Results 211 to 220 of about 305,562 (334)

Adipocyte-derived FABP4 promotes metabolism-associated steatotic liver-induced hepatocellular carcinoma by driving ITGB1-mediated β-catenin activation. [PDF]

J Clin Invest
Leung CON, Gurung S, Chung KPS, Leung RWH, Lei MML, Chan MSM, Muliawan GK, Khan SA, Wu XQ, Yu J, Zhu HL, Lu YY, Ma S, Wu X, Hoo RLC, Lee TKW.   +15 more
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Diagnostic and prognostic performance of urinary neutrophil gelatinase‐associated lipocalin in patients with cirrhosis and acute kidney injury

Hepatology, EarlyView., 2022
Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino, Salvatore Piano, Matteo Stenico, Marta Tonon, Alessandra Brocca, Valeria Calvino, Simone Incicco, Nicola Zeni, Roberta Gagliardi, Chiara Cosma, Martina Zaninotto, Patrizia Burra, Umberto Cillo, Daniela Basso, Paolo Angeli   +14 more
wiley   +1 more source

Global 5mC and 5hmC levels in sixteen pairs of HCC and non-HCC samples and two HCC cell lines investigated by UPLC-MS/MS

, 2014
Fei Gao, Yudong Xia
openalex   +1 more source

Identification of HCC-Related Genes Based on Differential Partial Correlation Network

, 2021
Yuyao Gao, Xiao Chang, Jie Xia, Shaoyan Sun, Zengchao Mu, Xiaoping Liu   +5 more
openalex   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Oxide-hybridized carbon as a catalyst support for efficient anion exchange membrane water electrolysis. [PDF]

Nat Commun
Park JS, Lim HK, Hu C, Lee E, Jeon HS, Ryu J, Oh S, Lee TK, Park S, Cho HK, Yu SH, Ahn D, Lee YM, Kim MG, Yoo SJ.   +14 more
europepmc   +1 more source

Integrating Machine Learning and Spatial Transcriptomics Uncovers Shared Immunomodulatory Deubiquitinases in MAFLD and HCC [PDF]

Yuxi Han, Hongze Li, Xia Wang, Junyi Ma, Jiaqi Zhang, Yiling Li   +5 more
openalex   +1 more source

Toward Customization of Pickering Emulsion Nanocarriers for Personalized Delivery of Therapeutics in Cancer Treatments: A Review

Advanced NanoBiomed Research, EarlyView.
Pickering emulsion‐based nanocarriers are emerging as a disruptive innovation in oncology. Their unique structural and functional attributes have now positioned these systems at the forefront of next‐generation smart delivery platforms, capable of improving therapeutic precision, efficacy, and safety.
Nutan Shukla, Aayushi Chanderiya, Ratnesh Das, Supriya Vyas, Elizaveta Mukhanova, Alexander Soldatov, Samuel Adeloju   +6 more
wiley   +1 more source