Results 211 to 220 of about 277,119 (298)

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, EarlyView.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source

Incubating Ideas: A Typology of Design Thinking Academic Centers in American Higher Education

New Directions for Higher Education, EarlyView.
ABSTRACT Twenty years after the founding of the Hasso–Plattner Institute of Design (the d.School) at Stanford University, a wide range of academic centers and institutes have been established to prioritize innovation, creativity, and design thinking. This qualitative study presents a typology of these centers across the United States, drawing on “About
Margaret T. Konkel
wiley   +1 more source

Targeting MED8 enhances sorafenib sensitivity in hepatocellular carcinoma by disrupting epithelial-mesenchymal transition mechanisms. [PDF]

J Enzyme Inhib Med Chem
Li M, You X, Yuan T, He J, Xu Z, Liang S, Mao L, Jin A, Zhou X, Yi B, Li J, Tu Q.   +11 more
europepmc   +1 more source

Nasopharyngeal Endoscopic Resection Extended to the Internal Carotid Artery (Type 4): Technical Notes, Indications, and Outcomes

Head &Neck, EarlyView.
ABSTRACT Background Endoscopic surgical approaches for nasopharyngeal malignancies, including recurrent nasopharyngeal carcinoma (rNPC) and nasopharyngeal salivary gland tumors (NSGT), have seen significant development over the last decades. Our groups have expanded the classification of nasopharyngeal endoscopic resections (NER) from type 1 to 3 to ...
Francesco Boaria, Alessandro Vinciguerra, Stefano Taboni, Martina Conti, Paola Costantino, Vittorio Rampinelli, Marco Valentini, Francesca Gennarini, Benjamin Verillaud, Elisabetta Zanoletti, Davide Mattavelli, Alberto Schreiber, Mario Turri‐Zanoni, Alberto Daniele Arosio, Piergiorgio Gaudioso, Paolo Battaglia, Maurizio Bignami, Paolo Castelnuovo, Philippe Herman, Piero Nicolai, Marco Ferrari   +20 more
wiley   +1 more source

CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis and survival. While epidermal growth factor receptor (EGFR) is a known driver of HNSCC, EGFR inhibitors show limited efficacy as monotherapies, suggesting that effective combination therapies are needed.
Jiayu Wang, Megan L. Ludwig, Aditi Kulkarni, Andrew C. Birkeland, Nicole L. Michmerhuizen, Elizabeth Gensterblum‐Miller, Jingyi Zhai, Hui Jiang, Paul Swiecicki, Marisa Buchakjian, Molly Heft Neal, Steven B. Chinn, Matthew E. Spector, J. Chad Brenner   +13 more
wiley   +1 more source

The interplay between hepatitis B virus and antitumor drugs in the treatment of hepatocellular carcinoma. [PDF]

Clin Exp Med
Ma T, Zhao F, Yao L, Mao C, Tian Y, Ma Y, Kong F, Liu R.   +7 more
europepmc   +1 more source

Severity of microvascular invasion does matter in hepatocellular carcinoma prognosis: Editorial on “Classification of microvascular invasion of hepatocellular carcinoma: correlation with prognosis and magnetic resonance imaging” [PDF]

Clinical and Molecular Hepatology
Abdelrahman M Attia, Hasmik Adetyan, Ju Dong Yang   +2 more
doaj   +1 more source

Serum tyrosine level is an independent factor for hepatocellular carcinoma development and mortality in patients with chronic liver disease. [PDF]

Sci Rep
Oi M, Miwa T, Utakata Y, Aiba M, Unome S, Hanai T, Shiraki M, Katsumura N, Kawashima Y, Shimizu M.   +9 more
europepmc   +1 more source

IL27RA promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating TGFβR1. [PDF]

Sci Rep
Zhang Y, Wu Y, Zhang Q, Xiong J, Xiao B, Zuo S.   +5 more
europepmc   +1 more source

Alternative splicing immune signature for detecting HBV-related hepatocellular carcinoma in peripheral blood mononuclear cells. [PDF]

Biochem Biophys Rep
Daniels NJ, Hershberger CE, Rotroff DM.
europepmc   +1 more source