberts, Audsley, J, Revill, PA, Lau, GK, Gaudieri, S, Gaudieri, S., Audsley, J., Day, C, Caroline Day, Ayres, A, Day, C., Paul V. Desmond, Pfafferott, K., Gordon, A., Roberts, SK, Peter A. Revill, Alexander J. Thompson, Ayres, A., Desmond, CP, Sarah Chivers, Katja Pfafferott, Bowden, S., George K. Lau, Simon A. Mallal, Lewinb, SR, Lau, G.K., Roberts, S. K., Abha Chopra, Bowden, S, Mallal, S.A., Adam Gordon, Chivers, S   +56 more
core   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

ADAR1 Inhibits HBV DNA Replication via Regulating miR-122-5p in Palmitic Acid Treated HepG2.2.15 Cells

, 2022
Hongli Yang,1,* Fajuan Rui,2,* Rui Li,3,* Shengxia Yin,4 Qi Xue,1 Xinyu Hu,5 Yayun Xu,5 Chao Wu,4 Junping Shi,6 Jie Li2,4 1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji’nan ...
Yang H, Li J, Rui F, Yin S, Xue Q, Hu X, Wu C, Li R, Shi J, Xu Y   +9 more
core  

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

HBV-CARE Networking Day Report.docx

, 2023
A systematic report of the HBV-CARE (Clinicians, Advocates and Researchers Exchange) group networking day held at The Francis Crick Institute.
Marion Delphin (11921561), Elizabeth Waddilove (16453620), Philippa Matthews (10958922)   +2 more
core   +1 more source

Development of Pentaplex Reverse Transcription Droplet Digital PCR Assay for Simultaneous Detection and Absolute Quantification of HIV‐1, HIV‐2, HCV, and HBV With Internal Control

ELECTROPHORESIS, EarlyView.
Development of Pentaplex reverse transcription droplet digital PCR assay for simultaneous detection and absolute quantification of HIV‐1, HIV‐2, HCV, and HBV with internal control. The channel‐resolved multiplex strategy enables high sensitivity, robust quantification, and scalable digital PCR workflows across platforms.
Soo Yeon Lim, Un Na Koh, Ah Leum Kim, Yebin Kim, Ga Eun Kim, Si‐Keun Lim   +5 more
wiley   +1 more source

Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians. [PDF]

, 2010
BACKGROUND: The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area.
Jobarteh Modou, Mendy Maimuna, Cotten Matt, Cotten, M, Alabi, A, Tedder, Richard, Sarge-Njie Ramu, Peterson, Ingrid, Whittle, H, Jaye, A, Peterson Ingrid, Richard Tedder, Rowland-Jones, Sarah, Malfroy Marine, Peterson, K, Maimuna Mendy, Jobarteh, Modou, Cotten, Matt, Tedder Richard, Malfroy, M, Peterson, I, Hilton Whittle, Matt Cotten, Sarge-Njie, Ramu, Sarah Rowland-Jones, Ingrid Peterson, Hall, A, Peterson, Kevin, Peterson Kevin, Jaye Assan, Jaye, Assan, Tedder, R, Mendy, Maimuna, Whittle Hilton, Modou Jobarteh, Hall, Andrew, Hall Andrew, Jeng Adam, Alabi, Abraham, Ramu Sarge-Njie, Malfroy, Marine, Mendy, M, Alabi Abraham, Assan Jaye, Whittle, Hilton, Jeng, A, Adam Jeng, Rowland-Jones Sarah, Jobarteh, M, Andrew Hall, Jeng, Adam, Kevin Peterson, Marine Malfroy, Abraham Alabi, Sarge-Njie, R, Rowland-Jones, S   +55 more
core   +1 more source

Prospective comparison of Abbott RealTime HBV DNA and Versant HBV DNA 3.0 assays for hepatitis B DNA quantitation: Impact on HBV genotype monitoring

, 2008
International audienceThe quantitation of human hepatitis B virus (HBV) in the serum of infected patients is recommended to characterize the course of chronic HBV infection.
Le Pendeven, Catherine, Didier Grange, Jean, Jais, Jean, Philippe, Beby-Defaux, Agnès, Soussan, Patrick, Osada, Catherine, Pilloux, Marilyse, Pol, Jonathan, Zatla, Fadila, Nicolas, Jean,, Rabut, Elodie, Jais, Jean,, Assami, Hichem, Nicolas, Jean, Claude, Kremsdorf, Dina   +14 more
core   +1 more source