Results 31 to 40 of about 28,017 (205)

A Review of the Potential Role of Human Cytomegalovirus (HCMV) Infections in Breast Cancer Carcinogenesis and Abnormal Immunity

Cancers, 2019
Previously recognized classical human onco-viruses can regulate complex neoplastic events, and are estimated to play a role during carcinogenesis in 15–20% of cancer cases.
J. Geisler, J. Touma, A. Rahbar, C. Söderberg-Nauclér, K. Vetvik   +4 more
semanticscholar   +1 more source

A Viral Pilot for HCMV Navigation? [PDF]

Viruses, 2015
gH/gL virion envelope glycoprotein complexes of herpesviruses serve as entry complexes and mediate viral cell tropism. By binding additional viral proteins, gH/gL forms multimeric complexes which bind to specific host cell receptors. Both Epstein–Barr virus (EBV) and human cytomegalovirus (HCMV) express alternative multimeric gH/gL complexes.
openaire   +3 more sources

HCMV GrAbs a Mechanism to Escape Neutralization [PDF]

Cell Host & Microbe, 2011
The HCMV-neutralizing monoclonal antibody MSL-109 failed to prevent HCMV-induced disease in the clinic. In this issue of Cell Host & Microbe, Manley et al. (2011) found that MSL-109 rapidly induces antibody resistance by a nongenetic mechanism. Their results shed light on how antibodies can interact with their targets both outside and inside infected ...
Tina M. Cairns, Roselyn J. Eisenberg, Gary H. Cohen   +2 more
openaire   +3 more sources

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells [PDF]

, 2014
Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence. Without immune pressure, laboratory-adapted HCMV strains have undergone genetic alterations.
Aicheler, Andrew J. Davison, Arnon, Benedict, Bentz, Billadeau, Borivoj Vojtesek, Brown, Butler, Cerboni, Chapman, Dargan, Davis, Eddie C.Y. Wang, Evans, Fielding, Gavin S. Wilkie, Gavin W.G. Wilkinson, Gross, Humphries, Jürgen Haas, Kelly L. Miners, Kim, Le, Mace, Marco A. Purbhoo, Marcus Heinzmann, Melanie Moore, Michael P. Weekes, Morris, Orange, Paul J. Lehner, Penfold, Peter Tomasec, Prod’homme, Prod’homme, Prod’homme, Rak, Rebecca J. Aicheler, Richard J. Stanton, Riedl, Robin Antrobus, Ryu, Seo, Smith, Stanton, Stanton, Stanton, Stephen Man, Striebinger, Susanne M. Bailer, Takenawa, Tani, Taylor, Tomasec, Tomasec, Umashankar, Virginie Prod’homme, Wang, Weekes, Wilkinson   +60 more
core   +3 more sources

Multiple infections by EBV, HCMV and Helicobacter pylori are highly frequent in patients with chronic gastritis and gastric cancer from Southwest Mexico

Medicine, 2019
The chronic inflammation and damage to the gastric epithelium induced by Helicobacter pylori (H. pylori) are the main risk factors for gastric cancer development.
Oscar del Moral-Hernández, Carlos A Castañón-Sánchez, S. Reyes-Navarrete, D. Martínez-Carrillo, R. Betancourt-Linares, H. Jiménez-Wences, Sol de la Peña, A. Román-Román, Daniel Hernández-Sotelo, G. Fernández-Tilapa   +9 more
semanticscholar   +1 more source

Human Cytomegalovirus (HCMV)-infected Astrocytoma Cells Impair the Function of HCMV-specific Cytotoxic T Cells [PDF]

Journal of Korean Medical Science, 2020
Human cytomegalovirus (HCMV) infection in glioblastoma multiforme (GBM) is associated with a poor prognosis and may affect the pathogenesis of GBM. In this study, we investigated the role of HCMV-infected astrocytoma cells in impairing the activity of cytotoxic T lymphocytes (CTLs) specific to the HCMV protein.CTLs specific to HCMV immediate early (IE)-
Won Woo Lee, Won Woo Lee, Eung Soo Hwang, Eung Soo Hwang, Ji Yeon Kim, Ji Yeon Kim   +5 more
openaire   +3 more sources

Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente [PDF]

, 2001
Tumor necrosis factor (TNF)-related cytokines regulate cell death and survival and provide strong selective pressures for viruses, such as cytomegalovirus (CMV), to evolve counterstrategies in order to persist in immune-competent hosts.
Angulo, A, Banks, T A, Benedict, C A, Britt, W J, Ghazal, P, Ko, M, Senderowicz, L, Ware, C F   +7 more
core   +1 more source

HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways

Nature Communications, 2019
The mechanisms by which many human cytomegalovirus (HCMV)-encoded proteins help the virus to evade immune surveillance remain poorly understood. In particular, it is unknown whether HCMV proteins arrest Toll-like receptor (TLR) signaling pathways ...
Areum Park, E. Ra, Taeyun A. Lee, H. Choi, Eunhye Lee, Sujin Kang, J. Seo, Sungwook Lee, Boyoun Park   +8 more
semanticscholar   +1 more source

HCMV Assembly Is Totally Tubular [PDF]

Developmental Cell, 2018
Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules and regulates infectious virion ...
Robert F. Kalejta, Shelby M. Lyon
openaire   +3 more sources

HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation

bioRxiv, 2019
Reactivation of latent Human Cytomegalovirus (HCMV) in CD34+ hematopoietic progenitor cells (HPCs) is closely linked to hematopoiesis. Viral latency requires maintenance of the progenitor cell quiescence, while reactivation initiates following ...
I. Mikell, Lindsey B. Crawford, Meaghan H. Hancock, Jennifer Mitchell, J. Buehler, F. Goodrum, J. Nelson   +6 more
semanticscholar   +1 more source