Results 21 to 30 of about 44,631 (298)

CARs—A New Perspective to HCMV Treatment [PDF]

Viruses, 2021
Human cytomegalovirus (HCMV), by primary infection or reactivation, represents a great risk for immune-suppressed or compromised patients. In immunocompetent humans, the immune system suppresses the spread of HCMV during an infection, resulting in a mostly asymptomatic or mild course of the disease, whereas in immune suppressed patients, the ...
Christopher Bednar, Armin Ensser
openaire   +5 more sources

Is HCMV a tumor promoter? [PDF]

Virus Research, 2011
Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes persistent infection in humans and can cause severe disease in fetuses and immunocompromised individuals. Although HCMV is not currently causally implicated in human cancer, emerging evidence suggests that HCMV infection and expression may be specifically associated with human malignancies ...
Liliana Soroceanu, Charles Cobbs, Charles Cobbs   +2 more
openaire   +3 more sources

Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes [PDF]

Virology Journal, 2020
Abstract Background Human cytomegalovirus (HCMV) causes asymptomatic infections, but also causes congenital infections when women were infected with HCMV during pregnancy, and life-threatening diseases in immunocompromised patients. To better understand the mechanism of the neutralization activity against HCMV, the association of HCMV NT antibody ...
Souichi Yamada, Takuya Inagaki, Takuya Inagaki, Tomoki Yoshikawa, Hikaru Fujii, Hikaru Fujii, Masashi Mizuguchi, Phu Hoang Anh Nguyen, Phu Hoang Anh Nguyen, Shuetsu Fukushi, Akira Oka, Masayuki Saijo, Masayuki Saijo, Shizuko Harada, Miho Shibamura, Miho Shibamura   +15 more
openaire   +4 more sources

A New Next-Generation Sequencing Approach in Human Cytomegalovirus for the Identification of Antiviral Resistance Mutations and Genotypic Classification. [PDF]

J Med Virol
ABSTRACT This study introduces a new procedure for antiviral resistance analysis and genetic classification of human cytomegalovirus (HCMV) using next‐generation sequencing (NGS) adapted to existing methodologies, aiming for more targets due to the recent use of new antivirals. It expands the classical investigation of mutations in UL54 and UL97 genes,
Arnedo-Muñoz M, Prats-Méndez I, Gónzalez-Sánchez A, Martín MC, Rando-Segura A, Arcos IL, Nadal-Barón P, Saubi N, Mendoza-Palomar N, Bernat-Sole M, Albasanz-Puig A, Piñana M, Andrés C, Melendo-Pérez S, Larrosa N, Antón A, Esperalba J.   +16 more
europepmc   +2 more sources

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

OncoImmunology, 2022
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell   +10 more
doaj   +1 more source

Early immune surveillance to predict cytomegalovirus outcomes after allogeneic hematopoietic stem cell transplantation

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundThere is no method of predicting human cytomegalovirus (HCMV) outcomes in allogeneic hematopoietic stem cell transplant recipients clinically, leading in some cases to excessive or insufficient antiviral therapy.
Jintao Xia, Xuejie Li, Genyong Gui, Jian Wu, Shengnan Gong, Yuxin Shang, Jun Fan   +6 more
doaj   +1 more source

Human Cytomegalovirus Infection Induces High Expression of Prolactin and Prolactin Receptors in Ovarian Cancer

Biology, 2020
One of the potential biomarkers for ovarian cancer patients is high serum level of prolactin (PRL), which is a growth factor that may promote tumor cell growth.
Afsar Rahbar, Amira AlKharusi, Helena Costa, Mattia Russel Pantalone, Ourania N. Kostopoulou, Huanhuan L. Cui, Joseph Carlsson, Angelique Flöter Rådestad, Cecilia Söderberg-Naucler, Gunnar Norstedt   +9 more
doaj   +1 more source

Positive HCMV DNAemia in stem cell recipients undergoing letermovir prophylaxis is expression of abortive infection

American Journal of Transplantation, 2020
Letermovir (LMV) inhibits HCMV replication by binding to components of the HCMV‐terminase complex showing a potential role in prevention of HCMV‐related complications in allogenic hematopoietic stem cell transplant recipients (allo‐HSCTRs).
I. Cassaniti, A. Colombo, P. Bernasconi, M. Malagola, D. Russo, Anna Paola Iori, C. Girmenia, R. Greco, J. Peccatori, F. Ciceri, F. Bonifazi, E. Percivalle, G. Campanini, G. Piccirilli, T. Lazzarotto, F. Baldanti   +15 more
semanticscholar   +1 more source

Regulation of the MIE Locus During HCMV Latency and Reactivation

Pathogens, 2020
Human cytomegalovirus (HCMV) is a ubiquitous herpesviral pathogen that results in life-long infection. HCMV maintains a latent or quiescent infection in hematopoietic cells, which is broadly defined by transcriptional silencing and the absence of de novo
Abigail L Dooley, C. O’Connor
semanticscholar   +1 more source

Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome [PDF]

Journal of Virology, 2004
ABSTRACT Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex enveloped virus composed of both viral and cellular gene products. While the sequence of the HCMV genome has been known for over a decade, the full set of viral and cellular proteins that compose the HCMV virion are unknown.
Thomas Shenk, Daniel N. Streblow, David G. Camp, Dai Wang, Steven Wiley, Patricia P. Smith, William J. Britt, Ljiljana Paša-Tolić, Susan M. Varnum, Matthew E. Monroe, Kenneth J. Auberry, Karin D. Rodland, Jay A. Nelson, Richard D. Smith   +13 more
openaire   +5 more sources