Results 171 to 180 of about 305,562 (334)

AEG-1 targeting for inhibiting inflammation: potential anti-HCC strategy

, 2019
Saranya Chidambaranathan Reghupaty, Rachel G. Mendoza, Devanand Sarkar   +2 more
openalex   +1 more source

In Situ Assembly of Transformable Monopeptide on Activated Neutrophils Attenuates NETs‐Induced Hepatocellular Carcinoma Metastasis by Disrupting NE Nuclear Translocation

Advanced Science, EarlyView.
Activated neutrophils release extracellular traps (NETs) that promote tumor metastasis. FTP‐NPs are develpoed, a peptidic nanomaterial that binds NE on neutrophil membranes, forming NE‐fibril clusters that deactivate NE and prevent NETs formation. This strategy reduces metastasis and enhances the anti‐tumor immune response by targeting NE subcellular ...
Yichi Chen, Yijun Wang, Haitao Shang, Jiayue Qiu, Ruotian Zhang, Yuxiang Xiong, Tong Wang, Fengyi Wang, Anbang Wu, Xin Lin, Bolin Wu, Chen Huang, Wen Cheng, Lu Zhang   +13 more
wiley   +1 more source

Fatty liver disease is not associated with increased mortality in the elderly: A prospective cohort study

Hepatology, EarlyView., 2022
Graphical abstract summarizing the study design, main results and key findings Abstract Background and Aims Fatty liver disease (FLD) has been associated with excess mortality. Screening for hepatic steatosis (HS) in patients with metabolic dysfunction is therefore recommended by several guidelines, despite a paucity of evidence on the clinical ...
Laurens A. van Kleef, Milan J. Sonneveld, Maryam Kavousi, M. Arfan Ikram, Robert A. de Man, Robert J. de Knegt   +5 more
wiley   +1 more source

Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC [PDF]

Przemysław Glaza, Roman Pluta, Krzysztofa Odrzywol, Marta Klejnot, Maria Sagan, Sylvain Cottens, Donald Coppen, Paweł Dobrzański, Tomáš Drmota, Joanna Lis-Grześniak, Agata Pawlik, Joanna Majkut, Martyna Mianowska, Paulina Rozborska, Marta Jarmuszkiewicz, Katarzyna Kaczanowska, Aleksandra Adamska, Toshimitsu Takagi, Anna Sawicka, Anna Serwotka-Suszczak, Olga Makowska, Daria Gajewska, Kinga Jurczak, Kinga Leszkowicz, Michał Mankiewicz, Kamil Przytulski, Janusz Wiśniewski, Anna Szlachcic, Michał J. Walczak   +28 more
openalex   +1 more source

Verbesserte Wirksamkeit der FGFR Blockade durch mTOR Inhibition im HCC Modell [PDF]

, 2016
T Scheller
openalex   +1 more source

Sarcopenia Imperils Postoperative Long-Term Survival in HCC Patients with Metabolic Dysfunction-Associated Fatty Liver Disease: A Propensity Score Matching Analysis

, 2023
Qingyan Kong, Mengshi Yi, Fei Teng, Hang Li, Zheyu Chen   +4 more
openalex   +2 more sources

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS

Hepatology, EarlyView., 2022
The river diagram demonstrates that after transjugular intrahepatic portosystemic shunt insertion (TIPS) the majority of patients without ascites and 50% of the patients with ascites detectable at ultrasound, show the best response in the long term follow‐up.
Alexander Queck, Louise Schwierz, Wenyi Gu, Philip G. Ferstl, Christian Jansen, Frank E. Uschner, Michael Praktiknjo, Johannes Chang, Maximilian J. Brol, Filippo Schepis, Manuela Merli, Christian P. Strassburg, Jennifer Lehmann, Carsten Meyer, Jonel Trebicka   +14 more
wiley   +1 more source

Survival Benefit of Sequential Curative Treatment for TACE Suitable BCLC Stage B HCC Patients [PDF]

, 2023
Yuanjie Ding, Te‐Sheng Chang, Chien‐Heng Shen, Liang-Mou Kuo, Sheng-Lung Hsu, Yi‐Hsing Chen, Hui‐Ling Huang, Sheng‐Nan Lu   +7 more
openalex   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source