Results 181 to 190 of about 3,384,133 (256)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl-x_L or Mcl-1 in ovarian cancer. [PDF]

Mol Oncol
Thomine C, Guillemot S, Weiswald LB, Florent R, Abeilard E, Giffard F, Brotin E, Briand M, Dolivet E, Poulain L, Villedieu M.   +10 more
europepmc   +1 more source

CD47 blockade reverses resistance to HDAC inhibitor by liberating anti-tumor capacity of macrophages. [PDF]

J Exp Clin Cancer Res
Xu X, Wang Q, Guo K, Xu J, Lu Y, Chen H, Hu W, Fu Y, Sun L, He Y, Chen Z, Xia W, Pan M, Lin B, Yang W, Wang Q, Wen Z, Cao Q, Xiao P.   +18 more
europepmc   +1 more source

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, Volume 46, Issue 4, Page 989-1004, July 2026.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large cell lymphoma: implications for HDAC inhibitor therapy. [PDF]

Leukemia
Zrimšek M, Draganić K, Malzer A, Doblmayr V, Mišura K, de Freitas E Silva R, Matthews JD, Iannelli F, Wohlhaupter S, Pérez Malla CU, Fischer H, Schachner H, Schiefer AI, Sheibani-Tezerji R, Chiarle R, Turner SD, Ellmeier W, Seiser C, Egger G.   +18 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Enhancing doxorubicin's anticancer impact in colorectal cancer by targeting the Akt/Gsk3β/mTOR-SREBP1 signaling axis with an HDAC inhibitor. [PDF]

Korean J Physiol Pharmacol
Zhao H, Wu Y, Kim SM.
europepmc   +1 more source

Diaphragm‐specific effects of L‐citrulline in mdx mice highlight its potential as adjuvant of standard therapy in Duchenne muscular dystrophy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3866-3884, July 2026.
Abstract Background and Purpose The absence of the protein dystrophin in Duchenne muscular dystrophy (DMD) leads to progressive muscle weakness, failing regeneration and deregulation of nitric oxide (NO) signalling. We focused on L‐citrulline, a precursor of L‐arginine, required for NO production in muscle, which is reduced in dystrophic mdx muscle ...
Lisamaura Tulimiero, Brigida Boccanegra, Paola Mantuano, Antonietta Mele, Michela De Bellis, Roberta Lenti, Francesca Sanarica, Santa Cirmi, Elena Conte, Ornella Cappellari, Amber E. Sherrard, Ardawna Green, Mira Srinivasa, Marta L. Fiorotto, Annamaria De Luca   +14 more
wiley   +1 more source

The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin. [PDF]

Sci Rep
Huang YH, Huang YM, Huang WJ, Yu MC, Chuang CH, Hsu YF, Chen HC, Chen LC, Huang SW, Hsu MJ.   +9 more
europepmc   +1 more source

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

European Journal of Haematology, Volume 117, Issue 1, Page 24-41, July 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Marco Fiorillo, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies. [PDF]

Int J Mol Sci
Buccheri R, Coco A, Pasquinucci L, Amata E, Marrazzo A, Rescifina A.   +5 more
europepmc   +1 more source