Results 181 to 190 of about 14,188 (207)

ABHD5 cleaves HDAC4 to benefit the heart

Nature Metabolism, 2019
A study in Nature Metabolism reveals a hitherto-unknown enzymatic and physiological role of ABHD5, which acts as a protease that couples extracellular cues to the epigenome of cardiomyocytes by cleaving histone deacetylase 4 (HDAC4).
Joshua G. Travers, Timothy A. McKinsey
openaire   +2 more sources

Synthesis and Characterization of Reversible Covalent HDAC4 Inhibitors

2022
Cyanoacrylates define a class of inhibitors which are capable to form a transient covalent bond with a cysteine flanking the binding site, thereby increasing the residence time and prolonging the inhibitory effect on the target protein under nonequilibrium conditions.
Anton, Frühauf, Benjamin, Wolff, Markus, Schweipert, Franz-Josef, Meyer-Almes   +3 more
openaire   +2 more sources

HDAC4 stabilizes SIRT1 via sumoylation SIRT1 to delay cellular senescence

Clinical and Experimental Pharmacology and Physiology, 2016
The nicotinamide adenine dinucleotide-dependent protein deacetylase silent information regulator 2 (Sir2) regulates cellular lifespan in several organisms.
Jing Niu, Tong Tanjun
exaly   +2 more sources

HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway

Cancers, 2019
International audienceGastric cancer (GC) remains a health issue due to the low efficiency of therapies, such as cisplatin. This unsatisfactory situation highlights the necessity of finding factors impacting GC sensibility to therapies.
Alain C Jung, Sébastien Pfeffer, Alexandre Gries   +2 more
exaly   +2 more sources

Regional and subcellular distribution of HDAC4 in mouse brain

Journal of Comparative Neurology, 2009
AbstractHistone deacetylases (HDACs) are part of a system that links epigenetic control of gene expression to a variety of environmental stimuli. Some HDACs, including HDAC4, shuttle between the cytoplasm and nucleus in response to physiological cues such as calcium signaling.
Michael J, Darcy, Kate, Calvin, Katie, Cavnar, Charles C, Ouimet   +3 more
openaire   +2 more sources

HDAC4 Mediates Smoking-Induced Pancreatic Cancer Metastasis

Pancreas, 2022
Objective Cigarette smoking is an established risk factor for pancreatic ductal adenocarcinoma (PDAC). In this project, we investigated the effect of smoking and the role of histone deacetylase 4 (HDAC4) in PDAC invasion and metastasis.
Jiyong, Yang, Chintan, Chheda, Adrian, Lim, Dina, Hauptschein, Latifa, Zayou, Josiah, Tang, Stephen J, Pandol, Mouad, Edderkaoui   +7 more
openaire   +2 more sources

HDAC4 regulates vascular inflammation via activation of autophagy [PDF]

Cardiovascular Research, 2018
Angiotensin II (Ang II) causes vascular inflammation, leading to vascular endothelial cell dysfunction, and is associated with the development of cardiovascular diseases. Therefore, interventions in inflammation may contribute to the reduction of cardiovascular diseases.
Yi Zhun Zhu, Xinhua Liu, Weijun Wu
exaly   +3 more sources

HDAC4‐AS1/CTCF Transcriptionally Represses HDAC4 Under Stress, Whereas HDAC4 Inhibits Stress‐Induced Syncytiotrophoblast Cellular Pyroptosis by Deacetylating NLRP3 and GSDMD

Cell Biochemistry and Function
ABSTRACTOur previous study reported that histone deacetylase 4 (HDAC4) expression is significantly downregulated in placental tissues of pre‐eclampsia (PE) pregnancies. Cellular pyroptosis is a key event in the pathogenesis of PE that induces the release of factors into the maternal circulation.
Juan Du, Qinghong Ji, Lihua Dong, Lanlan Wang, Gang Xin   +4 more
openaire   +2 more sources

HDAC4-mediated Deacetylation of Glutaminase Facilitates Glioma Stemness

Current Cancer Drug Targets, 2023
Background: Inhibiting cancer metabolism via glutaminase (GLS) is a promising strategy to disrupt tumor progression. However, the mechanism regarding GLS acetylation remains largely unknown. Methods: Mitochondrial protein isolation and glutaminase activity assay were used to examine GLS activity.
Gang, Xu, Jianqiang, Qu, Ming, Zhang
openaire   +2 more sources

Expression characterization and the promoter activity analysis of zebrafish hdac4

Fish Physiology and Biochemistry, 2011
Histone deacetylase 4 (HDAC4) is an important modifier enzyme for chromatin remodeling and plays an essential role in regulating gene expression. Spatio-temporal expression spectrum revealed that zebrafish hdac4 mRNA, ubiquitously distributed in various tissues, were significantly higher at 36 hpf (hours post-fertilization) and 6 dpf (days post ...
Kecheng, Zhu, Huanling, Wang, Yasmeen, Gul, Yuhua, Zhao, Weimin, Wang, Shasha, Liu, Min, Wang   +6 more
openaire   +2 more sources