Results 31 to 40 of about 46,134 (291)
Insight for Immunotherapy of HCMV Infection [PDF]
International Journal of Biological Sciences, 2021 Human cytomegalovirus (HCMV), a ubiquitous in humans, has a high prevalence rate. Young people are susceptible to HCMV infection in developing countries, while older individuals are more susceptible in developed countries. Most patients have no obvious symptoms from the primary infection.
Long, Xinmiao +3 more
openaire +2 more sources
American Journal of Transplantation, 2020 Letermovir (LMV) inhibits HCMV replication by binding to components of the HCMV‐terminase complex showing a potential role in prevention of HCMV‐related complications in allogenic hematopoietic stem cell transplant recipients (allo‐HSCTRs).
I. Cassaniti +15 more
semanticscholar +1 more source
Regulation of the MIE Locus During HCMV Latency and Reactivation
Pathogens, 2020 Human cytomegalovirus (HCMV) is a ubiquitous herpesviral pathogen that results in life-long infection. HCMV maintains a latent or quiescent infection in hematopoietic cells, which is broadly defined by transcriptional silencing and the absence of de novo
Abigail L Dooley, C. O’Connor
semanticscholar +1 more source
NK cells expansion in vitro is followed by loss of inhibitory KIR expression
Медицинская иммунология, 2023 NK cells are innate lymphocytes that are able to eliminate altered cells, which makes them promising for the immunotherapy of viral diseases and tumors. The NK cell population is characterized by high phenotypic and functional diversity.
N. A. Alekseeva +5 more
doaj +1 more source
Tuning the Orchestra: HCMV vs. Innate Immunity
Frontiers in Microbiology, 2020 Understanding how the innate immune system keeps human cytomegalovirus (HCMV) in check has recently become a critical issue in light of the global clinical burden of HCMV infection in newborns and immunodeficient patients. Innate immunity constitutes the
Valentina Dell’Oste +8 more
semanticscholar +1 more source
The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]
, 1985 The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael +9 more
core +1 more source
Infection of human cytomegalovirus in cultured human gingival tissue. [PDF]
, 2006 BackgroundHuman cytomegalovirus (HCMV) infection in the oral cavity plays an important role in its horizontal transmission and in causing viral-associated oral diseases such as gingivitis.
Chu, Alice +5 more
core +3 more sources
Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation. [PDF]
, 2020 Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients, and treatment options are limited by toxicities. CSJ148 is a combination of two anti-HCMV human monoclonal antibodies (LJP538 and LJP539) that bind to and inhibit ...
Akard, Luke +22 more
core +3 more sources
Journal of Pure and Applied Microbiology, 2019 Oral carcinogenesis is a multi-step process, affecting predominantly elderly males with a long history of smoking and alcohol drinking while the role of infectious agents in its progression has not been fully identified.
Hayat Ghaith Sachit +4 more
doaj +1 more source
Decidual CD4 Effector Memory and Resident Memory T Cells Respond to Cord Blood Allo‐Antigens [PDF]
Am J Reprod ImmunolABSTRACT Problem Maternal CD4 T cells are critical coordinators of maternal–fetal immune tolerance and immunity during pregnancy. Decidual regulatory T cells (TREG) have been shown to provide essential immune suppressive functions to control allogeneic responses and inflammation.
Koenig Z +7 more
europepmc +2 more sources