Results 151 to 160 of about 21,262 (243)

Aberrant expression of histone deacetylases 4 in cognitive disorders: molecular mechanisms and a potential target

Frontiers in Molecular Neuroscience, 2016
Histone acetylation is a major mechanism of chromatin remodeling, contributing to epigenetic regulation of gene transcription. Histone deacetylases (HDACs) are involved in both physiological and pathological conditions by regulating the status of histone
Yili Wu, fei hou, xin wang, qingsheng kong, xiaolin han, bo bai   +5 more
doaj   +1 more source

Curcumin attenuates pressure overload-induced cardiac fibrosis in mice via modulating the miR-29b/HDAC4 axis

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the antifibrotic effects of curcumin in a transverse aortic constriction (TAC) mouse model and elucidate its molecular mechanisms. Methods: Male C57BL/6 mice underwent TAC and received vehicle, low-dose curcumin (50 mg/kg), high-
Yu Xiang, Ying Lv, Xiao-Xiang Liu, Bo-Tao Li, Jing Liu   +4 more
doaj   +1 more source

Effect of moderate intensity exercise on HDAC4 and CaMKII genes expression in myocardium of male rats

Fiyz̤, 2020
Background: Histone Dacetylases-4 (HDAC4) is phosphorylated by calcium-calmodulin-dependent kinase (CaMKII) that plays an important role in cardiac tissue hypertrophy.
Mojdeh Khajehlandi, Lotfali Bolboli , Marefat Siahkuhian, Mohammad Rami, Mohammadreza Tabandeh   +4 more
doaj  

Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53‐dependent senescence and favors cell transformation

Molecular Oncology, 2018
Expression of the class IIa HDACs is frequently altered in different human cancers. In mouse models these transcriptional repressors can trigger transformation, acting as bona fide oncogenes.
Harikrishnareddy Paluvai, Eros Di Giorgio, Claudio Brancolini   +2 more
doaj   +1 more source

Regulation of SUMO Modification [PDF]

, 2007
The small ubiquitin related modifier SUMO is a posttranslational modifier that functions in a wide range of cellular processes like intracellular transport, cell cycle regulation, DNA repair and regulation of transcription.
Knipscheer, P.M. (Puck Maria)
core   +1 more source

LINC00847 drives pancreatic cancer progression by targeting the miR-455-3p/HDAC4 axis

Archives of Medical Science
Introduction Pancreatic cancer (PC) is a common malignant tumor of the digestive system, posing a serious threat to the life of patients. This study aims to investigate the role of LINC00847 and the LINC00847/miR-455-3p/HDAC4 mechanism in PC progression.
Shunxin Hao, Zhi Yao, Yifeng Liu
doaj   +1 more source

A novel aptamer-based enzymatic assay for the diagnosis of Malaria [PDF]

, 2014
Poster Presentation - Theme 2: Cancer & other diseasesMalaria causes nearly 1 million annual fatalities in lesser developed regions in South East Asia and Africa.
Dirkzwager, R, Tanner, JA
core  

HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.

Cancer Letters, 2023
Xueshuo Sun, Kun Zhang, Xingzhi Peng, Peijun Zhou, Chunhui Qu, Lifang Yang, Liang Shen   +6 more
semanticscholar   +1 more source

Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons.

Ecotoxicology and Environmental Safety, 2023
Yongjie Xu, Sijia Wei, Liying Zhu, Chang-Lun Huang, Tingting Yang, Shuang Wang, Yiqiong Zhang, Yunfeng Duan, Xing Li, Zhengrong Wang, Wei Pan   +10 more
semanticscholar   +1 more source

Abstracts of the 18th SCWD Conference, 11‐13 December 2025 in Rome/Italy

JCSM Communications, Volume 9, Issue 1, January/June 2026.
wiley   +1 more source