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Human Cytomegalovirus (HCMV) Replication Dynamics in HCMV‐Naive and ‐Experienced Immunocompromised Hosts [PDF]
The Journal of Infectious Diseases, 2002 Human cytomegalovirus (HCMV) can infect both HCMV-naive and -experienced transplant patients. In this study, the growth rate of HCMV in HCMV-naive hosts (1.82 units/day; 95% confidence interval [CI], 1.44-2.56 units/day) was shown to be significantly faster than the growth rate of virus in HCMV-experienced hosts undergoing recurrent infection (0.61 ...
Emery, VC +3 more
openaire +6 more sources
HCMV Antivirals and Strategies to Target the Latent Reservoir [PDF]
Viruses, 2021 Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people, primary infection is generally asymptomatic, and the virus can go on to establish lifelong latency in cells of the myeloid lineage.
Marianne R Perera, M. Wills, J. Sinclair
semanticscholar +5 more sources
A Systemic Receptor Network Triggered by Human cytomegalovirus Entry [PDF]
Advances in Virology Volume 2011 (2011), Article ID 262080, 11
pages, 2010 Virus entry is a multistep process that triggers a variety of cellular pathways interconnecting into a complex network, yet the molecular complexity of this network remains largely unsolved. Here, by employing systems biology approach, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic ...
Li, Hong, Ren, Li, Wang, Anyou
arxiv +6 more sources
HCMV latency: what regulates the regulators? [PDF]
Medical Microbiology and Immunology, 2019 Human cytomegalovirus (HCMV) latency and reactivation is regulated by the chromatin structure at the major immediate early promoter (MIEP) within myeloid cells.
Elizabeth G. Elder, J. Sinclair
semanticscholar +4 more sources
HCMV Infection and Apoptosis: How Do Monocytes Survive HCMV Infection? [PDF]
Viruses, 2018 Human cytomegalovirus (HCMV) infection of peripheral blood monocytes plays a key role in the hematogenous dissemination of the virus to multiple organ systems following primary infection or reactivation of latent virus in the bone marrow.
Donna Collins-McMillen +6 more
semanticscholar +5 more sources
HCMV Envelope Glycoprotein Diversity Demystified [PDF]
Frontiers in Microbiology, 2019 Human cytomegalovirus (HCMV) is the leading viral cause of congenital birth defects and is responsible for morbidity and mortality in immunosuppressed individuals.
Mathilde Foglierini +2 more
semanticscholar +5 more sources
US28: HCMV’s Swiss Army Knife [PDF]
Viruses, 2018 US28 is one of four G protein coupled receptors (GPCRs) encoded by human cytomegalovirus (HCMV). The US28 protein (pUS28) is a potent signaling molecule that alters a variety of cellular pathways that ultimately alter the host cell environment.
B. Krishna, W. Miller, C. O’Connor
semanticscholar +5 more sources
Challenging the Conventional Interpretation of HCMV Seronegativity [PDF]
Microorganisms, 2021 The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva so infection events are likely to be common. Indeed it is hard to imagine a life without exposure to HCMV.
Ashley Irish +4 more
openaire +6 more sources
Insight for Immunotherapy of HCMV Infection [PDF]
International Journal of Biological Sciences, 2021 Human cytomegalovirus (HCMV), a ubiquitous in humans, has a high prevalence rate. Young people are susceptible to HCMV infection in developing countries, while older individuals are more susceptible in developed countries. Most patients have no obvious symptoms from the primary infection.
Xinmiao Long +5 more
openaire +2 more sources
Human Cytomegalovirus Encoded miR-US25-1-5p Attenuates CD147/EMMPRIN-Mediated Early Antiviral Response. [PDF]
, 2017 Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection.
Chen, Huizi +6 more
core +12 more sources