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HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV‐Associated Pathogenesis [PDF]
Oxidative Medicine and Cellular Longevity, 2016 HCV (hepatitis C virus) is a member of the Flaviviridae family that contains a single‐stranded positive‐sense RNA genome of approximately 9600 bases. HCV is a major causative agent for chronic liver diseases such as steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma which are caused by multifactorial processes.
Regina Medvedev +2 more
openaire +2 more sources
Boceprevir for Untreated Chronic HCV Genotype 1 Infection
New England Journal of Medicine, 2011 Background Peginterferon–ribavirin therapy is the current standard of care for chronic infection with hepatitis C virus (HCV). The rate of sustained virologic response has been below 50% in cases of HCV genotype 1 infection. Boceprevir, a potent oral HCV-
Sprint Investigators
semanticscholar +2 more sources
Virulence, 2021 Involvement of extracellular nicotinamide phosphoribosyltransferase (eNAMPT, i.e., visfatin or pre-B-cell colony-enhancing factor), a cancer metabokine, in chronically hepatitis C virus (HCV)-infected (CHC) patients with sustained virological responses ...
Ming-Ling Chang +5 more
doaj +1 more source
Substance Abuse Treatment, Prevention, and Policy, 2019 Background The National Institute on Drug Abuse has identified a persistent research-to-practice gap in the implementation of evidence-based prevention and treatment programs for substance use disorder. To identify mechanisms to close this gap, we sought
Zachary F. Meisel +9 more
doaj +1 more source
Virulence, 2021 Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity.
Jian Shang +10 more
doaj +1 more source
Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection.
New England Journal of Medicine, 2015 BACKGROUND A simple treatment regimen that is effective in a broad range of patients who are chronically infected with the hepatitis C virus (HCV) remains an unmet medical need.
J. Feld +23 more
semanticscholar +1 more source
Comparison of HCV core antigen and anti-HCV with HCV RNA results
African Health Sciences, 2015 The measurement of anti-HCV antibodies using immunological methods and the confirmation of viral nuclear acid based on molecular methods is important in diagnosis and follow-up of the HCV infection.In this study, we aimed to analyse HCV core Antigen positivity among anti-HCV antibody positive sera to determine the significance of testing of HCV core Ag
Ayse, Aynali +4 more
openaire +7 more sources
Treatment of HCV infection by targeting microRNA.
New England Journal of Medicine, 2013 BACKGROUND The stability and propagation of hepatitis C virus (HCV) is dependent on a functional interaction between the HCV genome and liver-expressed microRNA-122 (miR-122).
H. Janssen +14 more
semanticscholar +1 more source
Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV† [PDF]
Hepatology, 2004 Persons with human immunodeficiency virus (HIV) and hepatits C virus (HCV) coinfection are at increased risk for progression to cirrhosis compared with persons with HCV alone, but the reasons for this are unclear. In chronic HCV, the mechanism of liver injury is presumed to be due to HCV-specific T cell destruction of ...
Nezam H. Afdhal +9 more
openaire +3 more sources
Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.
New England Journal of Medicine, 2014 BACKGROUND In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with ...
N. Afdhal +23 more
semanticscholar +1 more source