Virus-Like Particles and Nanoparticles for Vaccine Development against HCMV
Viruses, 2019 Human cytomegalovirus (HCMV) infects more than 70% of the human population worldwide. HCMV is responsible for high morbidity and mortality in immunocompromised patients and remains the leading viral cause of congenital birth defects. Despite considerable
Michela Perotti, Laurent Perez
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PLoS Pathogens, 2015 Human Cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and in fetuses following congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are required for HCMV entry in ...
Claudio Ciferri +12 more
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Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients
Journal of Translational Medicine, 2017 Background Oral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of various diseases, but the clinical ...
Meng Ding +7 more
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Early Postnatal Infection With Human Cytomegalovirus Has Long‐Term Consequences on Brain Structure of Former Preterm Born Children [PDF]
Brain and BehaviorPurpose Congenital infection with human Cytomegalovirus (hCMV) is a common cause of severe neurodevelopmental disability, while postnatal infection of a term‐born infant will usually not lead to an adverse neurodevelopmental outcome.
Meike Müller +6 more
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Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Claudio Ciferri +12 more
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Human Cytomegalovirus (HCMV)-Specific CD4 + T Cells Are Polyfunctional and Can Respond to HCMV-Infected Dendritic Cells In Vitro [PDF]
Journal of Virology, 2017 Sarah Jackson +4 more
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Frontiers in Cellular and Infection Microbiology, 2023 Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a well-studied herpesvirus, has been implicated in malignancies derived from breast, colorectal muscle, brain, and other cancers.
Chuan Yu +5 more
semanticscholar +1 more source
EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells
PLoS Pathogens, 2023 Human cytomegalovirus (HCMV) infection is associated with human glioblastoma, the most common and aggressive primary brain tumor, but the underlying infection mechanism has not been fully demonstrated.
Xiao-Dong Dong +13 more
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Structural basis for HCMV Pentamer receptor recognition and antibody neutralization
Science Advances, 2022 Human cytomegalovirus (HCMV) represents the viral leading cause of congenital birth defects and uses the gH/gL/UL128-130-131A complex (Pentamer) to enter different cell types, including epithelial and endothelial cells.
M. Kschonsak +15 more
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Oncogenic and Stemness Signatures of the High-Risk HCMV Strains in Breast Cancer Progression
Cancers, 2022 Simple Summary Lately, human cytomegalovirus (HCMV) has been progressively implicated in carcinogenesis alongside its oncomodulatory impact. CMV-Transformed Human mammary epithelial cells (CTH) phenotype might be defined by giant cell cycling, whereby ...
Ranim El Baba +4 more
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