Results 141 to 150 of about 21,262 (243)

A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin [PDF]

, 2016
Ruthenium complexes are considered as potential replacements for platinum compounds in oncotherapy. Their clinical development is handicapped by a lack of consensus on their mode of action.
Balch, Barton, Barton, Brabec, Carlisle, Davey, Dyson, Dyson, Dyson, Dyson, Dyson, Gaiddon, Gaiddon, Gaiddon, Harlepp, Herlyn, Hooker, Jodrell, Kehat, Kelland, Keppler, Keppler, Komarova, Lippard, Loeffler, Loeffler, Loeffler, Loeffler, Markman, Meeran, Messori, Mestroni, Pfeffer, Pfeffer, Pfeffer, Sadler, Sadler, Sadler, Sava, Sava, Schellens, Seifried, Span, Tallarida, Zassinovich, Zeller   +45 more
core   +4 more sources

Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p [Retraction]

Cancer Management and Research, 2023
Liu J, Feng G, Li Z, Li R, Xia P. Cancer Manag Res. 2020;12:10199–10210. We, the Editors and Publisher of Cancer Management and Research, have retracted the following article. Since publication, concerns have been raised about the integrity of the
Liu J, Feng G, Li Z, Li R, Xia P
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HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs

Molecules and Cells, 2015
Fiber type-specific programs controlled by the transcription factor MEF2 dictate muscle functionality. Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers.
Cohen, Todd J., Choi, Moon-Chang, Kapur, Meghan, Lira, Vitor A., Yan, Zhen, Yao, Tso-Pang   +5 more
openaire   +3 more sources

Mesenchymal Stem Cell–Originated Exosomal Circular RNA circFBXW7 Attenuates Cell Proliferation, Migration and Inflammation of Fibroblast-Like Synoviocytes by Targeting miR-216a-3p/HDAC4 in Rheumatoid Arthritis

Journal of Inflammation Research, 2021
Lihua Chang,1 Liang Kan2 1Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China; 2Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical ...
Chang L, Kan L
doaj  

Roles of Histone Deacetylase 4 in the Inflammatory and Metabolic Processes [PDF]

Diabetes & Metabolism Journal
Histone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins ...
Hyunju Kang, Young-Ki Park, Ji-Young Lee, Minkyung Bae   +3 more
doaj   +1 more source

The Actin-binding Protein Moesin and Memory Formation in Drosophila : A thesis presented to Massey University in partial fulfillment of the requirements for the degree of Master of Science in Biochemistry [PDF]

, 2016
Moesin is a cytoskeletal adaptor protein that plays an important role in modification of the actin cytoskeleton and the formation of dendritic spines, which may be crucial to long-term potentiation.
Freymuth, Patrick Stephen
core  

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Effects of novel HDAC inhibitors on urothelial carcinoma cells

Clinical Epigenetics, 2018
Background Histone deacetylase inhibitors (HDACi) are promising anti-cancer drugs that could also be employed for urothelial carcinoma (UC) therapy. It is unclear, however, whether inhibition of all 11 zinc-dependent HDACs or of individual enzymes is ...
Aline Kaletsch, Maria Pinkerneil, Michèle J. Hoffmann, Ananda A. Jaguva Vasudevan, Chenyin Wang, Finn K. Hansen, Constanze Wiek, Helmut Hanenberg, Christoph Gertzen, Holger Gohlke, Matthias U. Kassack, Thomas Kurz, Wolfgang A. Schulz, Günter Niegisch   +13 more
doaj   +1 more source

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]

, 2017
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco, Bordin, Antonella, Carrizzo, Albino, Chimenti, Isotta, DE FALCO, Elena, Forte, Maurizio, Frati, Giacomo, Nocella, Cristina, Pagano, Francesca, Palmerio, Silvia, Schiavon, Sonia, Schirone, Leonardo, Sciarretta, Sebastiano, Valenti, Valentina, Vecchione, Carmine, Yee, Derek   +15 more
core   +3 more sources

The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy

Journal of Inflammation Research, 2022
Zhengquan Dong,1 Zhou Ma,1 Meiju Yang,2 Linlin Cong,2 Ruipeng Zhao,1 Liyun Cheng,3 Jian Sun,1 Yunfei Wang,1 Ruijia Yang,2 Xiaochun Wei,1 Pengcui Li1 1Department of Orthopaedic, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, The Second ...
Dong Z, Ma Z, Yang M, Cong L, Zhao R, Cheng L, Sun J, Wang Y, Yang R, Wei X, Li P   +10 more
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