Results 171 to 180 of about 14,188 (207)

RPA hyperphosphorylation hinders the resolution of R-loops and G-quadruplex-associated R-loops during RAS-driven senescence. [PDF]

Nucleic Acids Res
Cortolezzis Y, Tolotto V, Triboli L, Picco R, Soler MA, Fortuna S, Bettin G, D'Este F, Carlassara E, Magris G, Miller KM, Angelini A, Xodo LE, Di Giorgio E.   +13 more
europepmc   +1 more source

Editorial expression of concern: Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK. [PDF]

Reprod Biol Endocrinol
Yao L, Wan J, Li H, Ding J, Wang Y, Wang X, Li M.   +6 more
europepmc   +1 more source

Computational modeling of ATM signaling: a predictive framework for drug repurposing in ataxia-telangiectasia. [PDF]

NPJ Syst Biol Appl
Merulla AE, Di Salvatore V, Gullotta GS, Maleki A, Russo G, Caraci F, Copani A, Pappalardo F.   +7 more
europepmc   +1 more source

Selective HDAC4 inhibition by SP1-PTD promotes odontoblast differentiation. [PDF]

J Appl Oral Sci
Shin YK, Moon JS, Son SK, Lee BN, Park C, Kim SH, Lee YC, Kim MS.   +7 more
europepmc   +1 more source

The growth factor FGF21 maintains neuromuscular junction through histone deacetylase HDAC4 in denervation-induced skeletal muscle atrophy. [PDF]

J Biol Chem
Zheng L, Sasaki T, Ni L, Hashidume T, Kawabe M, Takahashi Y, Yamauchi Y, Shimizu M, Sato R.   +8 more
europepmc   +1 more source

The Combined Expression Profiles of Epigenetic Biomarkers Reveal Heterogeneity in Normospermic Human Sperm Samples. [PDF]

Genes (Basel)
Cassuto NG, Boitrelle F, Ruoso L, Bouattane O, Bendayan M, Abdiche L, Larue L, Keromnes G, Lédée N, Prat-Ellenberg L, Dray G, Rouen A, De Vos J, Assou S.   +13 more
europepmc   +1 more source

CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes [PDF]

Basic Research in Cardiology, 2021
Nuclear histone deacetylase 4 (HDAC4) represses MEF2-mediated transcription, implicated in the development of heart failure. CaMKII-dependent phosphorylation drives nucleus-to-cytoplasm HDAC4 shuttling, but protein kinase A (PKA) is also linked to HDAC4 ...
Jeffrey R Erickson, Senka Ljubojevic-Holzer, Julie Bossuyt   +2 more
exaly   +2 more sources

HDAC4: Mechanism of Regulation and Biological Functions [PDF]

Epigenomics, 2014
The acetylation and deacetylation of histones plays an important role in the regulation of gene transcriptions. Histone acetylation is mediated by histone acetyltransferase; the resulting modification in the structure of chromatin leads to nucleosomal relaxation and altered transcriptional activation.
Gangjian Qin, Ting C Zhao, Zhengke Wang
exaly   +3 more sources